Induced Pluripotent Stem Cell-Derived Hematopoietic Embryoid Bodies Improve Mouse Status in Septic Peritonitis View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2019-03-22

AUTHORS

S. Kasuda, R. Kudo, K. Yuui, Y. Sakurai, K. Hatake

ABSTRACT

We examined the efficacy of embryoid bodies from 6-day induced pluripotent stem cells an in vivo sepsis model. Injection of embryoid bodies to septic mice improved the condition of their lungs and significantly increased their survival rate. Although embryoid bodies secretedsphingosine-1-phosphate in vitro, its serum levels in mouse plasma were significantly reduced compared to that in the control (untreated mice receiving PBS). Low concentrations of sphingosine-1-phosphate protected endothelial cells, while high concentrations disrupted endothelial barrier integrity. Therefore, exogenous sphingosine-1-phosphate secreted by embryoid bodies during early stage of sepsis might down regulate endogenous production of sphingosine-1-phosphate. Inhibition of excessive sphingosine-1-phosphate release protects against endothelial injury and suppresses a vicious cycle of inflammatory reactions. The obtained results open new prospects in induced pluripotent stem cells-based therapy for sepsis. More... »

PAGES

1-4

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s10517-019-04414-2

DOI

http://dx.doi.org/10.1007/s10517-019-04414-2

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1112945036

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/30903503


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1004", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical Biotechnology", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/10", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Technology", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Nara Medical University", 
          "id": "https://www.grid.ac/institutes/grid.410814.8", 
          "name": [
            "Department of Legal Medicine, Nara Medical University, Kashihara, Nara, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kasuda", 
        "givenName": "S.", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Nara Medical University", 
          "id": "https://www.grid.ac/institutes/grid.410814.8", 
          "name": [
            "Department of Legal Medicine, Nara Medical University, Kashihara, Nara, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kudo", 
        "givenName": "R.", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Nara Medical University", 
          "id": "https://www.grid.ac/institutes/grid.410814.8", 
          "name": [
            "Department of Legal Medicine, Nara Medical University, Kashihara, Nara, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Yuui", 
        "givenName": "K.", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Nara Medical University", 
          "id": "https://www.grid.ac/institutes/grid.410814.8", 
          "name": [
            "Department of Legal Medicine, Nara Medical University, Kashihara, Nara, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Sakurai", 
        "givenName": "Y.", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Nara Medical University", 
          "id": "https://www.grid.ac/institutes/grid.410814.8", 
          "name": [
            "Department of Legal Medicine, Nara Medical University, Kashihara, Nara, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hatake", 
        "givenName": "K.", 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1038/nature05934", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002347899", 
          "https://doi.org/10.1038/nature05934"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.hemonc.2016.04.002", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004110612"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/mbc.0b013e328344c63b", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008091363"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/mbc.0b013e328344c63b", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008091363"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1165/rcmb.2009-0223oc", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019861097"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0167-5273(95)02387-c", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020166609"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/emmm.201100145", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021635882"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1046/j.1365-2044.2001.01920.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023830900"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00281-011-0287-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025892816", 
          "https://doi.org/10.1007/s00281-011-0287-3"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1172/jci12450", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029964019"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nprot.2008.214", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036382062", 
          "https://doi.org/10.1038/nprot.2008.214"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ajpath.2010.09.041", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040328638"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1152/japplphysiol.00690.2002", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1063198833"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2174/138945007780362719", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1069180514"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10517-018-4078-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1103267878", 
          "https://doi.org/10.1007/s10517-018-4078-x"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10517-018-4078-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1103267878", 
          "https://doi.org/10.1007/s10517-018-4078-x"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2019-03-22", 
    "datePublishedReg": "2019-03-22", 
    "description": "We examined the efficacy of embryoid bodies from 6-day induced pluripotent stem cells an in vivo sepsis model. Injection of embryoid bodies to septic mice improved the condition of their lungs and significantly increased their survival rate. Although embryoid bodies secretedsphingosine-1-phosphate in vitro, its serum levels in mouse plasma were significantly reduced compared to that in the control (untreated mice receiving PBS). Low concentrations of sphingosine-1-phosphate protected endothelial cells, while high concentrations disrupted endothelial barrier integrity. Therefore, exogenous sphingosine-1-phosphate secreted by embryoid bodies during early stage of sepsis might down regulate endogenous production of sphingosine-1-phosphate. Inhibition of excessive sphingosine-1-phosphate release protects against endothelial injury and suppresses a vicious cycle of inflammatory reactions. The obtained results open new prospects in induced pluripotent stem cells-based therapy for sepsis.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1007/s10517-019-04414-2", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1017316", 
        "issn": [
          "0007-4888", 
          "1573-8221"
        ], 
        "name": "Bulletin of Experimental Biology and Medicine", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "5", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "166"
      }
    ], 
    "name": "Induced Pluripotent Stem Cell-Derived Hematopoietic Embryoid Bodies Improve Mouse Status in Septic Peritonitis", 
    "pagination": "1-4", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "6c491842b8024e6bb17260fddd7b6050db1103c76d995ade1ff0e0e4162bd875"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "30903503"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "0372557"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s10517-019-04414-2"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1112945036"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s10517-019-04414-2", 
      "https://app.dimensions.ai/details/publication/pub.1112945036"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T13:55", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000371_0000000371/records_130811_00000006.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://link.springer.com/10.1007%2Fs10517-019-04414-2"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s10517-019-04414-2'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s10517-019-04414-2'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s10517-019-04414-2'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s10517-019-04414-2'


