TERT enhances the survival rate of human fibroblasts under endoplasmic reticulum, Golgi apparatus, and lysosomal stresses View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2018-06

AUTHORS

Amer Ali Abd El-Hafeez, Toru Hosoi, Kanako Nakatsu, Mina Thon, Akira Shimamoto, Hidetoshi Tahara, Koichiro Ozawa

ABSTRACT

OBJECTIVE: The exposure of organelles, such as the endoplasmic reticulum (ER), Golgi apparatus (GA), and lysosomes, to stress activates death mechanisms. Recently, telomerase reverse transcriptase (TERT) has been shown to be involved in cell survival. However, the relationship between TERT and the stress responses is still unclear. Here, we aimed to clarify the possible mechanisms of action through which TERT promotes cell survival by studying its effect on the stresses faced by multiple organelles in human fibroblasts. RESULTS: We found that TERT enhanced the survival rate of cells under ER stress, regardless of ER stress inducers such as tunicamycin (protein glycosylation inhibitor), thapsigargin (Ca2+-ATPase inhibitor), brefeldin A (protein transport inhibitor), or dithiothreitol (disulfide bond formation inhibitor). We also found that TERT enhanced the survival rate of cells under GA and lysosomal stresses. CONCLUSION: Collectively, these results suggest that TERT suppresses cell stress and promotes cell survival via different mechanisms. These findings may offer new insights into the implications of TERT in the treatment of stress-induced conditions such as aging, obesity, and neurodegenerative diseases. More... »

