Itaconic acid production in microorganisms View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2018-03

AUTHORS

Meilin Zhao, Xinyao Lu, Hong Zong, Jinyang Li, Bin Zhuge

ABSTRACT

Itaconic acid, 2-methylidenebutanedioic acid, is a precursor of polymers, chemicals, and fuels. Many fungi can synthesize itaconic acid; Aspergillus terreus and Ustilago maydis produce up to 85 and 53 g l-1, respectively. Other organisms, including Aspergillus niger and yeasts, have been engineered to produce itaconic acid. However, the titer of itaconic acid is low compared with the analogous major fermentation product, citric acid, for which the yield is > 200 g l-1. Here, we review two types of pathway for itaconic acid biosynthesis as well as recent advances by metabolic engineering strategies and process optimization to enhance itaconic acid productivity in native producers and heterologous hosts. We also propose further improvements to overcome existing problems. More... »

PAGES

455-464

References to SciGraph publications

  • 2017-01. Downstream process development in biotechnological itaconic acid manufacturing in APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
  • 2012-12. Enhanced itaconic acid production in Aspergillus niger using genetic modification and medium optimization in BMC BIOTECHNOLOGY
  • 2016-12. Rewiring a secondary metabolite pathway towards itaconic acid production in Aspergillus niger in MICROBIAL CELL FACTORIES
  • 2017-02. Emerging biotechnologies for production of itaconic acid and its applications as a platform chemical in JOURNAL OF INDUSTRIAL MICROBIOLOGY & BIOTECHNOLOGY
  • 2004-07. Intracellular expression of Vitreoscilla hemoglobin in Aspergillus terreus to alleviate the effect of a short break in aeration during culture in BIOTECHNOLOGY LETTERS
  • 2008-08. Cloning and functional characterization of the cis-aconitic acid decarboxylase (CAD) gene from Aspergillus terreus in APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
  • 2014-12. Expression of the Aspergillus terreus itaconic acid biosynthesis cluster in Aspergillus niger in MICROBIAL CELL FACTORIES
  • 2004. Organic Acid Production by Filamentous Fungi in ADVANCES IN FUNGAL BIOTECHNOLOGY FOR INDUSTRY, AGRICULTURE, AND MEDICINE
  • 1990-04. Itaconic acid production from xylose in repeated-batch and continuous bioreactors in APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
  • 2010-08. Enhancing itaconic acid production by Aspergillus terreus in APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
  • 2017-01. A new technique for promoting cyclic utilization of cyclodextrins in biotransformation in JOURNAL OF INDUSTRIAL MICROBIOLOGY & BIOTECHNOLOGY
  • 2014-12. Direct production of itaconic acid from liquefied corn starch by genetically engineered Aspergillus terreus in MICROBIAL CELL FACTORIES
  • 2017-12. Efficient itaconic acid production from glycerol with Ustilago vetiveriae TZ1 in BIOTECHNOLOGY FOR BIOFUELS
  • 2012-12. Microbial production of itaconic acid: developing a stable platform for high product concentrations in APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
  • 2001-08. Biotechnological production of itaconic acid in APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
  • 2013-12. Overexpression of a modified 6-phosphofructo-1-kinase results in an increased itaconic acid productivity in Aspergillus niger in AMB EXPRESS
  • 2015-10. Regulating Pyruvate Carboxylase in the Living Culture of Aspergillus Terreus Nrrl 1960 by l-Aspartate for Enhanced Itaconic Acid Production in APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY
  • 1985-03. Itaconic acid production by immobilizedAspergillus terreus from xylose and glucose in BIOTECHNOLOGY LETTERS
  • 2015-10. A deficiency of manganese ions in the presence of high sugar concentrations is the critical parameter for achieving high yields of itaconic acid by Aspergillus terreus in APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
  • 2014-10. Metabolic engineering of Saccharomyces cerevisiae for itaconic acid production in APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
  • 2013-01. Six novel constitutive promoters for metabolic engineering of Aspergillus niger in APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
  • 2013-05. Reduced by-product formation and modified oxygen availability improve itaconic acid production in Aspergillus niger in APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
  • 2014-12. Improving itaconic acid production through genetic engineering of an industrial Aspergillus terreus strain in MICROBIAL CELL FACTORIES
  • 2015-01. Metabolic engineering of itaconate production in Escherichia coli in APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
  • 2014-12. Influence of the pH on the itaconic acid production with Aspergillus terreus in APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
  • 1992-03. ImmobilizedAspergillus terreus in itaconic acid production from glucose in BIOTECHNOLOGY LETTERS
  • 2009-09. Biotechnological production of itaconic acid and its biosynthesis in Aspergillus terreus in APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/s10529-017-2500-5

