Ontology type: schema:ScholarlyArticle
2018-06
AUTHORSAmer Ali Abd El-Hafeez, Toru Hosoi, Kanako Nakatsu, Mina Thon, Akira Shimamoto, Hidetoshi Tahara, Koichiro Ozawa
ABSTRACTOBJECTIVE: The exposure of organelles, such as the endoplasmic reticulum (ER), Golgi apparatus (GA), and lysosomes, to stress activates death mechanisms. Recently, telomerase reverse transcriptase (TERT) has been shown to be involved in cell survival. However, the relationship between TERT and the stress responses is still unclear. Here, we aimed to clarify the possible mechanisms of action through which TERT promotes cell survival by studying its effect on the stresses faced by multiple organelles in human fibroblasts. RESULTS: We found that TERT enhanced the survival rate of cells under ER stress, regardless of ER stress inducers such as tunicamycin (protein glycosylation inhibitor), thapsigargin (Ca2+-ATPase inhibitor), brefeldin A (protein transport inhibitor), or dithiothreitol (disulfide bond formation inhibitor). We also found that TERT enhanced the survival rate of cells under GA and lysosomal stresses. CONCLUSION: Collectively, these results suggest that TERT suppresses cell stress and promotes cell survival via different mechanisms. These findings may offer new insights into the implications of TERT in the treatment of stress-induced conditions such as aging, obesity, and neurodegenerative diseases. More... »
PAGES915-922
http://scigraph.springernature.com/pub.10.1007/s10529-018-2544-1
DOIhttp://dx.doi.org/10.1007/s10529-018-2544-1
DIMENSIONShttps://app.dimensions.ai/details/publication/pub.1103172478
PUBMEDhttps://www.ncbi.nlm.nih.gov/pubmed/29619746
JSON-LD is the canonical representation for SciGraph data.
TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT
[
{
"@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json",
"about": [
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0601",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Biochemistry and Cell Biology",
"type": "DefinedTerm"
},
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Biological Sciences",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Cell Line",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Cell Survival",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Endoplasmic Reticulum Stress",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Fibroblasts",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Golgi Apparatus",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Humans",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Lysosomes",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Stress, Physiological",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Telomerase",
"type": "DefinedTerm"
}
],
"author": [
{
"affiliation": {
"alternateName": "Cairo University",
"id": "https://www.grid.ac/institutes/grid.7776.1",
"name": [
"Department of Pharmacotherapy, Graduate School of Biomedical and Health Sciences, Hiroshima University, 1-2-3 Kasumi, Minami-ku, 734-8553, Hiroshima, Hiroshima, Japan",
"Global Career Design Center, Hiroshima University, 1-7-1 Kagamiyama, 739-8514, Higashi-Hiroshima City, Hiroshima, Japan",
"Pharmacology and Experimental Oncology Unit, Cancer Biology Department, National Cancer Institute, Cairo University, 11796, Cairo, Egypt"
],
"type": "Organization"
},
"familyName": "Abd El-Hafeez",
"givenName": "Amer Ali",
"id": "sg:person.014441112513.02",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014441112513.02"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Hiroshima University",
"id": "https://www.grid.ac/institutes/grid.257022.0",
"name": [
"Department of Pharmacotherapy, Graduate School of Biomedical and Health Sciences, Hiroshima University, 1-2-3 Kasumi, Minami-ku, 734-8553, Hiroshima, Hiroshima, Japan"
],
"type": "Organization"
},
"familyName": "Hosoi",
"givenName": "Toru",
"id": "sg:person.01354317040.40",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01354317040.40"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Hiroshima University",
"id": "https://www.grid.ac/institutes/grid.257022.0",
"name": [
"Department of Pharmacotherapy, Graduate School of Biomedical and Health Sciences, Hiroshima University, 1-2-3 Kasumi, Minami-ku, 734-8553, Hiroshima, Hiroshima, Japan"
],
"type": "Organization"
},
"familyName": "Nakatsu",
"givenName": "Kanako",
"id": "sg:person.0677026140.75",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0677026140.75"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Hiroshima University",
"id": "https://www.grid.ac/institutes/grid.257022.0",
"name": [
"Department of Pharmacotherapy, Graduate School of Biomedical and Health Sciences, Hiroshima University, 1-2-3 Kasumi, Minami-ku, 734-8553, Hiroshima, Hiroshima, Japan"
],
"type": "Organization"
},
"familyName": "Thon",
"givenName": "Mina",
"id": "sg:person.0652435472.54",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0652435472.54"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Hiroshima University",
"id": "https://www.grid.ac/institutes/grid.257022.0",
"name": [
"Department of Cellular and Molecular Biology, Graduate School of Biomedical and Health Sciences, Hiroshima University, 1-2-3 Kasumi, Minami-ku, 734-8553, Hiroshima, Hiroshima, Japan"