PAGES

915-922

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s10529-018-2544-1

DOI

http://dx.doi.org/10.1007/s10529-018-2544-1

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1103172478

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/29619746


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0601", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biochemistry and Cell Biology", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biological Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Line", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Survival", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Endoplasmic Reticulum Stress", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Fibroblasts", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Golgi Apparatus", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Lysosomes", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Stress, Physiological", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Telomerase", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Cairo University", 
          "id": "https://www.grid.ac/institutes/grid.7776.1", 
          "name": [
            "Department of Pharmacotherapy, Graduate School of Biomedical and Health Sciences, Hiroshima University, 1-2-3 Kasumi, Minami-ku, 734-8553, Hiroshima, Hiroshima, Japan", 
            "Global Career Design Center, Hiroshima University, 1-7-1 Kagamiyama, 739-8514, Higashi-Hiroshima City, Hiroshima, Japan", 
            "Pharmacology and Experimental Oncology Unit, Cancer Biology Department, National Cancer Institute, Cairo University, 11796, Cairo, Egypt"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Abd El-Hafeez", 
        "givenName": "Amer Ali", 
        "id": "sg:person.014441112513.02", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014441112513.02"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Hiroshima University", 
          "id": "https://www.grid.ac/institutes/grid.257022.0", 
          "name": [
            "Department of Pharmacotherapy, Graduate School of Biomedical and Health Sciences, Hiroshima University, 1-2-3 Kasumi, Minami-ku, 734-8553, Hiroshima, Hiroshima, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hosoi", 
        "givenName": "Toru", 
        "id": "sg:person.01354317040.40", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01354317040.40"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Hiroshima University", 
          "id": "https://www.grid.ac/institutes/grid.257022.0", 
          "name": [
            "Department of Pharmacotherapy, Graduate School of Biomedical and Health Sciences, Hiroshima University, 1-2-3 Kasumi, Minami-ku, 734-8553, Hiroshima, Hiroshima, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Nakatsu", 
        "givenName": "Kanako", 
        "id": "sg:person.0677026140.75", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0677026140.75"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Hiroshima University", 
          "id": "https://www.grid.ac/institutes/grid.257022.0", 
          "name": [
            "Department of Pharmacotherapy, Graduate School of Biomedical and Health Sciences, Hiroshima University, 1-2-3 Kasumi, Minami-ku, 734-8553, Hiroshima, Hiroshima, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Thon", 
        "givenName": "Mina", 
        "id": "sg:person.0652435472.54", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0652435472.54"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Hiroshima University", 
          "id": "https://www.grid.ac/institutes/grid.257022.0", 
          "name": [
            "Department of Cellular and Molecular Biology, Graduate School of Biomedical and Health Sciences, Hiroshima University, 1-2-3 Kasumi, Minami-ku, 734-8553, Hiroshima, Hiroshima, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Shimamoto", 
        "givenName": "Akira", 
        "id": "sg:person.01343417531.97", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01343417531.97"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Hiroshima University", 
          "id": "https://www.grid.ac/institutes/grid.257022.0", 
          "name": [
            "Department of Cellular and Molecular Biology, Graduate School of Biomedical and Health Sciences, Hiroshima University, 1-2-3 Kasumi, Minami-ku, 734-8553, Hiroshima, Hiroshima, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Tahara", 
        "givenName": "Hidetoshi", 
        "id": "sg:person.013245451372.31", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013245451372.31"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Hiroshima University", 
          "id": "https://www.grid.ac/institutes/grid.257022.0", 
          "name": [
            "Department of Pharmacotherapy, Graduate School of Biomedical and Health Sciences, Hiroshima University, 1-2-3 Kasumi, Minami-ku, 734-8553, Hiroshima, Hiroshima, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ozawa", 
        "givenName": "Koichiro", 
        "id": "sg:person.016653467252.76", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016653467252.76"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.5772/26118", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005544955"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s004180050256", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009252923", 
          "https://doi.org/10.1007/s004180050256"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1042/bj2190965", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009268022"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1042/bj2190965", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009268022"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ijdevneu.2008.05.006", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010535957"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.81.15.4960", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010713781"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.191169098", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012840403"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.onc.1205419", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014659565", 
          "https://doi.org/10.1038/sj.onc.1205419"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.onc.1205419", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014659565", 
          "https://doi.org/10.1038/sj.onc.1205419"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/carcin/bgp268", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015845298"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/carcin/bgp268", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015845298"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/mmbr.66.3.407-425.2002", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016236019"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/iub.1272", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018544066"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1146/annurev.pathmechdis.3.121806.151434", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019470563"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/alzrt217", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020655993", 
          "https://doi.org/10.1186/alzrt217"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1600-0854.2005.00317.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021576094"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1600-0854.2005.00317.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021576094"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/ijc.10592", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024817761"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3389/fnins.2015.00421", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032584259"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.mrfmmm.2004.06.056", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034135579"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.bbrc.2014.04.034", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034299272"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3389/fphys.2012.00263", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034582760"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1155/2010/214074", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034745152"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.neulet.2016.07.027", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036409870"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.bbagen.2008.01.009", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037390896"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/jb/mvv010", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042530375"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/b978-0-12-385114-7.00004-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042625075"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m610529200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046694706"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jchemneu.2003.12.004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050377482"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.15430/jcp.2014.19.2.75", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050953128"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.279.5349.349", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051728512"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.onc.1211037", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051735032", 
          "https://doi.org/10.1038/sj.onc.1211037"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1101/cshperspect.a013201", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052648826"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1080/15548627.2015.1110670", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1058406651"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3892/ijo.23.1.197", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1071515019"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082752966", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1247/csf.16023", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1083695701"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.r117.791061", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1090374713"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrm.2017.66", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1091107567", 
          "https://doi.org/10.1038/nrm.2017.66"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2018-06", 
    "datePublishedReg": "2018-06-01", 
    "description": "OBJECTIVE: The exposure of organelles, such as the endoplasmic reticulum (ER), Golgi apparatus (GA), and lysosomes, to stress activates death mechanisms. Recently, telomerase reverse transcriptase (TERT) has been shown to be involved in cell survival. However, the relationship between TERT and the stress responses is still unclear. Here, we aimed to clarify the possible mechanisms of action through which TERT promotes cell survival by studying its effect on the stresses faced by multiple organelles in human fibroblasts.\nRESULTS: We found that TERT enhanced the survival rate of cells under ER stress, regardless of ER stress inducers such as tunicamycin (protein glycosylation inhibitor), thapsigargin (Ca2+-ATPase inhibitor), brefeldin A (protein transport inhibitor), or dithiothreitol (disulfide bond formation inhibitor). We also found that TERT enhanced the survival rate of cells under GA and lysosomal stresses.\nCONCLUSION: Collectively, these results suggest that TERT suppresses cell stress and promotes cell survival via different mechanisms. These findings may offer new insights into the implications of TERT in the treatment of stress-induced conditions such as aging, obesity, and neurodegenerative diseases.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1007/s10529-018-2544-1", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1289037", 
        "issn": [
          "0951-208X", 
          "1573-6784"
        ], 
        "name": "Biotechnology Letters", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "6", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "40"
      }
    ], 
    "name": "TERT enhances the survival rate of human fibroblasts under endoplasmic reticulum, Golgi apparatus, and lysosomal stresses", 
    "pagination": "915-922", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "d2d6251393cacd25bb0d22fa3d91fa46cb636d70160332570d88c017b16662f0"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "29619746"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "8008051"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s10529-018-2544-1"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1103172478"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s10529-018-2544-1", 
      "https://app.dimensions.ai/details/publication/pub.1103172478"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T14:19", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000372_0000000372/records_117117_00000003.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://link.springer.com/10.1007%2Fs10529-018-2544-1"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s10529-018-2544-1'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s10529-018-2544-1'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s10529-018-2544-1'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s10529-018-2544-1'


 

This table displays all metadata directly associated to this object as RDF triples.

