Effect of 4-Methyl-Phenyl Biguanide on Free Radical Homeostasis and Activity of Oxidative Metabolism Enzymes in Rats with Cardiovascular Pathology Developing ... View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2019-03-22

AUTHORS

О. А. Safonova, T. N. Popova, T. N. Shestakova

ABSTRACT

We studied the effect of 4-methyl-phenyl biguanide, a substance chosen by PASS software (Prediction of Activity Spectra for Substance), on oxidative status and activity of oxidation metabolism enzymes participating in limitation free radical processes (aconitate hydratase, glucose-6-phosphate dehydrogenase, and NADP-isocitrate dehydrogenase) in the heart and blood serum of rats with cardiovascular pathology developing against the background of experimental rheumatoid arthritis. Activity of cardiomyocyte cytolysis markers in rat blood serum was also measured. Normalization of the studied parameters under the influence of the test compound in animals with experimental pathology attests to its positive effects on metabolic and free radical processes. More... »

PAGES

1-4

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s10517-019-04401-7

DOI

http://dx.doi.org/10.1007/s10517-019-04401-7

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1112943308

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/30903494


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Clinical Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Voronezh State University", 
          "id": "https://www.grid.ac/institutes/grid.20567.36", 
          "name": [
            "Department of Medical Biochemistry and Microbiology, Voronezh State University, Voronezh, Russia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Safonova", 
        "givenName": "\u041e. \u0410.", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Voronezh State University", 
          "id": "https://www.grid.ac/institutes/grid.20567.36", 
          "name": [
            "Department of Medical Biochemistry and Microbiology, Voronezh State University, Voronezh, Russia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Popova", 
        "givenName": "T. N.", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Voronezh State University", 
          "id": "https://www.grid.ac/institutes/grid.20567.36", 
          "name": [
            "Department of Medical Biochemistry and Microbiology, Voronezh State University, Voronezh, Russia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Shestakova", 
        "givenName": "T. N.", 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1007/s11094-015-1332-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000619261", 
          "https://doi.org/10.1007/s11094-015-1332-7"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s11883-008-0019-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001836103", 
          "https://doi.org/10.1007/s11883-008-0019-x"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1365-2249.2010.04293.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010600856"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3390/ijms15046002", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016227796"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s11094-013-0923-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025086562", 
          "https://doi.org/10.1007/s11094-013-0923-4"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1179/1351000213y.0000000073", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037048959"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10517-015-3089-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039243605", 
          "https://doi.org/10.1007/s10517-015-3089-0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3390/molecules180910378", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041971089"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3390/molecules180910378", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041971089"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1177/0960327109363973", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1063899772"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1177/0960327109363973", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1063899772"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4236/mri.2014.32006", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1072386975"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2019-03-22", 
    "datePublishedReg": "2019-03-22", 
    "description": "We studied the effect of 4-methyl-phenyl biguanide, a substance chosen by PASS software (Prediction of Activity Spectra for Substance), on oxidative status and activity of oxidation metabolism enzymes participating in limitation free radical processes (aconitate hydratase, glucose-6-phosphate dehydrogenase, and NADP-isocitrate dehydrogenase) in the heart and blood serum of rats with cardiovascular pathology developing against the background of experimental rheumatoid arthritis. Activity of cardiomyocyte cytolysis markers in rat blood serum was also measured. Normalization of the studied parameters under the influence of the test compound in animals with experimental pathology attests to its positive effects on metabolic and free radical processes.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1007/s10517-019-04401-7", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1017316", 
        "issn": [
          "0007-4888", 
          "1573-8221"
        ], 
        "name": "Bulletin of Experimental Biology and Medicine", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "5", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "166"
      }
    ], 
    "name": "Effect of 4-Methyl-Phenyl Biguanide on Free Radical Homeostasis and Activity of Oxidative Metabolism Enzymes in Rats with Cardiovascular Pathology Developing against the Background of Rheumatoid Arthritis", 
    "pagination": "1-4", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "394e503761c329cff7e574be1be0bedd043dbcbd275c4d9a1506aaca04c50e85"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "30903494"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "0372557"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s10517-019-04401-7"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1112943308"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s10517-019-04401-7", 
      "https://app.dimensions.ai/details/publication/pub.1112943308"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T14:01", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000371_0000000371/records_130829_00000006.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://link.springer.com/10.1007%2Fs10517-019-04401-7"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s10517-019-04401-7'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s10517-019-04401-7'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s10517-019-04401-7'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s10517-019-04401-7'


 

This table displays all metadata directly associated to this object as RDF triples.

