Death Mechanisms of Pulmonary Alveolocytes in Mice Infected with Influenza Viruses A/H1N1/California/04/2009 and A/H5N1/Goose/Krasnoozerskoye/627/05 View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2019-03-22

AUTHORS

L. A. Cherdantseva, A. V. Kovner, T. V. Sharkova, V. A. Shkurupy, A. M. Shestopalov, O. V. Potapova

ABSTRACT

In CBA mice infected with influenza viruses A/H1N1/California/04/2009 and A/H5N1/Goose/Krasnoozerskoye/627/05 in a dose of 10 MLD50, the mechanisms of death of pulmonary alveolocytes over 10 postinfection days were studied by light microscopy, immunohistochemistry, and morphometry. In mice infected with A/H1N1, alveolocytes died predominantly via necrosis, while apoptosis mostly employed the mitochondrial pathway. In mice infected with A/H5N1, apoptosis was the dominant mechanism of alveolocyte death proceeded via membrane receptor signaling followed by switching to FAS-mediated pathway via activation of FADD, the apoptotic signal transduction protein. More... »

PAGES

1-4

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s10517-019-04408-0

DOI

http://dx.doi.org/10.1007/s10517-019-04408-0

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1112944655

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/30903504


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