Application of recombinant hemagglutinin proteins as alternative antigen standards for pandemic influenza vaccines View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2017-06-13

AUTHORS

Yejin Choi, Seong Yi Kwon, Ho Jung Oh, Sunbo Shim, Seokkee Chang, Hye Joo Chung, Do Keun Kim, Younsang Park, Younghee Lee

ABSTRACT

ObjectivesThe single radial immunodiffusion (SRID) assay, used to quantify hemagglutinin (HA) in influenza vaccines, requires reference reagents; however, because centralized production of reference reagents may slow the emergency deployment of vaccines, alternatives are needed.ResultsWe investigated the production of HA proteins using recombinant DNA technology, rather than a traditional egg-based production process. The HA proteins were then used in an SRID assay as a reference antigen. We found that HA can be quantified in both egg-based and cell-based influenza vaccines when recombinant HAs (rHAs) are used as the reference antigen. Furthermore, we confirmed that rHAs obtained from strains with pandemic potential, such as H5N1, H7N3, H7N9, and H9N2 strains, can be utilized in the SRID assay. The rHA production process takes just one month, in contrast to the traditional process that takes three to four months.ConclusionsThe use of rHAs may reduce the time required to produce reference reagents and facilitate timely introduction of vaccines during emergencies. More... »

PAGES

1375-1380

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s10529-017-2372-8

DOI

http://dx.doi.org/10.1007/s10529-017-2372-8

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1085995964

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/28612264


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