262 TRIPLES      21 PREDICATES      73 URIs      30 LITERALS      18 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s10529-018-2544-1 schema:about N44b401c8916d45c59eb788401bf58dda
2 N4f3cb7d994644e818958eb7ea8d14568
3 N820ba29c497b47d6b6173086db52dc9b
4 N84f7f63ecbb5451aa9f006350e15680e
5 N91b210616cef4c72ba78f640f4b5dca1
6 N92d83b1697f3447bbf42c4146f702a54
7 Naca8c78490724c909582b08c4b178832
8 Nb4553129516e479089e552eb42c1846f
9 Ne4478090c2064cb2ad9fc5e6795c2417
10 anzsrc-for:06
11 anzsrc-for:0601
12 schema:author N2ecea3ece3f346748a1b5ac58fd51dba
13 schema:citation sg:pub.10.1007/s004180050256
14 sg:pub.10.1038/nrm.2017.66
15 sg:pub.10.1038/sj.onc.1205419
16 sg:pub.10.1038/sj.onc.1211037
17 sg:pub.10.1186/alzrt217
18 https://app.dimensions.ai/details/publication/pub.1082752966
19 https://doi.org/10.1002/ijc.10592
20 https://doi.org/10.1002/iub.1272
21 https://doi.org/10.1016/b978-0-12-385114-7.00004-0
22 https://doi.org/10.1016/j.bbagen.2008.01.009
23 https://doi.org/10.1016/j.bbrc.2014.04.034
24 https://doi.org/10.1016/j.ijdevneu.2008.05.006
25 https://doi.org/10.1016/j.jchemneu.2003.12.004
26 https://doi.org/10.1016/j.mrfmmm.2004.06.056
27 https://doi.org/10.1016/j.neulet.2016.07.027
28 https://doi.org/10.1042/bj2190965
29 https://doi.org/10.1073/pnas.191169098
30 https://doi.org/10.1073/pnas.81.15.4960
31 https://doi.org/10.1074/jbc.m610529200
32 https://doi.org/10.1074/jbc.r117.791061
33 https://doi.org/10.1080/15548627.2015.1110670
34 https://doi.org/10.1093/carcin/bgp268
35 https://doi.org/10.1093/jb/mvv010
36 https://doi.org/10.1101/cshperspect.a013201
37 https://doi.org/10.1111/j.1600-0854.2005.00317.x
38 https://doi.org/10.1126/science.279.5349.349
39 https://doi.org/10.1128/mmbr.66.3.407-425.2002
40 https://doi.org/10.1146/annurev.pathmechdis.3.121806.151434
41 https://doi.org/10.1155/2010/214074
42 https://doi.org/10.1247/csf.16023
43 https://doi.org/10.15430/jcp.2014.19.2.75
44 https://doi.org/10.3389/fnins.2015.00421
45 https://doi.org/10.3389/fphys.2012.00263
46 https://doi.org/10.3892/ijo.23.1.197
47 https://doi.org/10.5772/26118
48 schema:datePublished 2018-06
49 schema:datePublishedReg 2018-06-01
50 schema:description OBJECTIVE: The exposure of organelles, such as the endoplasmic reticulum (ER), Golgi apparatus (GA), and lysosomes, to stress activates death mechanisms. Recently, telomerase reverse transcriptase (TERT) has been shown to be involved in cell survival. However, the relationship between TERT and the stress responses is still unclear. Here, we aimed to clarify the possible mechanisms of action through which TERT promotes cell survival by studying its effect on the stresses faced by multiple organelles in human fibroblasts. RESULTS: We found that TERT enhanced the survival rate of cells under ER stress, regardless of ER stress inducers such as tunicamycin (protein glycosylation inhibitor), thapsigargin (Ca2+-ATPase inhibitor), brefeldin A (protein transport inhibitor), or dithiothreitol (disulfide bond formation inhibitor). We also found that TERT enhanced the survival rate of cells under GA and lysosomal stresses. CONCLUSION: Collectively, these results suggest that TERT suppresses cell stress and promotes cell survival via different mechanisms. These findings may offer new insights into the implications of TERT in the treatment of stress-induced conditions such as aging, obesity, and neurodegenerative diseases.
51 schema:genre research_article
52 schema:inLanguage en
53 schema:isAccessibleForFree false
54 schema:isPartOf N9860392d75bf4cc0a464e7f378c338eb
55 Nc53e1e6566994f6a8417c3e7f921d0a8
56 sg:journal.1289037
57 schema:name TERT enhances the survival rate of human fibroblasts under endoplasmic reticulum, Golgi apparatus, and lysosomal stresses
58 schema:pagination 915-922
59 schema:productId N08478f77b62b4463a127999af34abacc
60 N7c711b6586414ae1adddba671cabfba5
61 N89a60535a0114c27b06740461084edb6
62 Ndc2d0e69b06149198f5572c338ed2870
63 Ndc5b37719d704a6086cd245765c11b60
