Decline in muscle strength and running endurance in klotho deficient C57BL/6 mice View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2013-12

AUTHORS

Michael Phelps, Christina Pettan-Brewer, Warren Ladiges, Zipora Yablonka-Reuveni

ABSTRACT

Alpha klotho (known as klotho) is a multifunctional protein that may be linked to age-associated decline in tissue homeostasis. The original klotho hypomorphic (klotho (hm) ) mouse, produced on a mixed C57BL/6 and C3H background, is short lived and exhibits extensive aging-like deterioration of several body systems. Differently, klotho (hm) mice on a pure C57BL/6 background do not appear sickly nor die young, which has permitted us to gain insight into the effect of klotho deficiency in adult life. First, analyzing klotho transcript levels in the kidney, the main site of klotho production, we demonstrated a 71-fold decline in klotho (hm) females compared to wildtype females versus only a 4-fold decline in mutant males. We then examined the effect of klotho deficiency on muscle-related attributes in adult mice, focusing on 7-11 month old females. Body weight and forelimb grip strength were significantly reduced in klotho (hm) mice compared to wildtype and klotho overexpressing mice. The female mice were also subjected to voluntary wheel running for a period of 6 days. Running endurance was markedly reduced in klotho (hm) mice, which exhibited a sporadic running pattern that may be characteristic of repeated bouts of exhaustions. When actually running, klotho (hm) females ran at the same speed as wildtype and klotho overexpressing mice, but spent about 65 % less time running compared to the other two groups. Our novel results suggest an important link between klotho deficiency and muscle performance. This study provides a foundation for further research on klotho involvement as a potential inhibitor of age-associated muscle deterioration. More... »