    DOI

    http://dx.doi.org/10.1007/s10529-017-2500-5

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1100160721

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/29299715


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0605", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Microbiology", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Biological Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Aspergillus", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Bioreactors", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Metabolic Engineering", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Metabolic Networks and Pathways", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Succinates", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Ustilago", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "Jiangnan University", 
              "id": "https://www.grid.ac/institutes/grid.258151.a", 
              "name": [
                "The Key Laboratory of Carbohydrate Chemistry and Biotechnology, Ministry of Education, School of Biotechnology, Jiangnan University, 214122, Wuxi, China", 
                "The Key Laboratory of Industrial Biotechnology, Ministry of Education, School of Biotechnology, Jiangnan University, 214122, Wuxi, China"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Zhao", 
            "givenName": "Meilin", 
            "id": "sg:person.011231123444.50", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011231123444.50"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Jiangnan University", 
              "id": "https://www.grid.ac/institutes/grid.258151.a", 
              "name": [
                "The Key Laboratory of Carbohydrate Chemistry and Biotechnology, Ministry of Education, School of Biotechnology, Jiangnan University, 214122, Wuxi, China", 
                "The Key Laboratory of Industrial Biotechnology, Ministry of Education, School of Biotechnology, Jiangnan University, 214122, Wuxi, China"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Lu", 
            "givenName": "Xinyao", 
            "id": "sg:person.0621020216.39", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0621020216.39"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Jiangnan University", 
              "id": "https://www.grid.ac/institutes/grid.258151.a", 
              "name": [
                "The Key Laboratory of Carbohydrate Chemistry and Biotechnology, Ministry of Education, School of Biotechnology, Jiangnan University, 214122, Wuxi, China", 
                "The Key Laboratory of Industrial Biotechnology, Ministry of Education, School of Biotechnology, Jiangnan University, 214122, Wuxi, China"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Zong", 
            "givenName": "Hong", 
            "id": "sg:person.01062447260.21", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01062447260.21"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Jiangnan University", 
              "id": "https://www.grid.ac/institutes/grid.258151.a", 
              "name": [
                "The Key Laboratory of Carbohydrate Chemistry and Biotechnology, Ministry of Education, School of Biotechnology, Jiangnan University, 214122, Wuxi, China", 
                "The Key Laboratory of Industrial Biotechnology, Ministry of Education, School of Biotechnology, Jiangnan University, 214122, Wuxi, China"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Li", 
            "givenName": "Jinyang", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Jiangnan University", 
              "id": "https://www.grid.ac/institutes/grid.258151.a", 
              "name": [
                "The Key Laboratory of Carbohydrate Chemistry and Biotechnology, Ministry of Education, School of Biotechnology, Jiangnan University, 214122, Wuxi, China", 
                "The Key Laboratory of Industrial Biotechnology, Ministry of Education, School of Biotechnology, Jiangnan University, 214122, Wuxi, China"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Zhuge", 
            "givenName": "Bin", 
            "id": "sg:person.01363472303.13", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01363472303.13"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "sg:pub.10.1186/s12934-016-0527-2", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000414445", 
              "https://doi.org/10.1186/s12934-016-0527-2"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/s12934-016-0527-2", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000414445", 
              "https://doi.org/10.1186/s12934-016-0527-2"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.biortech.2006.03.016", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002091828"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.ymben.2016.05.008", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002299708"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/1475-2859-13-11", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002522366", 
              "https://doi.org/10.1186/1475-2859-13-11"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/bit.25914", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002798115"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s1389-1723(02)80112-8", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003014735"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/bf01023359", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004065425", 
              "https://doi.org/10.1007/bf01023359"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00253-010-2642-z", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006572659", 
              "https://doi.org/10.1007/s00253-010-2642-z"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00253-010-2642-z", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006572659", 
              "https://doi.org/10.1007/s00253-010-2642-z"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.ymben.2016.02.003", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007407321"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1128/aem.05763-11", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010190642"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/1472-6750-12-57", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011782427", 
              "https://doi.org/10.1186/1472-6750-12-57"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.biortech.2012.11.141", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013582041"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/anie.201002060", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013746753"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/anie.201002060", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013746753"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/s12934-014-0119-y", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015332337", 
              "https://doi.org/10.1186/s12934-014-0119-y"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/s12934-014-0119-y", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015332337", 
              "https://doi.org/10.1186/s12934-014-0119-y"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.enzmictec.2006.01.005", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015566976"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.ymben.2015.09.005", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015624735"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0922-338x(93)90067-i", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020703607"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0922-338x(93)90067-i", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020703607"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/bf00170560", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020800122", 
              "https://doi.org/10.1007/bf00170560"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/bf00170560", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020800122", 
              "https://doi.org/10.1007/bf00170560"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1146/annurev-nutr-071714-034243", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021784640"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.3389/fmicb.2013.00023", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022942643"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00253-012-4221-y", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023435139", 
              "https://doi.org/10.1007/s00253-012-4221-y"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.ymben.2015.06.003", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023776968"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s002530100685", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023793698", 
              "https://doi.org/10.1007/s002530100685"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1271/bbb1961.45.475", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024907795"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0960-8524(02)00075-5", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1025331186"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s10295-016-1878-8", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026376027", 
              "https://doi.org/10.1007/s10295-016-1878-8"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s10295-016-1878-8", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026376027", 
              "https://doi.org/10.1007/s10295-016-1878-8"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00253-012-4207-9", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027210655", 
              "https://doi.org/10.1007/s00253-012-4207-9"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s10295-016-1856-1", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027744197", 
              "https://doi.org/10.1007/s10295-016-1856-1"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s10295-016-1856-1", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027744197", 