64 schema:sameAs https://app.dimensions.ai/details/publication/pub.1103172478
65 https://doi.org/10.1007/s10529-018-2544-1
66 schema:sdDatePublished 2019-04-11T14:19
67 schema:sdLicense https://scigraph.springernature.com/explorer/license/
68 schema:sdPublisher Nca128f95688941369e79ee35770b872e
69 schema:url https://link.springer.com/10.1007%2Fs10529-018-2544-1
70 sgo:license sg:explorer/license/
71 sgo:sdDataset articles
72 rdf:type schema:ScholarlyArticle
73 N08478f77b62b4463a127999af34abacc schema:name pubmed_id
74 schema:value 29619746
75 rdf:type schema:PropertyValue
76 N208a9e3213b2403387c7e47a18823cda rdf:first sg:person.0652435472.54
77 rdf:rest N21c6c721976847609cfbd151c221fec7
78 N21c6c721976847609cfbd151c221fec7 rdf:first sg:person.01343417531.97
79 rdf:rest Na8c5472ff97945bdae5b8ea284b79396
80 N237e2f991b8a4ec0883a7c03bda942e5 rdf:first sg:person.016653467252.76
81 rdf:rest rdf:nil
82 N2c7c1bd9b3ab424e9167e8eee21616ab rdf:first sg:person.01354317040.40
83 rdf:rest N8ecf0f15fef848a880e0f6f9284044d5
84 N2ecea3ece3f346748a1b5ac58fd51dba rdf:first sg:person.014441112513.02
85 rdf:rest N2c7c1bd9b3ab424e9167e8eee21616ab
86 N44b401c8916d45c59eb788401bf58dda schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
87 schema:name Telomerase
88 rdf:type schema:DefinedTerm
89 N4f3cb7d994644e818958eb7ea8d14568 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
90 schema:name Stress, Physiological
91 rdf:type schema:DefinedTerm
92 N7c711b6586414ae1adddba671cabfba5 schema:name nlm_unique_id
93 schema:value 8008051
94 rdf:type schema:PropertyValue
95 N820ba29c497b47d6b6173086db52dc9b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
96 schema:name Humans
97 rdf:type schema:DefinedTerm
98 N84f7f63ecbb5451aa9f006350e15680e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
99 schema:name Endoplasmic Reticulum Stress
100 rdf:type schema:DefinedTerm
101 N89a60535a0114c27b06740461084edb6 schema:name doi
102 schema:value 10.1007/s10529-018-2544-1
103 rdf:type schema:PropertyValue
104 N8ecf0f15fef848a880e0f6f9284044d5 rdf:first sg:person.0677026140.75
105 rdf:rest N208a9e3213b2403387c7e47a18823cda
106 N91b210616cef4c72ba78f640f4b5dca1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
107 schema:name Cell Survival
108 rdf:type schema:DefinedTerm
109 N92d83b1697f3447bbf42c4146f702a54 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
110 schema:name Lysosomes
111 rdf:type schema:DefinedTerm
112 N9860392d75bf4cc0a464e7f378c338eb schema:issueNumber 6
113 rdf:type schema:PublicationIssue
114 Na8c5472ff97945bdae5b8ea284b79396 rdf:first sg:person.013245451372.31
115 rdf:rest N237e2f991b8a4ec0883a7c03bda942e5
116 Naca8c78490724c909582b08c4b178832 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
117 schema:name Golgi Apparatus
118 rdf:type schema:DefinedTerm
119 Nb4553129516e479089e552eb42c1846f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
120 schema:name Fibroblasts
121 rdf:type schema:DefinedTerm
122 Nc53e1e6566994f6a8417c3e7f921d0a8 schema:volumeNumber 40
123 rdf:type schema:PublicationVolume
124 Nca128f95688941369e79ee35770b872e schema:name Springer Nature - SN SciGraph project
125 rdf:type schema:Organization
126 Ndc2d0e69b06149198f5572c338ed2870 schema:name readcube_id
127 schema:value d2d6251393cacd25bb0d22fa3d91fa46cb636d70160332570d88c017b16662f0
128 rdf:type schema:PropertyValue
129 Ndc5b37719d704a6086cd245765c11b60 schema:name dimensions_id
130 schema:value pub.1103172478
131 rdf:type schema:PropertyValue
132 Ne4478090c2064cb2ad9fc5e6795c2417 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
133 schema:name Cell Line
134 rdf:type schema:DefinedTerm
135 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
136 schema:name Biological Sciences
137 rdf:type schema:DefinedTerm
138 anzsrc-for:0601 schema:inDefinedTermSet anzsrc-for:
139 schema:name Biochemistry and Cell Biology
140 rdf:type schema:DefinedTerm
141 sg:journal.1289037 schema:issn 0951-208X
142 1573-6784
143 schema:name Biotechnology Letters
