Effect of Oligochitosan on Experimental Venous Thrombosis in Guinea Pigs View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2021-11-18

AUTHORS

N. N. Drozd, A.V. Il’ina, B. Ts. Shagdarova, V. P. Varlamov

ABSTRACT

Oligochitosan Сh10/85 with a molecular weight of 10 kDa and a deacetylation degree of 85% prevented the development of experimental venous thrombosis in guinea pigs after intravenous administration in a dose of 30 mg/kg. In a concentration of 0.005-0.5 mg/ml, oligochitosan Ch10/85 did not provoke hemolysis of human red blood cells in in vitro experiments. The antithrombotic effect of oligochitosan Ch10/85 that exhibits low anticoagulant activity (by two orders of magnitude lower than that of unfractionated heparin) can be associated with inhibition of platelet aggregation. More... »

PAGES

33-37

References to SciGraph publications

  • 2016-09-10. Determination of residual protein and endotoxins in chitosan (review) in APPLIED BIOCHEMISTRY AND MICROBIOLOGY
  • 2017-08-14. Ristocetin-Induced Platelet Aggregation (RIPA) and RIPA Mixing Studies in HEMOSTASIS AND THROMBOSIS
  • 2014-07-03. Hydrolysis of chitozan with an enzyme complex from Myceliophthora sp. in APPLIED BIOCHEMISTRY AND MICROBIOLOGY
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/s10517-021-05325-x

    DOI

    http://dx.doi.org/10.1007/s10517-021-05325-x

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1142677814

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/34792720


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