              "https://doi.org/10.1007/s10295-016-1856-1"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00253-008-1523-1", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028873842", 
              "https://doi.org/10.1007/s00253-008-1523-1"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00253-008-1523-1", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028873842", 
              "https://doi.org/10.1007/s00253-008-1523-1"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1046/j.1365-2672.1999.00528.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029938241"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1046/j.1365-2672.1999.00528.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029938241"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00253-014-6092-x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030116486", 
              "https://doi.org/10.1007/s00253-014-6092-x"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/bit.26081", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030892320"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00253-014-6047-2", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034550129", 
              "https://doi.org/10.1007/s00253-014-6047-2"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/bf01027812", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034561140", 
              "https://doi.org/10.1007/bf01027812"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/1751-7915.12329", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035093742"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/978-1-4419-8859-1_12", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035818671", 
              "https://doi.org/10.1007/978-1-4419-8859-1_12"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1128/jb.05465-11", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037349989"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00253-014-5895-0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037909762", 
              "https://doi.org/10.1007/s00253-014-5895-0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/2191-0855-3-57", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038870321", 
              "https://doi.org/10.1186/2191-0855-3-57"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.tim.2007.08.004", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039219765"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1042/bj0331488", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039449255"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1042/bj0331488", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039449255"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1139/m55-089", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039923383"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.2323/jgam.60.191", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040889615"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/elsc.201300043", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041364918"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00253-012-4684-x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043695129", 
              "https://doi.org/10.1007/s00253-012-4684-x"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0922-338x(97)89265-3", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044873486"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00253-009-2132-3", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045879219", 
              "https://doi.org/10.1007/s00253-009-2132-3"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00253-009-2132-3", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045879219", 
              "https://doi.org/10.1007/s00253-009-2132-3"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00253-009-2132-3", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045879219", 
              "https://doi.org/10.1007/s00253-009-2132-3"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.fgb.2011.01.013", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047621184"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1023/b:bile.0000032964.15178.7c", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048062009", 
              "https://doi.org/10.1023/b:bile.0000032964.15178.7c"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00253-016-7972-z", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049263738", 
              "https://doi.org/10.1007/s00253-016-7972-z"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00253-016-7972-z", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049263738", 
              "https://doi.org/10.1007/s00253-016-7972-z"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s12010-015-1763-3", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049779610", 
              "https://doi.org/10.1007/s12010-015-1763-3"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00253-015-6735-6", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049793758", 
              "https://doi.org/10.1007/s00253-015-6735-6"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/s12934-014-0108-1", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050038525", 
              "https://doi.org/10.1186/s12934-014-0108-1"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/s12934-014-0108-1", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050038525", 
              "https://doi.org/10.1186/s12934-014-0108-1"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.ymben.2013.05.003", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051320691"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1099/00221287-137-3-533", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1060367948"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1075736259", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1128/aem.03222-16", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1079392100"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/btpr.2485", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1085213499"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1080/07388551.2017.1312268", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1085242550"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/s13068-017-0809-x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1085444236", 
              "https://doi.org/10.1186/s13068-017-0809-x"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/s13068-017-0809-x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1085444236", 
              "https://doi.org/10.1186/s13068-017-0809-x"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/bit.26446", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1091424822"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/lam.12810", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1092058775"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.19026/crjbs.7.5205", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1100934203"
            ], 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2018-03", 
        "datePublishedReg": "2018-03-01", 
        "description": "Itaconic acid, 2-methylidenebutanedioic acid, is a precursor of polymers, chemicals, and fuels. Many fungi can synthesize itaconic acid; Aspergillus terreus and Ustilago maydis produce up to 85 and 53\u00a0g\u00a0l-1, respectively. Other organisms, including Aspergillus niger and yeasts, have been engineered to produce itaconic acid. However, the titer of itaconic acid is low compared with the analogous major fermentation product, citric acid, for which the yield is >\u00a0200\u00a0g\u00a0l-1. Here, we review two types of pathway for itaconic acid biosynthesis as well as recent advances by metabolic engineering strategies and process optimization to enhance itaconic acid productivity in native producers and heterologous hosts. We also propose further improvements to overcome existing problems.", 
        "genre": "research_article", 
        "id": "sg:pub.10.1007/s10529-017-2500-5", 
        "inLanguage": [
          "en"
        ], 
        "isAccessibleForFree": false, 
        "isPartOf": [
          {
            "id": "sg:journal.1289037", 
            "issn": [
              "0951-208X", 
              "1573-6784"
            ], 
            "name": "Biotechnology Letters", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "3", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "40"
          }
        ], 
        "name": "Itaconic acid production in microorganisms", 
        "pagination": "455-464", 
        "productId": [
          {
            "name": "readcube_id", 
            "type": "PropertyValue", 
            "value": [
              "209bc0cc2b54cb0f754efde878595f53160c6a557ef1e2d089f83043123adeb2"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "29299715"
            ]
          }, 
          {
            "name": "nlm_unique_id", 
            "type": "PropertyValue", 
            "value": [
              "8008051"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1007/s10529-017-2500-5"
            ]
          }, 
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1100160721"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1007/s10529-017-2500-5", 
          "https://app.dimensions.ai/details/publication/pub.1100160721"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2019-04-10T19:21", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8678_00000603.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "http://link.springer.com/10.1007/s10529-017-2500-5"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s10529-017-2500-5'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s10529-017-2500-5'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s10529-017-2500-5'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s10529-017-2500-5'