PAGES

729-739

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s10522-013-9447-2

DOI

http://dx.doi.org/10.1007/s10522-013-9447-2

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1033704193

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/24030242


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Clinical Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Body Weight", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Down-Regulation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Genotype", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Glucuronidase", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice, Inbred C3H", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice, Inbred C57BL", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Muscle Strength", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Muscle, Skeletal", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Phenotype", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Physical Endurance", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "RNA, Messenger", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Running", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Sex Factors", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "name": [
            "Department of Biological Structure, School of Medicine, University of Washington, Health Sciences Building, Room G520, 1959 NE Pacific Street, Box 35740, 98195, Seattle, WA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Phelps", 
        "givenName": "Michael", 
        "id": "sg:person.0726003134.55", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0726003134.55"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Washington", 
          "id": "https://www.grid.ac/institutes/grid.34477.33", 
          "name": [
            "Department of Comparative Medicine, School of Medicine, University of Washington, 98195, Seattle, WA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Pettan-Brewer", 
        "givenName": "Christina", 
        "id": "sg:person.01166715214.67", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01166715214.67"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Washington", 
          "id": "https://www.grid.ac/institutes/grid.34477.33", 
          "name": [
            "Department of Comparative Medicine, School of Medicine, University of Washington, 98195, Seattle, WA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ladiges", 
        "givenName": "Warren", 
        "id": "sg:person.014252073437.33", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014252073437.33"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Department of Biological Structure, School of Medicine, University of Washington, Health Sciences Building, Room G520, 1959 NE Pacific Street, Box 35740, 98195, Seattle, WA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Yablonka-Reuveni", 
        "givenName": "Zipora", 
        "id": "sg:person.01353366552.13", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01353366552.13"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1016/j.exger.2008.05.003", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001055325"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/jcp.1041330319", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002545705"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/36285", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002866404", 
          "https://doi.org/10.1038/36285"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.0709805104", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003002983"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.febslet.2009.09.009", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005432216"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature11438", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007059619", 
          "https://doi.org/10.1038/nature11438"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1681/asn.2012080865", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008705616"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1681/asn.2012080865", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008705616"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1634/stemcells.2006-0372", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009520894"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1359/jbmr.1997.12.12.2076", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011741845"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1369/0022155412452417", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012275399"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1369/0022155412452417", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012275399"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/01.mnh.0000232885.81142.83", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013210091"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/01.mnh.0000232885.81142.83", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013210091"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10522-013-9429-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014290034", 
          "https://doi.org/10.1007/s10522-013-9429-4"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10522-013-9429-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014290034", 
          "https://doi.org/10.1007/s10522-013-9429-4"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/978-1-4020-6768-6_6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014311151", 
          "https://doi.org/10.1007/978-1-4020-6768-6_6"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/978-1-4020-6768-6_6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014311151", 
          "https://doi.org/10.1007/978-1-4020-6768-6_6"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1440-1681.2007.04752.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014590322"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1440-1681.2007.04752.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014590322"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.numecd.2007.10.002", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014893290"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.1143578", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015340165"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.1112766", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016029340"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1369/0022155411426780", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016578469"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1369/0022155411426780", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016578469"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1165/ajrcmb.22.1.3554", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016712446"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/01.cir.0000124224.48962.32", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016834891"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1242/jcs.02602", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017517525"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.1144090", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017696289"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cell.2013.04.015", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018433496"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cger.2011.03.003", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019671533"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature07034", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019794166", 
          "https://doi.org/10.1038/nature07034"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10522-008-9131-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020187674", 
          "https://doi.org/10.1007/s10522-008-9131-0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10522-008-9131-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020187674", 
          "https://doi.org/10.1007/s10522-008-9131-0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/febs.12228", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022096389"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00421-011-2072-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022100054", 
          "https://doi.org/10.1007/s00421-011-2072-3"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1152/ajprenal.90538.2008", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022961950"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ydbio.2006.02.022", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023524193"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s11010-010-0642-z", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024099610", 