114 TRIPLES      21 PREDICATES      38 URIs      20 LITERALS      9 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s10517-019-04401-7 schema:about anzsrc-for:11
2 anzsrc-for:1103
3 schema:author Nc098c71c4efc4a54aa666d7045581f24
4 schema:citation sg:pub.10.1007/s10517-015-3089-0
5 sg:pub.10.1007/s11094-013-0923-4
6 sg:pub.10.1007/s11094-015-1332-7
7 sg:pub.10.1007/s11883-008-0019-x
8 https://doi.org/10.1111/j.1365-2249.2010.04293.x
9 https://doi.org/10.1177/0960327109363973
10 https://doi.org/10.1179/1351000213y.0000000073
11 https://doi.org/10.3390/ijms15046002
12 https://doi.org/10.3390/molecules180910378
13 https://doi.org/10.4236/mri.2014.32006
14 schema:datePublished 2019-03-22
15 schema:datePublishedReg 2019-03-22
16 schema:description We studied the effect of 4-methyl-phenyl biguanide, a substance chosen by PASS software (Prediction of Activity Spectra for Substance), on oxidative status and activity of oxidation metabolism enzymes participating in limitation free radical processes (aconitate hydratase, glucose-6-phosphate dehydrogenase, and NADP-isocitrate dehydrogenase) in the heart and blood serum of rats with cardiovascular pathology developing against the background of experimental rheumatoid arthritis. Activity of cardiomyocyte cytolysis markers in rat blood serum was also measured. Normalization of the studied parameters under the influence of the test compound in animals with experimental pathology attests to its positive effects on metabolic and free radical processes.
17 schema:genre research_article
18 schema:inLanguage en
19 schema:isAccessibleForFree false
20 schema:isPartOf Nb90e6373cb1d47419215c51f343c7b4a
21 Neb32d555803640938d668c3e17ec99f8
22 sg:journal.1017316
23 schema:name Effect of 4-Methyl-Phenyl Biguanide on Free Radical Homeostasis and Activity of Oxidative Metabolism Enzymes in Rats with Cardiovascular Pathology Developing against the Background of Rheumatoid Arthritis
24 schema:pagination 1-4
25 schema:productId N2d8a4eb926154d419ef4534c71b46144
26 Nb86779446bc14ce1ab586f403582cba1
27 Nbf62cffc4ba8479aaf3a9e5e6b503a0b
28 Nc5d592cbe13747db8f856e673498e938
29 Ne5d8ea2af04a4f368ee09073a8e1d54f
30 schema:sameAs https://app.dimensions.ai/details/publication/pub.1112943308
31 https://doi.org/10.1007/s10517-019-04401-7
32 schema:sdDatePublished 2019-04-11T14:01
33 schema:sdLicense https://scigraph.springernature.com/explorer/license/
34 schema:sdPublisher N6454a2b360fe4297866eeecb9cd234ed
35 schema:url https://link.springer.com/10.1007%2Fs10517-019-04401-7
36 sgo:license sg:explorer/license/
37 sgo:sdDataset articles
38 rdf:type schema:ScholarlyArticle
39 N25f2383a654248ffb2b151bf275cd5a2 schema:affiliation https://www.grid.ac/institutes/grid.20567.36
40 schema:familyName Shestakova
41 schema:givenName T. N.
42 rdf:type schema:Person
43 N2d8a4eb926154d419ef4534c71b46144 schema:name dimensions_id
44 schema:value pub.1112943308
45 rdf:type schema:PropertyValue
46 N564a7e05be1d4d67ac9270fa2beddbfa schema:affiliation https://www.grid.ac/institutes/grid.20567.36
47 schema:familyName Popova
48 schema:givenName T. N.
49 rdf:type schema:Person
50 N6454a2b360fe4297866eeecb9cd234ed schema:name Springer Nature - SN SciGraph project
51 rdf:type schema:Organization
52 N7866045d342f41cbb81b1a55c0c0e625 rdf:first N25f2383a654248ffb2b151bf275cd5a2
53 rdf:rest rdf:nil