 

This table displays all metadata directly associated to this object as RDF triples.

138 TRIPLES      21 PREDICATES      42 URIs      20 LITERALS      9 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s10517-019-04414-2 schema:about anzsrc-for:10
2 anzsrc-for:1004
3 schema:author N2e37e504a63b46a7b983110f804ddc41
4 schema:citation sg:pub.10.1007/s00281-011-0287-3
5 sg:pub.10.1007/s10517-018-4078-x
6 sg:pub.10.1038/nature05934
7 sg:pub.10.1038/nprot.2008.214
8 https://doi.org/10.1002/emmm.201100145
9 https://doi.org/10.1016/0167-5273(95)02387-c
10 https://doi.org/10.1016/j.ajpath.2010.09.041
11 https://doi.org/10.1016/j.hemonc.2016.04.002
12 https://doi.org/10.1046/j.1365-2044.2001.01920.x
13 https://doi.org/10.1097/mbc.0b013e328344c63b
14 https://doi.org/10.1152/japplphysiol.00690.2002
15 https://doi.org/10.1165/rcmb.2009-0223oc
16 https://doi.org/10.1172/jci12450
17 https://doi.org/10.2174/138945007780362719
18 schema:datePublished 2019-03-22
19 schema:datePublishedReg 2019-03-22
20 schema:description We examined the efficacy of embryoid bodies from 6-day induced pluripotent stem cells an in vivo sepsis model. Injection of embryoid bodies to septic mice improved the condition of their lungs and significantly increased their survival rate. Although embryoid bodies secretedsphingosine-1-phosphate in vitro, its serum levels in mouse plasma were significantly reduced compared to that in the control (untreated mice receiving PBS). Low concentrations of sphingosine-1-phosphate protected endothelial cells, while high concentrations disrupted endothelial barrier integrity. Therefore, exogenous sphingosine-1-phosphate secreted by embryoid bodies during early stage of sepsis might down regulate endogenous production of sphingosine-1-phosphate. Inhibition of excessive sphingosine-1-phosphate release protects against endothelial injury and suppresses a vicious cycle of inflammatory reactions. The obtained results open new prospects in induced pluripotent stem cells-based therapy for sepsis.
21 schema:genre research_article
22 schema:inLanguage en
23 schema:isAccessibleForFree false
24 schema:isPartOf N1c4e8cc4b63d47398744d4255b4d2139
25 Nc891b7984bc94efebbede360d33ea32e
26 sg:journal.1017316
27 schema:name Induced Pluripotent Stem Cell-Derived Hematopoietic Embryoid Bodies Improve Mouse Status in Septic Peritonitis
28 schema:pagination 1-4
29 schema:productId N53c5117db82b487a9c819d666e1253a5
30 N6b5a04c67b544df3969ceeedd6108d42
31 Na0946c72271842eda30eb7cbac971b78
32 Na5632b7e79f047ca97fc17b9a53adb84
33 Nc1b1261be83d406396d3dc2dff5858aa
34 schema:sameAs https://app.dimensions.ai/details/publication/pub.1112945036
35 https://doi.org/10.1007/s10517-019-04414-2
36 schema:sdDatePublished 2019-04-11T13:55