],
"type": "Organization"
},
"familyName": "Shimamoto",
"givenName": "Akira",
"id": "sg:person.01343417531.97",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01343417531.97"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Hiroshima University",
"id": "https://www.grid.ac/institutes/grid.257022.0",
"name": [
"Department of Cellular and Molecular Biology, Graduate School of Biomedical and Health Sciences, Hiroshima University, 1-2-3 Kasumi, Minami-ku, 734-8553, Hiroshima, Hiroshima, Japan"
],
"type": "Organization"
},
"familyName": "Tahara",
"givenName": "Hidetoshi",
"id": "sg:person.013245451372.31",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013245451372.31"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Hiroshima University",
"id": "https://www.grid.ac/institutes/grid.257022.0",
"name": [
"Department of Pharmacotherapy, Graduate School of Biomedical and Health Sciences, Hiroshima University, 1-2-3 Kasumi, Minami-ku, 734-8553, Hiroshima, Hiroshima, Japan"
],
"type": "Organization"
},
"familyName": "Ozawa",
"givenName": "Koichiro",
"id": "sg:person.016653467252.76",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016653467252.76"
],
"type": "Person"
}
],
"citation": [
{
"id": "https://doi.org/10.5772/26118",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1005544955"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/s004180050256",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1009252923",
"https://doi.org/10.1007/s004180050256"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1042/bj2190965",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1009268022"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1042/bj2190965",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1009268022"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.ijdevneu.2008.05.006",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1010535957"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1073/pnas.81.15.4960",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1010713781"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1073/pnas.191169098",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1012840403"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/sj.onc.1205419",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1014659565",
"https://doi.org/10.1038/sj.onc.1205419"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/sj.onc.1205419",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1014659565",
"https://doi.org/10.1038/sj.onc.1205419"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1093/carcin/bgp268",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1015845298"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1093/carcin/bgp268",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1015845298"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1128/mmbr.66.3.407-425.2002",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1016236019"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1002/iub.1272",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1018544066"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1146/annurev.pathmechdis.3.121806.151434",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1019470563"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1186/alzrt217",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1020655993",
"https://doi.org/10.1186/alzrt217"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1111/j.1600-0854.2005.00317.x",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1021576094"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1111/j.1600-0854.2005.00317.x",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1021576094"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1002/ijc.10592",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1024817761"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.3389/fnins.2015.00421",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1032584259"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.mrfmmm.2004.06.056",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1034135579"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.bbrc.2014.04.034",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1034299272"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.3389/fphys.2012.00263",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1034582760"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1155/2010/214074",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1034745152"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.neulet.2016.07.027",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1036409870"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.bbagen.2008.01.009",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1037390896"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1093/jb/mvv010",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1042530375"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/b978-0-12-385114-7.00004-0",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1042625075"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1074/jbc.m610529200",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1046694706"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.jchemneu.2003.12.004",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1050377482"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.15430/jcp.2014.19.2.75",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1050953128"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1126/science.279.5349.349",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1051728512"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/sj.onc.1211037",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1051735032",