54 N935040f8c8cd45b7a9a2417ff815e44f schema:affiliation https://www.grid.ac/institutes/grid.20567.36
55 schema:familyName Safonova
56 schema:givenName О. А.
57 rdf:type schema:Person
58 Nb86779446bc14ce1ab586f403582cba1 schema:name pubmed_id
59 schema:value 30903494
60 rdf:type schema:PropertyValue
61 Nb90e6373cb1d47419215c51f343c7b4a schema:issueNumber 5
62 rdf:type schema:PublicationIssue
63 Nbf62cffc4ba8479aaf3a9e5e6b503a0b schema:name readcube_id
64 schema:value 394e503761c329cff7e574be1be0bedd043dbcbd275c4d9a1506aaca04c50e85
65 rdf:type schema:PropertyValue
66 Nbfd67050d14846d5b5a6b514aa490316 rdf:first N564a7e05be1d4d67ac9270fa2beddbfa
67 rdf:rest N7866045d342f41cbb81b1a55c0c0e625
68 Nc098c71c4efc4a54aa666d7045581f24 rdf:first N935040f8c8cd45b7a9a2417ff815e44f
69 rdf:rest Nbfd67050d14846d5b5a6b514aa490316
70 Nc5d592cbe13747db8f856e673498e938 schema:name doi
71 schema:value 10.1007/s10517-019-04401-7
72 rdf:type schema:PropertyValue
73 Ne5d8ea2af04a4f368ee09073a8e1d54f schema:name nlm_unique_id
74 schema:value 0372557
75 rdf:type schema:PropertyValue
76 Neb32d555803640938d668c3e17ec99f8 schema:volumeNumber 166
77 rdf:type schema:PublicationVolume
78 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
79 schema:name Medical and Health Sciences
80 rdf:type schema:DefinedTerm
81 anzsrc-for:1103 schema:inDefinedTermSet anzsrc-for:
82 schema:name Clinical Sciences
83 rdf:type schema:DefinedTerm
84 sg:journal.1017316 schema:issn 0007-4888
85 1573-8221
86 schema:name Bulletin of Experimental Biology and Medicine
87 rdf:type schema:Periodical
88 sg:pub.10.1007/s10517-015-3089-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039243605
89 https://doi.org/10.1007/s10517-015-3089-0
90 rdf:type schema:CreativeWork
91 sg:pub.10.1007/s11094-013-0923-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025086562
92 https://doi.org/10.1007/s11094-013-0923-4
93 rdf:type schema:CreativeWork
94 sg:pub.10.1007/s11094-015-1332-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000619261
95 https://doi.org/10.1007/s11094-015-1332-7
96 rdf:type schema:CreativeWork
97 sg:pub.10.1007/s11883-008-0019-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1001836103
98 https://doi.org/10.1007/s11883-008-0019-x
99 rdf:type schema:CreativeWork
100 https://doi.org/10.1111/j.1365-2249.2010.04293.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1010600856
101 rdf:type schema:CreativeWork
102 https://doi.org/10.1177/0960327109363973 schema:sameAs https://app.dimensions.ai/details/publication/pub.1063899772
103 rdf:type schema:CreativeWork
104 https://doi.org/10.1179/1351000213y.0000000073 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037048959
105 rdf:type schema:CreativeWork
106 https://doi.org/10.3390/ijms15046002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016227796
107 rdf:type schema:CreativeWork
108 https://doi.org/10.3390/molecules180910378 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041971089
109 rdf:type schema:CreativeWork
110 https://doi.org/10.4236/mri.2014.32006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1072386975
111 rdf:type schema:CreativeWork
112 https://www.grid.ac/institutes/grid.20567.36 schema:alternateName Voronezh State University
113 schema:name Department of Medical Biochemistry and Microbiology, Voronezh State University, Voronezh, Russia
114 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...