          "https://doi.org/10.1007/s11010-010-0642-z"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s11010-010-0642-z", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024099610", 
          "https://doi.org/10.1007/s11010-010-0642-z"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1152/japplphysiol.00380.2006", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025925553"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1006/bbrc.1998.8943", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026961587"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1681/asn.2013030294", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027122225"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1681/asn.2013030294", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027122225"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/bor.0b013e328358d59b", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027711425"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/bor.0b013e328358d59b", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027711425"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1096/fj.08-114397", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029276001"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pone.0013307", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029730795"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3402/pba.v1i0.7202", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031919984"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.yexcr.2010.05.035", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032136886"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1172/jci5705", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032887769"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.c700130200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034847240"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ydbio.2006.12.026", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038959793"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1046/j.1474-9728.2002.00017.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043881456"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature03260", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044062881", 
          "https://doi.org/10.1038/nature03260"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature03260", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044062881", 
          "https://doi.org/10.1038/nature03260"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.bbagen.2009.02.005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044097346"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.0913986107", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044454526"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m110.174037", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045720841"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10522-010-9297-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046453018", 
          "https://doi.org/10.1007/s10522-010-9297-0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1139/h10-067", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048224786"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jamda.2011.01.003", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048749221"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/gerona/57.11.b379", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050203769"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.0803223105", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051533990"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.mce.2008.10.052", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051733322"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10522-013-9428-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051842638", 
          "https://doi.org/10.1007/s10522-013-9428-5"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/emmm.200900045", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052130474"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/nar/gkp1005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052210249"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.febslet.2004.03.090", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053062075"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/geronj/30.3.257", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1059626125"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.318.5849.390b", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062596555"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/scitranslmed.3002227", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062687017"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1210/me.2010-0142", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064328523"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4161/cc.4.3.1518", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1072298226"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1079100105", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1152/ajpcell.1989.256.6.c1262", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1079293290"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/jn/127.5.990s", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1083094859"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2013-12", 
    "datePublishedReg": "2013-12-01", 
    "description": "Alpha klotho (known as klotho) is a multifunctional protein that may be linked to age-associated decline in tissue homeostasis. The original klotho hypomorphic (klotho (hm) ) mouse, produced on a mixed C57BL/6 and C3H background, is short lived and exhibits extensive aging-like deterioration of several body systems. Differently, klotho (hm) mice on a pure C57BL/6 background do not appear sickly nor die young, which has permitted us to gain insight into the effect of klotho deficiency in adult life. First, analyzing klotho transcript levels in the kidney, the main site of klotho production, we demonstrated a 71-fold decline in klotho (hm) females compared to wildtype females versus only a 4-fold decline in mutant males. We then examined the effect of klotho deficiency on muscle-related attributes in adult mice, focusing on 7-11\u00a0month old females. Body weight and forelimb grip strength were significantly reduced in klotho (hm) mice compared to wildtype and klotho overexpressing mice. The female mice were also subjected to voluntary wheel running for a period of 6\u00a0days. Running endurance was markedly reduced in klotho (hm) mice, which exhibited a sporadic running pattern that may be characteristic of repeated bouts of exhaustions. When actually running, klotho (hm) females ran at the same speed as wildtype and klotho overexpressing mice, but spent about 65\u00a0% less time running compared to the other two groups. Our novel results suggest an important link between klotho deficiency and muscle performance. This study provides a foundation for further research on klotho involvement as a potential inhibitor of age-associated muscle deterioration. ", 
    "genre": "research_article", 
    "id": "sg:pub.10.1007/s10522-013-9447-2", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.2447445", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2438606", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2681580", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1022481", 
        "issn": [
          "1389-5729", 
          "1573-6768"
        ], 
        "name": "Biogerontology", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "6", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "14"
      }
    ], 
    "name": "Decline in muscle strength and running endurance in klotho deficient C57BL/6 mice", 
    "pagination": "729-739", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "a08e505852486ab5a40220cc419f7d339af99cb5cec523e7f70f6e01268cca87"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "24030242"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "100930043"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s10522-013-9447-2"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1033704193"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s10522-013-9447-2", 
      "https://app.dimensions.ai/details/publication/pub.1033704193"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-10T19:09", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8678_00000514.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://link.springer.com/10.1007%2Fs10522-013-9447-2"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s10522-013-9447-2'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s10522-013-9447-2'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s10522-013-9447-2'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s10522-013-9447-2'