"https://doi.org/10.1038/sj.onc.1211037"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1101/cshperspect.a013201",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1052648826"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1080/15548627.2015.1110670",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1058406651"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.3892/ijo.23.1.197",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1071515019"
],
"type": "CreativeWork"
},
{
"id": "https://app.dimensions.ai/details/publication/pub.1082752966",
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1247/csf.16023",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1083695701"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1074/jbc.r117.791061",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1090374713"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nrm.2017.66",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1091107567",
"https://doi.org/10.1038/nrm.2017.66"
],
"type": "CreativeWork"
}
],
"datePublished": "2018-06",
"datePublishedReg": "2018-06-01",
"description": "OBJECTIVE: The exposure of organelles, such as the endoplasmic reticulum (ER), Golgi apparatus (GA), and lysosomes, to stress activates death mechanisms. Recently, telomerase reverse transcriptase (TERT) has been shown to be involved in cell survival. However, the relationship between TERT and the stress responses is still unclear. Here, we aimed to clarify the possible mechanisms of action through which TERT promotes cell survival by studying its effect on the stresses faced by multiple organelles in human fibroblasts.\nRESULTS: We found that TERT enhanced the survival rate of cells under ER stress, regardless of ER stress inducers such as tunicamycin (protein glycosylation inhibitor), thapsigargin (Ca2+-ATPase inhibitor), brefeldin A (protein transport inhibitor), or dithiothreitol (disulfide bond formation inhibitor). We also found that TERT enhanced the survival rate of cells under GA and lysosomal stresses.\nCONCLUSION: Collectively, these results suggest that TERT suppresses cell stress and promotes cell survival via different mechanisms. These findings may offer new insights into the implications of TERT in the treatment of stress-induced conditions such as aging, obesity, and neurodegenerative diseases.",
"genre": "research_article",
"id": "sg:pub.10.1007/s10529-018-2544-1",
"inLanguage": [
"en"
],
"isAccessibleForFree": false,
"isPartOf": [
{
"id": "sg:journal.1289037",
"issn": [
"0951-208X",
"1573-6784"
],
"name": "Biotechnology Letters",
"type": "Periodical"
},
{
"issueNumber": "6",
"type": "PublicationIssue"
},
{
"type": "PublicationVolume",
"volumeNumber": "40"
}
],
"name": "TERT enhances the survival rate of human fibroblasts under endoplasmic reticulum, Golgi apparatus, and lysosomal stresses",
"pagination": "915-922",
"productId": [
{
"name": "readcube_id",
"type": "PropertyValue",
"value": [
"d2d6251393cacd25bb0d22fa3d91fa46cb636d70160332570d88c017b16662f0"
]
},
{
"name": "pubmed_id",
"type": "PropertyValue",
"value": [
"29619746"
]
},
{
"name": "nlm_unique_id",
"type": "PropertyValue",
"value": [
"8008051"
]
},
{
"name": "doi",
"type": "PropertyValue",
"value": [
"10.1007/s10529-018-2544-1"
]
},
{
"name": "dimensions_id",
"type": "PropertyValue",
"value": [
"pub.1103172478"
]
}
],
"sameAs": [
"https://doi.org/10.1007/s10529-018-2544-1",
"https://app.dimensions.ai/details/publication/pub.1103172478"
],
"sdDataset": "articles",
"sdDatePublished": "2019-04-11T14:19",
"sdLicense": "https://scigraph.springernature.com/explorer/license/",
"sdPublisher": {
"name": "Springer Nature - SN SciGraph project",
"type": "Organization"
},
"sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000372_0000000372/records_117117_00000003.jsonl",
"type": "ScholarlyArticle",
"url": "https://link.springer.com/10.1007%2Fs10529-018-2544-1"
}
]
Download the RDF metadata as: json-ld nt turtle xml License info
JSON-LD is a popular format for linked data which is fully compatible with JSON.
curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s10529-018-2544-1'
N-Triples is a line-based linked data format ideal for batch operations.
curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s10529-018-2544-1'
Turtle is a human-readable linked data format.
curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s10529-018-2544-1'
RDF/XML is a standard XML format for linked data.
curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s10529-018-2544-1'
This table displays all metadata directly associated to this object as RDF triples.
262 TRIPLES
21 PREDICATES
73 URIs
30 LITERALS
18 BLANK NODES