     

    This table displays all metadata directly associated to this object as RDF triples.

    336 TRIPLES      21 PREDICATES      98 URIs      27 LITERALS      15 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1007/s10529-017-2500-5 schema:about N265db68eb3da46bb9772b94242fb075e
    2 N50de29adabbe485c800e2b25d1dbf073
    3 N52768ce3210146bca79db45406756fdc
    4 N6983c4e784774d4a81c6e65a905e8b6d
    5 Nab59cb519d294944bdb7508f24ac7438
    6 Ncdcb5eed521e48d183f9cb751b62fdd1
    7 anzsrc-for:06
    8 anzsrc-for:0605
    9 schema:author N50676b7060e14b6d9a509caec8b47353
    10 schema:citation sg:pub.10.1007/978-1-4419-8859-1_12
    11 sg:pub.10.1007/bf00170560
    12 sg:pub.10.1007/bf01023359
    13 sg:pub.10.1007/bf01027812
    14 sg:pub.10.1007/s00253-008-1523-1
    15 sg:pub.10.1007/s00253-009-2132-3
    16 sg:pub.10.1007/s00253-010-2642-z
    17 sg:pub.10.1007/s00253-012-4207-9
    18 sg:pub.10.1007/s00253-012-4221-y
    19 sg:pub.10.1007/s00253-012-4684-x
    20 sg:pub.10.1007/s00253-014-5895-0
    21 sg:pub.10.1007/s00253-014-6047-2
    22 sg:pub.10.1007/s00253-014-6092-x
    23 sg:pub.10.1007/s00253-015-6735-6
    24 sg:pub.10.1007/s00253-016-7972-z
    25 sg:pub.10.1007/s002530100685
    26 sg:pub.10.1007/s10295-016-1856-1
    27 sg:pub.10.1007/s10295-016-1878-8
    28 sg:pub.10.1007/s12010-015-1763-3
    29 sg:pub.10.1023/b:bile.0000032964.15178.7c
    30 sg:pub.10.1186/1472-6750-12-57
    31 sg:pub.10.1186/1475-2859-13-11
    32 sg:pub.10.1186/2191-0855-3-57
    33 sg:pub.10.1186/s12934-014-0108-1
    34 sg:pub.10.1186/s12934-014-0119-y
    35 sg:pub.10.1186/s12934-016-0527-2
    36 sg:pub.10.1186/s13068-017-0809-x
    37 https://app.dimensions.ai/details/publication/pub.1075736259
    38 https://doi.org/10.1002/anie.201002060
    39 https://doi.org/10.1002/bit.25914
    40 https://doi.org/10.1002/bit.26081
    41 https://doi.org/10.1002/bit.26446
    42 https://doi.org/10.1002/btpr.2485
    43 https://doi.org/10.1002/elsc.201300043
    44 https://doi.org/10.1016/0922-338x(93)90067-i
    45 https://doi.org/10.1016/j.biortech.2006.03.016
    46 https://doi.org/10.1016/j.biortech.2012.11.141
    47 https://doi.org/10.1016/j.enzmictec.2006.01.005
    48 https://doi.org/10.1016/j.fgb.2011.01.013
    49 https://doi.org/10.1016/j.tim.2007.08.004
    50 https://doi.org/10.1016/j.ymben.2013.05.003
    51 https://doi.org/10.1016/j.ymben.2015.06.003
    52 https://doi.org/10.1016/j.ymben.2015.09.005
    53 https://doi.org/10.1016/j.ymben.2016.02.003
    54 https://doi.org/10.1016/j.ymben.2016.05.008
    55 https://doi.org/10.1016/s0922-338x(97)89265-3
    56 https://doi.org/10.1016/s0960-8524(02)00075-5
    57 https://doi.org/10.1016/s1389-1723(02)80112-8
    58 https://doi.org/10.1042/bj0331488
    59 https://doi.org/10.1046/j.1365-2672.1999.00528.x
    60 https://doi.org/10.1080/07388551.2017.1312268
    61 https://doi.org/10.1099/00221287-137-3-533
    62 https://doi.org/10.1111/1751-7915.12329
    63 https://doi.org/10.1111/lam.12810
    64 https://doi.org/10.1128/aem.03222-16
    65 https://doi.org/10.1128/aem.05763-11
    66 https://doi.org/10.1128/jb.05465-11
    67 https://doi.org/10.1139/m55-089
    68 https://doi.org/10.1146/annurev-nutr-071714-034243
    69 https://doi.org/10.1271/bbb1961.45.475
    70 https://doi.org/10.19026/crjbs.7.5205
    71 https://doi.org/10.2323/jgam.60.191
    72 https://doi.org/10.3389/fmicb.2013.00023
    73 schema:datePublished 2018-03
    74 schema:datePublishedReg 2018-03-01
    75 schema:description Itaconic acid, 2-methylidenebutanedioic acid, is a precursor of polymers, chemicals, and fuels. Many fungi can synthesize itaconic acid; Aspergillus terreus and Ustilago maydis produce up to 85 and 53 g l<sup>-1</sup>, respectively. Other organisms, including Aspergillus niger and yeasts, have been engineered to produce itaconic acid. However, the titer of itaconic acid is low compared with the analogous major fermentation product, citric acid, for which the yield is &gt; 200 g l<sup>-1</sup>. Here, we review two types of pathway for itaconic acid biosynthesis as well as recent advances by metabolic engineering strategies and process optimization to enhance itaconic acid productivity in native producers and heterologous hosts. We also propose further improvements to overcome existing problems.
