Antitumor activity of methylan polysaccharide derivatives View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2010-07

AUTHORS

Priyadharshini Ramachandran, Marimuthu Jeya, Hee-Jung Moon, Kyoung-Mi Lee, In-Won Kim, Jung-Hoe Kim, Jung-Kul Lee

ABSTRACT

Methylan polysaccharide derivatives were prepared by dialkylaminoalkylation and reductive amination followed by quaternization. Their antitumor activity was investigated and a relationship between structure and activity is suggested. For quaternized DEAE-methylan at only 75 mug ml(-1), tumor cell proliferation was suppressed by 58-84% in three cell lines tested in the order Colo < Hela < HepG2. More... »

PAGES

891-895

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s10529-010-0246-4

DOI

http://dx.doi.org/10.1007/s10529-010-0246-4

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1038784076

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/20349111


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