37 schema:sdLicense https://scigraph.springernature.com/explorer/license/
38 schema:sdPublisher N1978dd065ed648bc8c1a75a0f51290ba
39 schema:url https://link.springer.com/10.1007%2Fs10517-019-04414-2
40 sgo:license sg:explorer/license/
41 sgo:sdDataset articles
42 rdf:type schema:ScholarlyArticle
43 N1978dd065ed648bc8c1a75a0f51290ba schema:name Springer Nature - SN SciGraph project
44 rdf:type schema:Organization
45 N1c4e8cc4b63d47398744d4255b4d2139 schema:issueNumber 5
46 rdf:type schema:PublicationIssue
47 N215d9d638c3f41be8657b8d3d659abde rdf:first Nf69c6a96744d4e7784340c194fa83e31
48 rdf:rest N266bfa86c0e941ff87ba654db2b83951
49 N266bfa86c0e941ff87ba654db2b83951 rdf:first N43ac2cd781e446bda490c45c5ae67e2b
50 rdf:rest rdf:nil
51 N2e37e504a63b46a7b983110f804ddc41 rdf:first Nfc84f07ac31f45db9f4952dcc7795971
52 rdf:rest N6cec1a61fb24410ba650de0e52a08e9b
53 N39ac08dea9be4e27b82110c1c6e198e7 schema:affiliation https://www.grid.ac/institutes/grid.410814.8
54 schema:familyName Yuui
55 schema:givenName K.
56 rdf:type schema:Person
57 N43ac2cd781e446bda490c45c5ae67e2b schema:affiliation https://www.grid.ac/institutes/grid.410814.8
58 schema:familyName Hatake
59 schema:givenName K.
60 rdf:type schema:Person
61 N53c5117db82b487a9c819d666e1253a5 schema:name readcube_id
62 schema:value 6c491842b8024e6bb17260fddd7b6050db1103c76d995ade1ff0e0e4162bd875
63 rdf:type schema:PropertyValue
64 N6b5a04c67b544df3969ceeedd6108d42 schema:name pubmed_id
65 schema:value 30903503
66 rdf:type schema:PropertyValue
67 N6cec1a61fb24410ba650de0e52a08e9b rdf:first Nfbe7371a54934468814d309dce0df481
68 rdf:rest Ndeb6a1a8cc9a40c9aa0bcf3e08c50852
69 Na0946c72271842eda30eb7cbac971b78 schema:name nlm_unique_id
70 schema:value 0372557
71 rdf:type schema:PropertyValue
72 Na5632b7e79f047ca97fc17b9a53adb84 schema:name doi
73 schema:value 10.1007/s10517-019-04414-2
74 rdf:type schema:PropertyValue
75 Nc1b1261be83d406396d3dc2dff5858aa schema:name dimensions_id
76 schema:value pub.1112945036
77 rdf:type schema:PropertyValue
78 Nc891b7984bc94efebbede360d33ea32e schema:volumeNumber 166
79 rdf:type schema:PublicationVolume
80 Ndeb6a1a8cc9a40c9aa0bcf3e08c50852 rdf:first N39ac08dea9be4e27b82110c1c6e198e7
81 rdf:rest N215d9d638c3f41be8657b8d3d659abde
82 Nf69c6a96744d4e7784340c194fa83e31 schema:affiliation https://www.grid.ac/institutes/grid.410814.8
83 schema:familyName Sakurai
84 schema:givenName Y.
85 rdf:type schema:Person
86 Nfbe7371a54934468814d309dce0df481 schema:affiliation https://www.grid.ac/institutes/grid.410814.8
87 schema:familyName Kudo
88 schema:givenName R.
89 rdf:type schema:Person
90 Nfc84f07ac31f45db9f4952dcc7795971 schema:affiliation https://www.grid.ac/institutes/grid.410814.8
91 schema:familyName Kasuda
92 schema:givenName S.
93 rdf:type schema:Person
94 anzsrc-for:10 schema:inDefinedTermSet anzsrc-for:
