The Role of NO Synthase in the Cardioprotective Effect of Substances of Humic Origin on the Model of Ischemia and ... View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2019-03-23

AUTHORS

T. V. Lasukova, M. V. Zykova, M. V. Belousov, A. S. Gorbunov, L. A. Logvinova, A. M. Dygai

ABSTRACT

The cardioprotective and inotropic effects of standardized active natural substance based on high-molecular-weight compounds of humic origin were studied on the model of global ischemia (40 min) and reperfusion of isolated perfused rat heart. Preventive administration of the test substance (0.1 mg/ml) before ischemia/reperfusion modeling reduced reperfusion contracture and necrotic death of cardiomyocytes and promoted recovery of myocardial contractility. Blockade of NO synthase with L-NAME (100 μM) abolished the above effects of the test substance. It was hypothesized that NO synthase plays an important role in the development of the cardioprotective and inotropic effects of the test natural substance. More... »

PAGES

1-4

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s10517-019-04399-y

DOI

http://dx.doi.org/10.1007/s10517-019-04399-y

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1112942896

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/30903506


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