 

This table displays all metadata directly associated to this object as RDF triples.

373 TRIPLES      21 PREDICATES      111 URIs      38 LITERALS      26 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s10522-013-9447-2 schema:about N036e6906e96f4a898de9d9f9156536d1
2 N23badea6278842fbbc6c798fa68a9ea7
3 N2cc4a5f8cd7b42e4b75a7ca4b56f4854
4 N50dca1c4759141a7a719ae5e0cf79b33
5 N5e72e09ad1e14cb5bb398b910c69264d
6 N64e934a4633243aca529157f92287608
7 N659e174fd1714e4e9f931045a01d7b91
8 N7f962affc4324b40862c11426c4d63be
9 N80af6addd7614a7b9e2c49f1a3eb74fa
10 N837589d1b5fa4f9bb31fd4fc2e776f35
11 N8ec46ef6227c4e5386edb90bd2a69d0d
12 N93637797d86d433e840d4db0f658898f
13 Na78454cf28d14411bc3d0571a5320094
14 Nca308f4fbc9c43969c456d107dcee579
15 Nd9800d5050b34af9994466f8c5313fd7
16 Nedd0fc6174554c8fa8d6e11164af7e14
17 Nef014ef00fc348e8bba5df299a52b85c
18 anzsrc-for:11
19 anzsrc-for:1103
20 schema:author N354d1a769061401c818cb4f3d258f7fe
21 schema:citation sg:pub.10.1007/978-1-4020-6768-6_6
22 sg:pub.10.1007/s00421-011-2072-3
23 sg:pub.10.1007/s10522-008-9131-0
24 sg:pub.10.1007/s10522-010-9297-0
25 sg:pub.10.1007/s10522-013-9428-5
26 sg:pub.10.1007/s10522-013-9429-4
27 sg:pub.10.1007/s11010-010-0642-z
28 sg:pub.10.1038/36285
29 sg:pub.10.1038/nature03260
30 sg:pub.10.1038/nature07034
31 sg:pub.10.1038/nature11438
32 https://app.dimensions.ai/details/publication/pub.1079100105
33 https://doi.org/10.1002/emmm.200900045
34 https://doi.org/10.1002/jcp.1041330319
35 https://doi.org/10.1006/bbrc.1998.8943
36 https://doi.org/10.1016/j.bbagen.2009.02.005
37 https://doi.org/10.1016/j.cell.2013.04.015
38 https://doi.org/10.1016/j.cger.2011.03.003
39 https://doi.org/10.1016/j.exger.2008.05.003
40 https://doi.org/10.1016/j.febslet.2004.03.090
41 https://doi.org/10.1016/j.febslet.2009.09.009
42 https://doi.org/10.1016/j.jamda.2011.01.003
43 https://doi.org/10.1016/j.mce.2008.10.052
44 https://doi.org/10.1016/j.numecd.2007.10.002
45 https://doi.org/10.1016/j.ydbio.2006.02.022
46 https://doi.org/10.1016/j.ydbio.2006.12.026
47 https://doi.org/10.1016/j.yexcr.2010.05.035
48 https://doi.org/10.1046/j.1474-9728.2002.00017.x
49 https://doi.org/10.1073/pnas.0709805104
50 https://doi.org/10.1073/pnas.0803223105
51 https://doi.org/10.1073/pnas.0913986107
52 https://doi.org/10.1074/jbc.c700130200
53 https://doi.org/10.1074/jbc.m110.174037
54 https://doi.org/10.1093/gerona/57.11.b379
55 https://doi.org/10.1093/geronj/30.3.257
56 https://doi.org/10.1093/jn/127.5.990s
57 https://doi.org/10.1093/nar/gkp1005
58 https://doi.org/10.1096/fj.08-114397
59 https://doi.org/10.1097/01.mnh.0000232885.81142.83
60 https://doi.org/10.1097/bor.0b013e328358d59b
61 https://doi.org/10.1111/febs.12228
62 https://doi.org/10.1111/j.1440-1681.2007.04752.x
63 https://doi.org/10.1126/science.1112766
64 https://doi.org/10.1126/science.1143578
65 https://doi.org/10.1126/science.1144090
66 https://doi.org/10.1126/science.318.5849.390b
67 https://doi.org/10.1126/scitranslmed.3002227
68 https://doi.org/10.1139/h10-067
69 https://doi.org/10.1152/ajpcell.1989.256.6.c1262
70 https://doi.org/10.1152/ajprenal.90538.2008
71 https://doi.org/10.1152/japplphysiol.00380.2006
72 https://doi.org/10.1161/01.cir.0000124224.48962.32
73 https://doi.org/10.1165/ajrcmb.22.1.3554
74 https://doi.org/10.1172/jci5705
75 https://doi.org/10.1210/me.2010-0142
76 https://doi.org/10.1242/jcs.02602
77 https://doi.org/10.1359/jbmr.1997.12.12.2076
78 https://doi.org/10.1369/0022155411426780
79 https://doi.org/10.1369/0022155412452417
80 https://doi.org/10.1371/journal.pone.0013307
81 https://doi.org/10.1634/stemcells.2006-0372
82 https://doi.org/10.1681/asn.2012080865
83 https://doi.org/10.1681/asn.2013030294
84 https://doi.org/10.3402/pba.v1i0.7202
85 https://doi.org/10.4161/cc.4.3.1518
86 schema:datePublished 2013-12
87 schema:datePublishedReg 2013-12-01
88 schema:description Alpha klotho (known as klotho) is a multifunctional protein that may be linked to age-associated decline in tissue homeostasis. The original klotho hypomorphic (klotho (hm) ) mouse, produced on a mixed C57BL/6 and C3H background, is short lived and exhibits extensive aging-like deterioration of several body systems. Differently, klotho (hm) mice on a pure C57BL/6 background do not appear sickly nor die young, which has permitted us to gain insight into the effect of klotho deficiency in adult life. First, analyzing klotho transcript levels in the kidney, the main site of klotho production, we demonstrated a 71-fold decline in klotho (hm) females compared to wildtype