Biological synthesis of nicotinamide mononucleotide View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2021-10-09

AUTHORS

Qi Shen, Shi-Jia Zhang, Yu-Zhen Xue, Feng Peng, Dong-Yuan Cheng, Ya-Ping Xue, Yu-Guo Zheng

ABSTRACT

Nicotinamide mononucleotide (NMN) or Nicotinamide-1-ium-1-β-D-ribofuranoside 5′-phosphate is a nucleotide that can be converted into nicotinamide adenine dinucleotide (NAD) in human cells. NMN has recently attracted great attention because of its potential as an anti-aging drug, leading to great efforts for its effective manufacture. The chemical synthesis of NMN is a challenging task since it is an isomeric compound with a complicated structure. The majority of biological synthetic routes for NMN is through the intermediate phosphoribosyl diphosphate (PRPP), which is further converted to NMN by nicotinamide phosphoribosyltransferase (Nampt). There are various routes for the synthesis of PRPP from simple starting materials such as ribose, adenosine, and xylose, but all of these require the expensive phosphate donor adenosine triphosphate (ATP). Thus, an ATP regeneration system can be included, leading to diminished ATP consumption during the catalytic process. The regulations of enzymes that are not directly involved in the synthesis of NMN are also critical for the production of NMN. The aim of this review is to present an overview of the biological production of NMN with respect to the critical enzymes, reaction conditions, and productivity. More... »

PAGES

2199-2208

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s10529-021-03191-1

DOI

http://dx.doi.org/10.1007/s10529-021-03191-1

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1141748943

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/34626279


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