Efficient degradation of ivermectin by newly isolated Aeromonas taiwanensis ZJB-18,044 View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2020-09-16

AUTHORS

Yuanshan Wang, Meihua Gong, Xianlin Wang, Xiaolun Peng, Yuwei Wang, Jiahui Guan, Dongyuan Cheng, Chunyue Weng, Yuguo Zheng

ABSTRACT

Ivermectin (IVM) is a widely used antiparasitic agent and acaricide. Despite its high efficiency against nematodes and arthropods, IVM may pose a threat to the environment due to its ecotoxcity. In this study, degradation of IVM by a newly isolated bacterium Aeromonas taiwanensis ZJB-18,044 was investigated. Strain ZJB-18,044 can completely degrade 50 mg/L IVM in 5 d with a biodegradation ability of 0.42 mg/L/h. Meanwhile, it exhibited high tolerance (50 mg/L) to doramectin, emamectin, rifampicin, and spiramycin. It can also efficiently degrade doramectin, emamectin, and spiramycin. The IVM degradation of strain ZJB-18,044 can be inhibited by erythromycin, azithromycin, spiramycin or rifampicin. However, supplement of carbonyl cyanide m-chlorophenylhydrazone, an uncoupler of oxidative phosphorylation, can partially recover the IVM degradation. Moreover, strain ZJB-18,044 cells can pump out excess IVM to maintain a low intracellular IVM concentration. Therefore, the IVM tolerance of strain ZJB-18,044 may be due to the regulation of the intracellular IVM concentration by the activated macrolide efflux pump(s). With the high IVM degradation efficiency, A. taiwanensis ZJB-18,044 may serve as a bioremediation agent for IVM and other macrolides in the environment. More... »

PAGES

1-14

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s10532-020-09909-8

DOI

http://dx.doi.org/10.1007/s10532-020-09909-8

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1130862314

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/32936376


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29 IVM degradation efficiency
30 IVM tolerance
31 ZJB
32 ability
33 acaricides
34 agents
35 antiparasitic agents
36 arthropods
37 azithromycin
38 bacterium Aeromonas taiwanensis ZJB
39 biodegradation ability
40 bioremediation agents
41 carbonyl cyanide
42 cells
43 chlorophenylhydrazone
44 concentration
45 cyanide
46 degradation
47 degradation efficiency
48 degradation of ivermectin
49 doramectin
50 ecotoxcity
51 efficiency
52 efficient degradation
53 efflux
54 emamectin
55 environment
56 erythromycin
57 excess IVM
58 high IVM degradation efficiency
59 high efficiency
60 high tolerance
61 intracellular IVM concentration
62 ivermectin
63 low intracellular IVM concentration
64 macrolide efflux
65 nematodes
66 oxidative phosphorylation
67 phosphorylation
68 regulation
69 rifampicin
70 spiramycin
71 strain ZJB
72 study
73 supplements
74 taiwanensis ZJB
75 threat
76 tolerance
77 uncoupler
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