females versus only a 4-fold decline in mutant males. We then examined the effect of klotho deficiency on muscle-related attributes in adult mice, focusing on 7-11 month old females. Body weight and forelimb grip strength were significantly reduced in klotho (hm) mice compared to wildtype and klotho overexpressing mice. The female mice were also subjected to voluntary wheel running for a period of 6 days. Running endurance was markedly reduced in klotho (hm) mice, which exhibited a sporadic running pattern that may be characteristic of repeated bouts of exhaustions. When actually running, klotho (hm) females ran at the same speed as wildtype and klotho overexpressing mice, but spent about 65 % less time running compared to the other two groups. Our novel results suggest an important link between klotho deficiency and muscle performance. This study provides a foundation for further research on klotho involvement as a potential inhibitor of age-associated muscle deterioration.
89 schema:genre research_article
90 schema:inLanguage en
91 schema:isAccessibleForFree true
92 schema:isPartOf N13e5b694213e4a1388a9b3d4e24d33e0
93 N2d34013fa144489aba9b1d694728481c
94 sg:journal.1022481
95 schema:name Decline in muscle strength and running endurance in klotho deficient C57BL/6 mice
96 schema:pagination 729-739
97 schema:productId N054fc10dc20a47b98ae21828875b021e
98 N267a6ed6258a44d2a6d885d920145d78
99 N43379a07bbb0402a8e8905989bdfd9ab
100 N5b302ff25c234794959f3792dd3f8f8c
101 N995c0a6b341b41f9b158fb5d270a3c3e
102 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033704193
103 https://doi.org/10.1007/s10522-013-9447-2
104 schema:sdDatePublished 2019-04-10T19:09
105 schema:sdLicense https://scigraph.springernature.com/explorer/license/
106 schema:sdPublisher Na935f021c59c4d0e88c6a15f5206847e
107 schema:url http://link.springer.com/10.1007%2Fs10522-013-9447-2
108 sgo:license sg:explorer/license/
109 sgo:sdDataset articles
110 rdf:type schema:ScholarlyArticle
111 N036e6906e96f4a898de9d9f9156536d1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
112 schema:name Phenotype
113 rdf:type schema:DefinedTerm
114 N054fc10dc20a47b98ae21828875b021e schema:name readcube_id
115 schema:value a08e505852486ab5a40220cc419f7d339af99cb5cec523e7f70f6e01268cca87
116 rdf:type schema:PropertyValue
117 N0ce630dc7bd840739c08134dbb627f83 rdf:first sg:person.01166715214.67
118 rdf:rest N9a1071633f0d4e06a287213c2ffe2053
119 N13e5b694213e4a1388a9b3d4e24d33e0 schema:volumeNumber 14
120 rdf:type schema:PublicationVolume
121 N23badea6278842fbbc6c798fa68a9ea7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
122 schema:name Mice, Inbred C3H
123 rdf:type schema:DefinedTerm
124 N267a6ed6258a44d2a6d885d920145d78 schema:name doi
125 schema:value 10.1007/s10522-013-9447-2
126 rdf:type schema:PropertyValue
127 N2cc4a5f8cd7b42e4b75a7ca4b56f4854 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
128 schema:name Running
129 rdf:type schema:DefinedTerm
130 N2d34013fa144489aba9b1d694728481c schema:issueNumber 6
131 rdf:type schema:PublicationIssue
132 N354d1a769061401c818cb4f3d258f7fe rdf:first sg:person.0726003134.55
133 rdf:rest N0ce630dc7bd840739c08134dbb627f83
134 N43379a07bbb0402a8e8905989bdfd9ab schema:name dimensions_id
135 schema:value pub.1033704193
136 rdf:type schema:PropertyValue
137 N50dca1c4759141a7a719ae5e0cf79b33 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
138 schema:name Mice, Inbred C57BL
139 rdf:type schema:DefinedTerm
140 N572bc92d0401453da00f01c6b434a993 schema:name Department of Biological Structure, School of Medicine, University of Washington, Health Sciences Building, Room G520, 1959 NE Pacific Street, Box 35740, 98195, Seattle, WA, USA
141 rdf:type schema:Organization
142 N5b302ff25c234794959f3792dd3f8f8c schema:name pubmed_id
143 schema:value 24030242
144 rdf:type schema:PropertyValue
145 N5e72e09ad1e14cb5bb398b910c69264d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
146 schema:name Mice
147 rdf:type schema:DefinedTerm
148 N64e934a4633243aca529157f92287608 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
149 schema:name Down-Regulation
150 rdf:type schema:DefinedTerm
151 N659e174fd1714e4e9f931045a01d7b91 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
152 schema:name Male
153 rdf:type schema:DefinedTerm
154 N798773ff73934e6cb6004cc647bcd30f schema:name Department of Biological Structure, School of Medicine, University of Washington, Health Sciences Building, Room G520, 1959 NE Pacific Street, Box 35740, 98195, Seattle, WA, USA