95 schema:name Technology
96 rdf:type schema:DefinedTerm
97 anzsrc-for:1004 schema:inDefinedTermSet anzsrc-for:
98 schema:name Medical Biotechnology
99 rdf:type schema:DefinedTerm
100 sg:journal.1017316 schema:issn 0007-4888
101 1573-8221
102 schema:name Bulletin of Experimental Biology and Medicine
103 rdf:type schema:Periodical
104 sg:pub.10.1007/s00281-011-0287-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025892816
105 https://doi.org/10.1007/s00281-011-0287-3
106 rdf:type schema:CreativeWork
107 sg:pub.10.1007/s10517-018-4078-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1103267878
108 https://doi.org/10.1007/s10517-018-4078-x
109 rdf:type schema:CreativeWork
110 sg:pub.10.1038/nature05934 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002347899
111 https://doi.org/10.1038/nature05934
112 rdf:type schema:CreativeWork
113 sg:pub.10.1038/nprot.2008.214 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036382062
114 https://doi.org/10.1038/nprot.2008.214
115 rdf:type schema:CreativeWork
116 https://doi.org/10.1002/emmm.201100145 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021635882
117 rdf:type schema:CreativeWork
118 https://doi.org/10.1016/0167-5273(95)02387-c schema:sameAs https://app.dimensions.ai/details/publication/pub.1020166609
119 rdf:type schema:CreativeWork
120 https://doi.org/10.1016/j.ajpath.2010.09.041 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040328638
121 rdf:type schema:CreativeWork
122 https://doi.org/10.1016/j.hemonc.2016.04.002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004110612
123 rdf:type schema:CreativeWork
124 https://doi.org/10.1046/j.1365-2044.2001.01920.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1023830900
125 rdf:type schema:CreativeWork
126 https://doi.org/10.1097/mbc.0b013e328344c63b schema:sameAs https://app.dimensions.ai/details/publication/pub.1008091363
127 rdf:type schema:CreativeWork
128 https://doi.org/10.1152/japplphysiol.00690.2002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1063198833
129 rdf:type schema:CreativeWork
130 https://doi.org/10.1165/rcmb.2009-0223oc schema:sameAs https://app.dimensions.ai/details/publication/pub.1019861097
131 rdf:type schema:CreativeWork
132 https://doi.org/10.1172/jci12450 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029964019
133 rdf:type schema:CreativeWork
134 https://doi.org/10.2174/138945007780362719 schema:sameAs https://app.dimensions.ai/details/publication/pub.1069180514
135 rdf:type schema:CreativeWork
136 https://www.grid.ac/institutes/grid.410814.8 schema:alternateName Nara Medical University
137 schema:name Department of Legal Medicine, Nara Medical University, Kashihara, Nara, Japan
138 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...