144 rdf:type schema:Periodical
145 sg:person.013245451372.31 schema:affiliation https://www.grid.ac/institutes/grid.257022.0
146 schema:familyName Tahara
147 schema:givenName Hidetoshi
148 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013245451372.31
149 rdf:type schema:Person
150 sg:person.01343417531.97 schema:affiliation https://www.grid.ac/institutes/grid.257022.0
151 schema:familyName Shimamoto
152 schema:givenName Akira
153 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01343417531.97
154 rdf:type schema:Person
155 sg:person.01354317040.40 schema:affiliation https://www.grid.ac/institutes/grid.257022.0
156 schema:familyName Hosoi
157 schema:givenName Toru
158 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01354317040.40
159 rdf:type schema:Person
160 sg:person.014441112513.02 schema:affiliation https://www.grid.ac/institutes/grid.7776.1
161 schema:familyName Abd El-Hafeez
162 schema:givenName Amer Ali
163 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014441112513.02
164 rdf:type schema:Person
165 sg:person.016653467252.76 schema:affiliation https://www.grid.ac/institutes/grid.257022.0
166 schema:familyName Ozawa
167 schema:givenName Koichiro
168 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016653467252.76
169 rdf:type schema:Person
170 sg:person.0652435472.54 schema:affiliation https://www.grid.ac/institutes/grid.257022.0
171 schema:familyName Thon
172 schema:givenName Mina
173 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0652435472.54
174 rdf:type schema:Person
175 sg:person.0677026140.75 schema:affiliation https://www.grid.ac/institutes/grid.257022.0
176 schema:familyName Nakatsu
177 schema:givenName Kanako
178 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0677026140.75
179 rdf:type schema:Person
180 sg:pub.10.1007/s004180050256 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009252923
181 https://doi.org/10.1007/s004180050256
182 rdf:type schema:CreativeWork
183 sg:pub.10.1038/nrm.2017.66 schema:sameAs https://app.dimensions.ai/details/publication/pub.1091107567
184 https://doi.org/10.1038/nrm.2017.66
185 rdf:type schema:CreativeWork
186 sg:pub.10.1038/sj.onc.1205419 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014659565
187 https://doi.org/10.1038/sj.onc.1205419
188 rdf:type schema:CreativeWork
189 sg:pub.10.1038/sj.onc.1211037 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051735032
190 https://doi.org/10.1038/sj.onc.1211037
191 rdf:type schema:CreativeWork
192 sg:pub.10.1186/alzrt217 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020655993
193 https://doi.org/10.1186/alzrt217
194 rdf:type schema:CreativeWork
195 https://app.dimensions.ai/details/publication/pub.1082752966 schema:CreativeWork
196 https://doi.org/10.1002/ijc.10592 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024817761
197 rdf:type schema:CreativeWork
198 https://doi.org/10.1002/iub.1272 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018544066
199 rdf:type schema:CreativeWork
200 https://doi.org/10.1016/b978-0-12-385114-7.00004-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042625075
201 rdf:type schema:CreativeWork
202 https://doi.org/10.1016/j.bbagen.2008.01.009 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037390896
203 rdf:type schema:CreativeWork
204 https://doi.org/10.1016/j.bbrc.2014.04.034 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034299272
205 rdf:type schema:CreativeWork
206 https://doi.org/10.1016/j.ijdevneu.2008.05.006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010535957
207 rdf:type schema:CreativeWork
208 https://doi.org/10.1016/j.jchemneu.2003.12.004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050377482
209 rdf:type schema:CreativeWork
210 https://doi.org/10.1016/j.mrfmmm.2004.06.056 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034135579
211 rdf:type schema:CreativeWork
212 https://doi.org/10.1016/j.neulet.2016.07.027 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036409870