155 rdf:type schema:Organization
156 N7f962affc4324b40862c11426c4d63be schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
157 schema:name Body Weight
158 rdf:type schema:DefinedTerm
159 N80af6addd7614a7b9e2c49f1a3eb74fa schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
160 schema:name Genotype
161 rdf:type schema:DefinedTerm
162 N837589d1b5fa4f9bb31fd4fc2e776f35 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
163 schema:name Female
164 rdf:type schema:DefinedTerm
165 N8ec46ef6227c4e5386edb90bd2a69d0d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
166 schema:name Muscle Strength
167 rdf:type schema:DefinedTerm
168 N93637797d86d433e840d4db0f658898f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
169 schema:name Sex Factors
170 rdf:type schema:DefinedTerm
171 N995c0a6b341b41f9b158fb5d270a3c3e schema:name nlm_unique_id
172 schema:value 100930043
173 rdf:type schema:PropertyValue
174 N9a1071633f0d4e06a287213c2ffe2053 rdf:first sg:person.014252073437.33
175 rdf:rest Ndb71e506e70b4266974e5ed53f886ab7
176 Na78454cf28d14411bc3d0571a5320094 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
177 schema:name Physical Endurance
178 rdf:type schema:DefinedTerm
179 Na935f021c59c4d0e88c6a15f5206847e schema:name Springer Nature - SN SciGraph project
180 rdf:type schema:Organization
181 Nca308f4fbc9c43969c456d107dcee579 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
182 schema:name RNA, Messenger
183 rdf:type schema:DefinedTerm
184 Nd9800d5050b34af9994466f8c5313fd7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
185 schema:name Glucuronidase
186 rdf:type schema:DefinedTerm
187 Ndb71e506e70b4266974e5ed53f886ab7 rdf:first sg:person.01353366552.13
188 rdf:rest rdf:nil
189 Nedd0fc6174554c8fa8d6e11164af7e14 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
190 schema:name Muscle, Skeletal
191 rdf:type schema:DefinedTerm
192 Nef014ef00fc348e8bba5df299a52b85c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
193 schema:name Animals
194 rdf:type schema:DefinedTerm
195 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
196 schema:name Medical and Health Sciences
197 rdf:type schema:DefinedTerm
198 anzsrc-for:1103 schema:inDefinedTermSet anzsrc-for:
199 schema:name Clinical Sciences
200 rdf:type schema:DefinedTerm
201 sg:grant.2438606 http://pending.schema.org/fundedItem sg:pub.10.1007/s10522-013-9447-2
202 rdf:type schema:MonetaryGrant
203 sg:grant.2447445 http://pending.schema.org/fundedItem sg:pub.10.1007/s10522-013-9447-2
204 rdf:type schema:MonetaryGrant
205 sg:grant.2681580 http://pending.schema.org/fundedItem sg:pub.10.1007/s10522-013-9447-2
206 rdf:type schema:MonetaryGrant
207 sg:journal.1022481 schema:issn 1389-5729
208 1573-6768
209 schema:name Biogerontology
210 rdf:type schema:Periodical
211 sg:person.01166715214.67 schema:affiliation https://www.grid.ac/institutes/grid.34477.33
212 schema:familyName Pettan-Brewer
213 schema:givenName Christina
214 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01166715214.67
215 rdf:type schema:Person
216 sg:person.01353366552.13 schema:affiliation N572bc92d0401453da00f01c6b434a993
217 schema:familyName Yablonka-Reuveni
218 schema:givenName Zipora
219 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01353366552.13
220 rdf:type schema:Person
221 sg:person.014252073437.33 schema:affiliation https://www.grid.ac/institutes/grid.34477.33
222 schema:familyName Ladiges
223 schema:givenName Warren
224 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014252073437.33
225 rdf:type schema:Person
226 sg:person.0726003134.55 schema:affiliation N798773ff73934e6cb6004cc647bcd30f
227 schema:familyName Phelps
228 schema:givenName Michael
229 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0726003134.55
230 rdf:type schema:Person
231 sg:pub.10.1007/978-1-4020-6768-6_6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014311151
232 https://doi.org/10.1007/978-1-4020-6768-6_6
233 rdf:type schema:CreativeWork
234 sg:pub.10.1007/s00421-011-2072-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022100054
235 https://doi.org/10.1007/s00421-011-2072-3
236 rdf:type schema:CreativeWork
237 sg:pub.10.1007/s10522-008-9131-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020187674
238 https://doi.org/10.1007/s10522-008-9131-0
239 rdf:type schema:CreativeWork
240 sg:pub.10.1007/s10522-010-9297-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046453018
241 https://doi.org/10.1007/s10522-010-9297-0
242 rdf:type schema:CreativeWork
243 sg:pub.10.1007/s10522-013-9428-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051842638
