Neuroprotective Effects of Dibornol in Focal Cerebral Ischemia/Reperfusion in Rats View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2018-11-12

AUTHORS

G. A. Chenysheva, V. A. Smol’akova, A. V. Kutchin, I. Yu. Chukicheva, M. B. Plotnikov

ABSTRACT

Neuroprotective activity of 2,6-diisobornyl-4-methylphenol (Dibornol) was studied under conditions of experimental focal cerebral ischemia/reperfusion modeled by intraluminal occlusion of the left middle cerebral artery for 1 h followed by recirculation. Dibornol administered in a dose of 10 mg/kg intragastrically 24 h and 30 min before and 24 h after focal ischemia/reperfusion modeling reduced the size of the brain infarction zone by 52% (48 h after recirculation) and neurological deficit by 1.7-2.4 times in comparison with that in control animals. More... »

PAGES

1-4

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s10517-018-4278-4

DOI

http://dx.doi.org/10.1007/s10517-018-4278-4

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1109812635

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/30417302


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