    76 schema:genre research_article
    77 schema:inLanguage en
    78 schema:isAccessibleForFree false
    79 schema:isPartOf N9959baa1a2284a258aa8f5b30bf05bf0
    80 Ne2e52fad08304d8b81b40450b098bcfe
    81 sg:journal.1289037
    82 schema:name Itaconic acid production in microorganisms
    83 schema:pagination 455-464
    84 schema:productId N0a2c89c802634dff8328937e2df1acc9
    85 N0aa9bc62718c465e84fb158b6149694d
    86 N2ffede91ecc14e72ac54839b7ba2adbb
    87 N507416839a9b481d9f078deb25df58df
    88 Nf34ba6dfe9c44991bde76e3a307be4f4
    89 schema:sameAs https://app.dimensions.ai/details/publication/pub.1100160721
    90 https://doi.org/10.1007/s10529-017-2500-5
    91 schema:sdDatePublished 2019-04-10T19:21
    92 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    93 schema:sdPublisher N5d852e46bb2d4d368e749a97884f5e4a
    94 schema:url http://link.springer.com/10.1007/s10529-017-2500-5
    95 sgo:license sg:explorer/license/
    96 sgo:sdDataset articles
    97 rdf:type schema:ScholarlyArticle
    98 N0a2c89c802634dff8328937e2df1acc9 schema:name readcube_id
    99 schema:value 209bc0cc2b54cb0f754efde878595f53160c6a557ef1e2d089f83043123adeb2
    100 rdf:type schema:PropertyValue
    101 N0aa9bc62718c465e84fb158b6149694d schema:name pubmed_id
    102 schema:value 29299715
    103 rdf:type schema:PropertyValue
    104 N265db68eb3da46bb9772b94242fb075e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    105 schema:name Aspergillus
    106 rdf:type schema:DefinedTerm
    107 N2ffede91ecc14e72ac54839b7ba2adbb schema:name nlm_unique_id
    108 schema:value 8008051
    109 rdf:type schema:PropertyValue
    110 N50676b7060e14b6d9a509caec8b47353 rdf:first sg:person.011231123444.50
    111 rdf:rest Nafe957306731495db38e2ececfdff4f4
    112 N507416839a9b481d9f078deb25df58df schema:name dimensions_id
    113 schema:value pub.1100160721
    114 rdf:type schema:PropertyValue
    115 N50de29adabbe485c800e2b25d1dbf073 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    116 schema:name Ustilago
    117 rdf:type schema:DefinedTerm
    118 N52768ce3210146bca79db45406756fdc schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    119 schema:name Metabolic Engineering
    120 rdf:type schema:DefinedTerm
    121 N5d852e46bb2d4d368e749a97884f5e4a schema:name Springer Nature - SN SciGraph project
    122 rdf:type schema:Organization
    123 N6983c4e784774d4a81c6e65a905e8b6d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    124 schema:name Succinates
    125 rdf:type schema:DefinedTerm
    126 N9959baa1a2284a258aa8f5b30bf05bf0 schema:issueNumber 3
    127 rdf:type schema:PublicationIssue
    128 Nab59cb519d294944bdb7508f24ac7438 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    129 schema:name Metabolic Networks and Pathways
    130 rdf:type schema:DefinedTerm
    131 Nafe957306731495db38e2ececfdff4f4 rdf:first sg:person.0621020216.39
    132 rdf:rest Nafffb121c3e04e2484d9c7fe525e8326
    133 Nafffb121c3e04e2484d9c7fe525e8326 rdf:first sg:person.01062447260.21
    134 rdf:rest Nb4dd8b45f24044008b4374b4b2bab22e
    135 Nb4dd8b45f24044008b4374b4b2bab22e rdf:first Nd7af90ae6d684f34b4683b3bfb9aaa8e
    136 rdf:rest Nbbc5e63517f74704b287ddccea76e5e9
    137 Nbbc5e63517f74704b287ddccea76e5e9 rdf:first sg:person.01363472303.13
    138 rdf:rest rdf:nil
    139 Ncdcb5eed521e48d183f9cb751b62fdd1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    140 schema:name Bioreactors
    141 rdf:type schema:DefinedTerm
    142 Nd7af90ae6d684f34b4683b3bfb9aaa8e schema:affiliation https://www.grid.ac/institutes/grid.258151.a
    143 schema:familyName Li
    144 schema:givenName Jinyang
    145 rdf:type schema:Person
    146 Ne2e52fad08304d8b81b40450b098bcfe schema:volumeNumber 40
    147 rdf:type schema:PublicationVolume
    148 Nf34ba6dfe9c44991bde76e3a307be4f4 schema:name doi
    149 schema:value 10.1007/s10529-017-2500-5
    150 rdf:type schema:PropertyValue
    151 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
