Analysis of the Action of Quaternized Chitosans with Different Molecular Weight on Anticoagulant Activity of Heparins In Vitro View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2019-06-26

AUTHORS

N. N. Drozd, Yu. S. Logvinova, B. Ts. Shagdarova, A. V. Il’ina, V. P. Varlamov

ABSTRACT

Quaternized derivatives of chitosan with a substitution degree of 85-98% (highly substituted) synthesized from chitosans with a molecular weight of 5, 10, 20 kDa, with a degree of deacetylation of 89-98%, and the code numbers of QChit 5, QChit 10, QChit 20, respectively, completely neutralize antithrombin activity of unfractionated heparin and partially neutralize aXa activity of low-molecular-weight heparin (clexane), similar to protamine sulfate. The advantages of QChit 5 and QChit 10 over QChit 20 and protamine sulphate are the follows: the effect is achieved at lower concentrations and in greater concentration range; they do not promote platelet aggregation; in a concentration of 0.0072 mg/ml they do not destroy the erythrocyte membranes. More... »

PAGES

279-283

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s10517-019-04509-w

DOI

http://dx.doi.org/10.1007/s10517-019-04509-w

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1117497866

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/31243674


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