Fasting increases survival to cold in FOXO, DIF, autophagy mutants and in other genotypes of Drosophila melanogaster View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2015-08

AUTHORS

Éric Le Bourg, Isabelle Massou

ABSTRACT

Fasting increases survival to a severe cold stress in young and middle-aged wild-type flies, this effect being lowered or absent at old age. As an attempt to determine the mechanisms of this effect, genes involved in metabolism (dFOXO), autophagy (Atg7), innate immunity (Dif (1) ), and resistance to cold (Frost) were studied. The 12 mutant, RNAi and control lines tested in this study displayed an increased survival to cold after fasting. This shows that fasting has a robust effect on survival to cold in many genotypes, but the mechanism of this effect remains unknown. This mechanism does not seem to be linked to metabolic pathways often considered to play a critical role in ageing and longevity determinations (insulin/insulin-like growth factor-1 pathway and autophagy). More... »

PAGES

411-421

References to SciGraph publications

  • 2007-08. Hormetic effects of repeated exposures to cold at young age on longevity, aging and resistance to heat or cold shocks in Drosophila melanogaster in BIOGERONTOLOGY
  • 2011-06. Radiation hormesis and radioadaptive response in Drosophila melanogaster flies with different genetic backgrounds: the role of cellular stress-resistance mechanisms in BIOGERONTOLOGY
  • 1988-12. Protective effect of fasting upon cerebral hypoxic-ischemic injury in METABOLIC BRAIN DISEASE
  • 2011-07. Fasting vs dietary restriction in cellular protection and cancer treatment: from model organisms to patients in ONCOGENE
  • 2011-08. The NF-kB like factor DIF has weaker effects on Drosophila melanogaster immune defenses than previously thought in JOURNAL OF COMPARATIVE PHYSIOLOGY B
  • 1990-06. Fasting prior to transient cerebral ischemia reduces delayed neuronal necrosis in METABOLIC BRAIN DISEASE
  • 2012-06. Combined effects of two mild stresses (cold and hypergravity) on longevity, behavioral aging, and resistance to severe stresses in Drosophila melanogaster in BIOGERONTOLOGY
  • 2003-03. The Drosophila Forkhead transcription factor FOXO mediates the reduction in cell number associated with reduced insulin signaling in BMC BIOLOGY
  • 2012-08. The NF-κB-like factor DIF could explain some positive effects of a mild stress on longevity, behavioral aging, and resistance to strong stresses in Drosophila melanogaster in BIOGERONTOLOGY
  • 1976-04. Non-ageing developmental variant of Caenorhabditis elegans in NATURE
  • 2013-10. Fasting can protect young and middle-aged Drosophila melanogaster flies against a severe cold stress in BIOGERONTOLOGY
  • 2010-01. FOXO-dependent regulation of innate immune homeostasis in NATURE
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/s10522-015-9557-0

    DOI

    http://dx.doi.org/10.1007/s10522-015-9557-0

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1031219904

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/25663303


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