Hemocompatibility of Silver Nanoparticles Based on Conjugate of Quaternized Chitosan with Gallic Acid in In Vitro Experiments View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2020-02

AUTHORS

N. N. Drozd, A. P. Lunkov, A. V. Il’ina, V. P. Varlamov

ABSTRACT

We studied hemocompatibility of silver nanoparticles synthesized on the basis of a conjugate of quaternized chitosan with gallic acid (QChit-Gal). For the three variants of silver particles (Nos. 1, 2, and 3), the QChit-Gal:AgNO3 ratio was 5:1, 5:3, and 1:1, respectively. Anticoagulant activity of all samples of silver nanoparticles was lower than that of the conjugate. Samples of nanoparticles Nos. 1 and 2 in a concentration of 0.0233 mg/ml did not affect plasma clotting time and can be used for intravenous administration. However, their concentration in the blood should not exceed 0.01 mg/ml, because in this concentration they do not affect erythrocyte membrane, do not induce platelet aggregation, and do not affect platelet aggregation induced by ADP. More... »

PAGES

507-511

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s10517-020-04742-8

DOI

http://dx.doi.org/10.1007/s10517-020-04742-8

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1125507755

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/32147767


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