244 https://doi.org/10.1007/s10522-013-9428-5
245 rdf:type schema:CreativeWork
246 sg:pub.10.1007/s10522-013-9429-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014290034
247 https://doi.org/10.1007/s10522-013-9429-4
248 rdf:type schema:CreativeWork
249 sg:pub.10.1007/s11010-010-0642-z schema:sameAs https://app.dimensions.ai/details/publication/pub.1024099610
250 https://doi.org/10.1007/s11010-010-0642-z
251 rdf:type schema:CreativeWork
252 sg:pub.10.1038/36285 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002866404
253 https://doi.org/10.1038/36285
254 rdf:type schema:CreativeWork
255 sg:pub.10.1038/nature03260 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044062881
256 https://doi.org/10.1038/nature03260
257 rdf:type schema:CreativeWork
258 sg:pub.10.1038/nature07034 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019794166
259 https://doi.org/10.1038/nature07034
260 rdf:type schema:CreativeWork
261 sg:pub.10.1038/nature11438 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007059619
262 https://doi.org/10.1038/nature11438
263 rdf:type schema:CreativeWork
264 https://app.dimensions.ai/details/publication/pub.1079100105 schema:CreativeWork
265 https://doi.org/10.1002/emmm.200900045 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052130474
266 rdf:type schema:CreativeWork
267 https://doi.org/10.1002/jcp.1041330319 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002545705
268 rdf:type schema:CreativeWork
269 https://doi.org/10.1006/bbrc.1998.8943 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026961587
270 rdf:type schema:CreativeWork
271 https://doi.org/10.1016/j.bbagen.2009.02.005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044097346
272 rdf:type schema:CreativeWork
273 https://doi.org/10.1016/j.cell.2013.04.015 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018433496
274 rdf:type schema:CreativeWork
275 https://doi.org/10.1016/j.cger.2011.03.003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019671533
276 rdf:type schema:CreativeWork
277 https://doi.org/10.1016/j.exger.2008.05.003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001055325
278 rdf:type schema:CreativeWork
279 https://doi.org/10.1016/j.febslet.2004.03.090 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053062075
280 rdf:type schema:CreativeWork
281 https://doi.org/10.1016/j.febslet.2009.09.009 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005432216
282 rdf:type schema:CreativeWork
283 https://doi.org/10.1016/j.jamda.2011.01.003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048749221
284 rdf:type schema:CreativeWork
285 https://doi.org/10.1016/j.mce.2008.10.052 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051733322
286 rdf:type schema:CreativeWork
287 https://doi.org/10.1016/j.numecd.2007.10.002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014893290
288 rdf:type schema:CreativeWork
289 https://doi.org/10.1016/j.ydbio.2006.02.022 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023524193
290 rdf:type schema:CreativeWork
291 https://doi.org/10.1016/j.ydbio.2006.12.026 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038959793
292 rdf:type schema:CreativeWork
293 https://doi.org/10.1016/j.yexcr.2010.05.035 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032136886
294 rdf:type schema:CreativeWork
295 https://doi.org/10.1046/j.1474-9728.2002.00017.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1043881456
296 rdf:type schema:CreativeWork
297 https://doi.org/10.1073/pnas.0709805104 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003002983
298 rdf:type schema:CreativeWork
299 https://doi.org/10.1073/pnas.0803223105 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051533990
300 rdf:type schema:CreativeWork
301 https://doi.org/10.1073/pnas.0913986107 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044454526
302 rdf:type schema:CreativeWork
303 https://doi.org/10.1074/jbc.c700130200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034847240
304 rdf:type schema:CreativeWork
305 https://doi.org/10.1074/jbc.m110.174037 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045720841
306 rdf:type schema:CreativeWork
307 https://doi.org/10.1093/gerona/57.11.b379 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050203769
308 rdf:type schema:CreativeWork
309 https://doi.org/10.1093/geronj/30.3.257 schema:sameAs https://app.dimensions.ai/details/publication/pub.1059626125
310 rdf:type schema:CreativeWork