213 rdf:type schema:CreativeWork
214 https://doi.org/10.1042/bj2190965 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009268022
215 rdf:type schema:CreativeWork
216 https://doi.org/10.1073/pnas.191169098 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012840403
217 rdf:type schema:CreativeWork
218 https://doi.org/10.1073/pnas.81.15.4960 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010713781
219 rdf:type schema:CreativeWork
220 https://doi.org/10.1074/jbc.m610529200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046694706
221 rdf:type schema:CreativeWork
222 https://doi.org/10.1074/jbc.r117.791061 schema:sameAs https://app.dimensions.ai/details/publication/pub.1090374713
223 rdf:type schema:CreativeWork
224 https://doi.org/10.1080/15548627.2015.1110670 schema:sameAs https://app.dimensions.ai/details/publication/pub.1058406651
225 rdf:type schema:CreativeWork
226 https://doi.org/10.1093/carcin/bgp268 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015845298
227 rdf:type schema:CreativeWork
228 https://doi.org/10.1093/jb/mvv010 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042530375
229 rdf:type schema:CreativeWork
230 https://doi.org/10.1101/cshperspect.a013201 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052648826
231 rdf:type schema:CreativeWork
232 https://doi.org/10.1111/j.1600-0854.2005.00317.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1021576094
233 rdf:type schema:CreativeWork
234 https://doi.org/10.1126/science.279.5349.349 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051728512
235 rdf:type schema:CreativeWork
236 https://doi.org/10.1128/mmbr.66.3.407-425.2002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016236019
237 rdf:type schema:CreativeWork
238 https://doi.org/10.1146/annurev.pathmechdis.3.121806.151434 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019470563
239 rdf:type schema:CreativeWork
240 https://doi.org/10.1155/2010/214074 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034745152
241 rdf:type schema:CreativeWork
242 https://doi.org/10.1247/csf.16023 schema:sameAs https://app.dimensions.ai/details/publication/pub.1083695701
243 rdf:type schema:CreativeWork
244 https://doi.org/10.15430/jcp.2014.19.2.75 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050953128
245 rdf:type schema:CreativeWork
246 https://doi.org/10.3389/fnins.2015.00421 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032584259
247 rdf:type schema:CreativeWork
248 https://doi.org/10.3389/fphys.2012.00263 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034582760
249 rdf:type schema:CreativeWork
250 https://doi.org/10.3892/ijo.23.1.197 schema:sameAs https://app.dimensions.ai/details/publication/pub.1071515019
251 rdf:type schema:CreativeWork
252 https://doi.org/10.5772/26118 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005544955
253 rdf:type schema:CreativeWork
254 https://www.grid.ac/institutes/grid.257022.0 schema:alternateName Hiroshima University
255 schema:name Department of Cellular and Molecular Biology, Graduate School of Biomedical and Health Sciences, Hiroshima University, 1-2-3 Kasumi, Minami-ku, 734-8553, Hiroshima, Hiroshima, Japan
256 Department of Pharmacotherapy, Graduate School of Biomedical and Health Sciences, Hiroshima University, 1-2-3 Kasumi, Minami-ku, 734-8553, Hiroshima, Hiroshima, Japan
257 rdf:type schema:Organization
258 https://www.grid.ac/institutes/grid.7776.1 schema:alternateName Cairo University
259 schema:name Department of Pharmacotherapy, Graduate School of Biomedical and Health Sciences, Hiroshima University, 1-2-3 Kasumi, Minami-ku, 734-8553, Hiroshima, Hiroshima, Japan
260 Global Career Design Center, Hiroshima University, 1-7-1 Kagamiyama, 739-8514, Higashi-Hiroshima City, Hiroshima, Japan
261 Pharmacology and Experimental Oncology Unit, Cancer Biology Department, National Cancer Institute, Cairo University, 11796, Cairo, Egypt
262 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...