Mitigating Effect of Nitrates (Monizol) on Pharmacodynamic Shifts in the Cardiovascular System Caused by Radioprotector Indralin View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2018-07

AUTHORS

M. V. Vasin, T. S. Gan’shina, R. S. Mirzoyan, L. A. Semenova, L. V. Koroleva, R. V. Afanas’ev, I. B. Ushakov

ABSTRACT

We studied the effect of radioprotector indralin (B-190) alone or in combination with monizol on BP and HR in rabbits, reduction of blood supply and spleen weight in rats and (CBA×C57Bl/6)F1 hybrids mice, and on blood loss from a wound on tip of the tail in mice. Being an α1-adrenomimetic, indralin caused hypertensive reaction with the development of bradycardia, reduced blood supply and spleen weight, and sharply reduced blood loss from the wound. Monizol as nitrate reduced BP without affecting HR and reduced blood loss from the wound. Monizol administered prior to indralin eliminated radioprotector-induced hypertensive reaction, reduced bradycardia by more than 2 times, and attenuated the effect of indralin on spleen weight and blood loss from the wound by 1.6-1.8 times. Monizol administered after indralin had no effect on shifts in peripheral blood supply caused by the radioprotector. More... »

PAGES

364-367

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s10517-018-4171-1

DOI

http://dx.doi.org/10.1007/s10517-018-4171-1

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1105569150

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/30006873


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