    152 schema:name Biological Sciences
    153 rdf:type schema:DefinedTerm
    154 anzsrc-for:0605 schema:inDefinedTermSet anzsrc-for:
    155 schema:name Microbiology
    156 rdf:type schema:DefinedTerm
    157 sg:journal.1289037 schema:issn 0951-208X
    158 1573-6784
    159 schema:name Biotechnology Letters
    160 rdf:type schema:Periodical
    161 sg:person.01062447260.21 schema:affiliation https://www.grid.ac/institutes/grid.258151.a
    162 schema:familyName Zong
    163 schema:givenName Hong
    164 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01062447260.21
    165 rdf:type schema:Person
    166 sg:person.011231123444.50 schema:affiliation https://www.grid.ac/institutes/grid.258151.a
    167 schema:familyName Zhao
    168 schema:givenName Meilin
    169 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011231123444.50
    170 rdf:type schema:Person
    171 sg:person.01363472303.13 schema:affiliation https://www.grid.ac/institutes/grid.258151.a
    172 schema:familyName Zhuge
    173 schema:givenName Bin
    174 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01363472303.13
    175 rdf:type schema:Person
    176 sg:person.0621020216.39 schema:affiliation https://www.grid.ac/institutes/grid.258151.a
    177 schema:familyName Lu
    178 schema:givenName Xinyao
    179 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0621020216.39
    180 rdf:type schema:Person
    181 sg:pub.10.1007/978-1-4419-8859-1_12 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035818671
    182 https://doi.org/10.1007/978-1-4419-8859-1_12
    183 rdf:type schema:CreativeWork
    184 sg:pub.10.1007/bf00170560 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020800122
    185 https://doi.org/10.1007/bf00170560
    186 rdf:type schema:CreativeWork
    187 sg:pub.10.1007/bf01023359 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004065425
    188 https://doi.org/10.1007/bf01023359
    189 rdf:type schema:CreativeWork
    190 sg:pub.10.1007/bf01027812 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034561140
    191 https://doi.org/10.1007/bf01027812
    192 rdf:type schema:CreativeWork
    193 sg:pub.10.1007/s00253-008-1523-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028873842
    194 https://doi.org/10.1007/s00253-008-1523-1
    195 rdf:type schema:CreativeWork
    196 sg:pub.10.1007/s00253-009-2132-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045879219
    197 https://doi.org/10.1007/s00253-009-2132-3
    198 rdf:type schema:CreativeWork
    199 sg:pub.10.1007/s00253-010-2642-z schema:sameAs https://app.dimensions.ai/details/publication/pub.1006572659
    200 https://doi.org/10.1007/s00253-010-2642-z
    201 rdf:type schema:CreativeWork
    202 sg:pub.10.1007/s00253-012-4207-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027210655
    203 https://doi.org/10.1007/s00253-012-4207-9
    204 rdf:type schema:CreativeWork
    205 sg:pub.10.1007/s00253-012-4221-y schema:sameAs https://app.dimensions.ai/details/publication/pub.1023435139
    206 https://doi.org/10.1007/s00253-012-4221-y
    207 rdf:type schema:CreativeWork
    208 sg:pub.10.1007/s00253-012-4684-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1043695129
    209 https://doi.org/10.1007/s00253-012-4684-x
    210 rdf:type schema:CreativeWork
    211 sg:pub.10.1007/s00253-014-5895-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037909762
    212 https://doi.org/10.1007/s00253-014-5895-0
    213 rdf:type schema:CreativeWork
    214 sg:pub.10.1007/s00253-014-6047-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034550129
    215 https://doi.org/10.1007/s00253-014-6047-2
    216 rdf:type schema:CreativeWork
    217 sg:pub.10.1007/s00253-014-6092-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1030116486
    218 https://doi.org/10.1007/s00253-014-6092-x
    219 rdf:type schema:CreativeWork
    220 sg:pub.10.1007/s00253-015-6735-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049793758
    221 https://doi.org/10.1007/s00253-015-6735-6
    222 rdf:type schema:CreativeWork
    223 sg:pub.10.1007/s00253-016-7972-z schema:sameAs https://app.dimensions.ai/details/publication/pub.1049263738