311 https://doi.org/10.1093/jn/127.5.990s schema:sameAs https://app.dimensions.ai/details/publication/pub.1083094859
312 rdf:type schema:CreativeWork
313 https://doi.org/10.1093/nar/gkp1005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052210249
314 rdf:type schema:CreativeWork
315 https://doi.org/10.1096/fj.08-114397 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029276001
316 rdf:type schema:CreativeWork
317 https://doi.org/10.1097/01.mnh.0000232885.81142.83 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013210091
318 rdf:type schema:CreativeWork
319 https://doi.org/10.1097/bor.0b013e328358d59b schema:sameAs https://app.dimensions.ai/details/publication/pub.1027711425
320 rdf:type schema:CreativeWork
321 https://doi.org/10.1111/febs.12228 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022096389
322 rdf:type schema:CreativeWork
323 https://doi.org/10.1111/j.1440-1681.2007.04752.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1014590322
324 rdf:type schema:CreativeWork
325 https://doi.org/10.1126/science.1112766 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016029340
326 rdf:type schema:CreativeWork
327 https://doi.org/10.1126/science.1143578 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015340165
328 rdf:type schema:CreativeWork
329 https://doi.org/10.1126/science.1144090 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017696289
330 rdf:type schema:CreativeWork
331 https://doi.org/10.1126/science.318.5849.390b schema:sameAs https://app.dimensions.ai/details/publication/pub.1062596555
332 rdf:type schema:CreativeWork
333 https://doi.org/10.1126/scitranslmed.3002227 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062687017
334 rdf:type schema:CreativeWork
335 https://doi.org/10.1139/h10-067 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048224786
336 rdf:type schema:CreativeWork
337 https://doi.org/10.1152/ajpcell.1989.256.6.c1262 schema:sameAs https://app.dimensions.ai/details/publication/pub.1079293290
338 rdf:type schema:CreativeWork
339 https://doi.org/10.1152/ajprenal.90538.2008 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022961950
340 rdf:type schema:CreativeWork
341 https://doi.org/10.1152/japplphysiol.00380.2006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025925553
342 rdf:type schema:CreativeWork
343 https://doi.org/10.1161/01.cir.0000124224.48962.32 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016834891
344 rdf:type schema:CreativeWork
345 https://doi.org/10.1165/ajrcmb.22.1.3554 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016712446
346 rdf:type schema:CreativeWork
347 https://doi.org/10.1172/jci5705 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032887769
348 rdf:type schema:CreativeWork
349 https://doi.org/10.1210/me.2010-0142 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064328523
350 rdf:type schema:CreativeWork
351 https://doi.org/10.1242/jcs.02602 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017517525
352 rdf:type schema:CreativeWork
353 https://doi.org/10.1359/jbmr.1997.12.12.2076 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011741845
354 rdf:type schema:CreativeWork
355 https://doi.org/10.1369/0022155411426780 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016578469
356 rdf:type schema:CreativeWork
357 https://doi.org/10.1369/0022155412452417 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012275399
358 rdf:type schema:CreativeWork
359 https://doi.org/10.1371/journal.pone.0013307 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029730795
360 rdf:type schema:CreativeWork
361 https://doi.org/10.1634/stemcells.2006-0372 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009520894
362 rdf:type schema:CreativeWork
363 https://doi.org/10.1681/asn.2012080865 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008705616
364 rdf:type schema:CreativeWork
365 https://doi.org/10.1681/asn.2013030294 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027122225
366 rdf:type schema:CreativeWork
367 https://doi.org/10.3402/pba.v1i0.7202 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031919984
368 rdf:type schema:CreativeWork
369 https://doi.org/10.4161/cc.4.3.1518 schema:sameAs https://app.dimensions.ai/details/publication/pub.1072298226
370 rdf:type schema:CreativeWork
371 https://www.grid.ac/institutes/grid.34477.33 schema:alternateName University of Washington
372 schema:name Department of Comparative Medicine, School of Medicine, University of Washington, 98195, Seattle, WA, USA
373 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...