    224 https://doi.org/10.1007/s00253-016-7972-z
    225 rdf:type schema:CreativeWork
    226 sg:pub.10.1007/s002530100685 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023793698
    227 https://doi.org/10.1007/s002530100685
    228 rdf:type schema:CreativeWork
    229 sg:pub.10.1007/s10295-016-1856-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027744197
    230 https://doi.org/10.1007/s10295-016-1856-1
    231 rdf:type schema:CreativeWork
    232 sg:pub.10.1007/s10295-016-1878-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026376027
    233 https://doi.org/10.1007/s10295-016-1878-8
    234 rdf:type schema:CreativeWork
    235 sg:pub.10.1007/s12010-015-1763-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049779610
    236 https://doi.org/10.1007/s12010-015-1763-3
    237 rdf:type schema:CreativeWork
    238 sg:pub.10.1023/b:bile.0000032964.15178.7c schema:sameAs https://app.dimensions.ai/details/publication/pub.1048062009
    239 https://doi.org/10.1023/b:bile.0000032964.15178.7c
    240 rdf:type schema:CreativeWork
    241 sg:pub.10.1186/1472-6750-12-57 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011782427
    242 https://doi.org/10.1186/1472-6750-12-57
    243 rdf:type schema:CreativeWork
    244 sg:pub.10.1186/1475-2859-13-11 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002522366
    245 https://doi.org/10.1186/1475-2859-13-11
    246 rdf:type schema:CreativeWork
    247 sg:pub.10.1186/2191-0855-3-57 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038870321
    248 https://doi.org/10.1186/2191-0855-3-57
    249 rdf:type schema:CreativeWork
    250 sg:pub.10.1186/s12934-014-0108-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050038525
    251 https://doi.org/10.1186/s12934-014-0108-1
    252 rdf:type schema:CreativeWork
    253 sg:pub.10.1186/s12934-014-0119-y schema:sameAs https://app.dimensions.ai/details/publication/pub.1015332337
    254 https://doi.org/10.1186/s12934-014-0119-y
    255 rdf:type schema:CreativeWork
    256 sg:pub.10.1186/s12934-016-0527-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000414445
    257 https://doi.org/10.1186/s12934-016-0527-2
    258 rdf:type schema:CreativeWork
    259 sg:pub.10.1186/s13068-017-0809-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1085444236
    260 https://doi.org/10.1186/s13068-017-0809-x
    261 rdf:type schema:CreativeWork
    262 https://app.dimensions.ai/details/publication/pub.1075736259 schema:CreativeWork
    263 https://doi.org/10.1002/anie.201002060 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013746753
    264 rdf:type schema:CreativeWork
    265 https://doi.org/10.1002/bit.25914 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002798115
    266 rdf:type schema:CreativeWork
    267 https://doi.org/10.1002/bit.26081 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030892320
    268 rdf:type schema:CreativeWork
    269 https://doi.org/10.1002/bit.26446 schema:sameAs https://app.dimensions.ai/details/publication/pub.1091424822
    270 rdf:type schema:CreativeWork
    271 https://doi.org/10.1002/btpr.2485 schema:sameAs https://app.dimensions.ai/details/publication/pub.1085213499
    272 rdf:type schema:CreativeWork
    273 https://doi.org/10.1002/elsc.201300043 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041364918
    274 rdf:type schema:CreativeWork
    275 https://doi.org/10.1016/0922-338x(93)90067-i schema:sameAs https://app.dimensions.ai/details/publication/pub.1020703607
    276 rdf:type schema:CreativeWork
    277 https://doi.org/10.1016/j.biortech.2006.03.016 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002091828
    278 rdf:type schema:CreativeWork
    279 https://doi.org/10.1016/j.biortech.2012.11.141 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013582041
    280 rdf:type schema:CreativeWork
    281 https://doi.org/10.1016/j.enzmictec.2006.01.005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015566976
    282 rdf:type schema:CreativeWork
    283 https://doi.org/10.1016/j.fgb.2011.01.013 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047621184
    284 rdf:type schema:CreativeWork
    285 https://doi.org/10.1016/j.tim.2007.08.004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039219765
    286 rdf:type schema:CreativeWork
    287 https://doi.org/10.1016/j.ymben.2013.05.003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051320691
    288 rdf:type schema:CreativeWork
    289 https://doi.org/10.1016/j.ymben.2015.06.003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023776968
    290 rdf:type schema:CreativeWork
    291 https://doi.org/10.1016/j.ymben.2015.09.005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015624735
    292 rdf:type schema:CreativeWork
    293 https://doi.org/10.1016/j.ymben.2016.02.003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007407321
    294 rdf:type schema:CreativeWork
    295 https://doi.org/10.1016/j.ymben.2016.05.008 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002299708
    296 rdf:type schema:CreativeWork
    297 https://doi.org/10.1016/s0922-338x(97)89265-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044873486
    298 rdf:type schema:CreativeWork
    299 https://doi.org/10.1016/s0960-8524(02)00075-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025331186
    300 rdf:type schema:CreativeWork
    301 https://doi.org/10.1016/s1389-1723(02)80112-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003014735
    302 rdf:type schema:CreativeWork
    303 https://doi.org/10.1042/bj0331488 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039449255
    304 rdf:type schema:CreativeWork
    305 https://doi.org/10.1046/j.1365-2672.1999.00528.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1029938241
    306 rdf:type schema:CreativeWork
    307 https://doi.org/10.1080/07388551.2017.1312268 schema:sameAs https://app.dimensions.ai/details/publication/pub.1085242550
    308 rdf:type schema:CreativeWork
    309 https://doi.org/10.1099/00221287-137-3-533 schema:sameAs https://app.dimensions.ai/details/publication/pub.1060367948
    310 rdf:type schema:CreativeWork
    311 https://doi.org/10.1111/1751-7915.12329 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035093742
    312 rdf:type schema:CreativeWork
    313 https://doi.org/10.1111/lam.12810 schema:sameAs https://app.dimensions.ai/details/publication/pub.1092058775
    314 rdf:type schema:CreativeWork
    315 https://doi.org/10.1128/aem.03222-16 schema:sameAs https://app.dimensions.ai/details/publication/pub.1079392100
    316 rdf:type schema:CreativeWork
    317 https://doi.org/10.1128/aem.05763-11 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010190642
    318 rdf:type schema:CreativeWork
    319 https://doi.org/10.1128/jb.05465-11 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037349989
    320 rdf:type schema:CreativeWork
    321 https://doi.org/10.1139/m55-089 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039923383
    322 rdf:type schema:CreativeWork
    323 https://doi.org/10.1146/annurev-nutr-071714-034243 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021784640
    324 rdf:type schema:CreativeWork
    325 https://doi.org/10.1271/bbb1961.45.475 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024907795
    326 rdf:type schema:CreativeWork
    327 https://doi.org/10.19026/crjbs.7.5205 schema:sameAs https://app.dimensions.ai/details/publication/pub.1100934203
    328 rdf:type schema:CreativeWork
    329 https://doi.org/10.2323/jgam.60.191 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040889615
    330 rdf:type schema:CreativeWork
    331 https://doi.org/10.3389/fmicb.2013.00023 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022942643
    332 rdf:type schema:CreativeWork
    333 https://www.grid.ac/institutes/grid.258151.a schema:alternateName Jiangnan University
    334 schema:name The Key Laboratory of Carbohydrate Chemistry and Biotechnology, Ministry of Education, School of Biotechnology, Jiangnan University, 214122, Wuxi, China
    335 The Key Laboratory of Industrial Biotechnology, Ministry of Education, School of Biotechnology, Jiangnan University, 214122, Wuxi, China
    336 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...