Dihydroquercetin and Fucoidin Inhibit the Increase of Angiotensin-Converting Enzyme Activity in the Rat Aorta after Irradiation View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2018-07

AUTHORS

A. F. Korystova, L. N. Kublik, Yu. A. Kim, M. Kh. Levitman, V. V. Shaposhnikova, Yu. N. Korystov

ABSTRACT

The time course of angiotensin-converting enzyme activity in the rat aorta after fractionated exposure to ionizing radiation and the effects of dihydroquercetin and fucoidin on this parameter were studied. Male Wistar rats were exposed to single or repeated (fractionated) X-ray radiation in a dose of 2.5 Gy at 200 kV. Activity of angiotensin-converting enzyme in aorta segments was evaluated 2 h after the last exposure by hydrolysis of hippuryl-histidineleucin substrate. Enzyme activity in the rat aorta was higher than normally after all the studied doses of fractionated exposure (2.5 Gy per fraction) with the maximum effect after the total dose of 7.5 Gy (3 fractions). Fucoidin, a blocker of endothelium receptors realizing the leukocyte adhesion to the endothelium, and flavonoid dihydroquercetin inhibiting expression of adhesion molecules in the endothelium abolished the increase in activity of angiotensinconverting enzyme in the rat aorta after single exposure; moreover, dihydroquercetin reduced significantly the effect of fractionated exposure. These data indicate that leukocyte adhesion to the endothelium is an important factor contributing to the increase of angiotensin-converting enzyme activity in the aorta. More... »

PAGES

360-363

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s10517-018-4170-2

DOI

http://dx.doi.org/10.1007/s10517-018-4170-2

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1105479743

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/30003420


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1117", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Public Health and Health Services", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Institute of Theoretical and Experimental Biophysics", 
          "id": "https://www.grid.ac/institutes/grid.419005.9", 
          "name": [
            "Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences, Pushchino, Moscow Region, Russia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Korystova", 
        "givenName": "A. F.", 
        "id": "sg:person.01204024721.74", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01204024721.74"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Institute of Theoretical and Experimental Biophysics", 
          "id": "https://www.grid.ac/institutes/grid.419005.9", 
          "name": [
            "Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences, Pushchino, Moscow Region, Russia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kublik", 
        "givenName": "L. N.", 
        "id": "sg:person.01305775335.99", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01305775335.99"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Institute of Cell Biophysics", 
          "id": "https://www.grid.ac/institutes/grid.418902.6", 
          "name": [
            "Institute of Cell Biophysics, Russian Academy of Sciences, Pushchino, Moscow Region, Russia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kim", 
        "givenName": "Yu. A.", 
        "id": "sg:person.01156221734.08", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01156221734.08"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Institute of Theoretical and Experimental Biophysics", 
          "id": "https://www.grid.ac/institutes/grid.419005.9", 
          "name": [
            "Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences, Pushchino, Moscow Region, Russia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Levitman", 
        "givenName": "M. Kh.", 
        "id": "sg:person.016433635467.69", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016433635467.69"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Institute of Theoretical and Experimental Biophysics", 
          "id": "https://www.grid.ac/institutes/grid.419005.9", 
          "name": [
            "Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences, Pushchino, Moscow Region, Russia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Shaposhnikova", 
        "givenName": "V. V.", 
        "id": "sg:person.01171546735.26", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01171546735.26"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Institute of Theoretical and Experimental Biophysics", 
          "id": "https://www.grid.ac/institutes/grid.419005.9", 
          "name": [
            "Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences, Pushchino, Moscow Region, Russia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Korystov", 
        "givenName": "Yu. N.", 
        "id": "sg:person.010310030074.45", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010310030074.45"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1007/s10517-016-3236-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007421849", 
          "https://doi.org/10.1007/s10517-016-3236-2"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/01.hyp.37.4.1047", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018462195"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/01.res.0000217340.40936.53", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029400601"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/01.res.0000217340.40936.53", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029400601"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1038/sj.bjp.0701836", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031673481"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1084/jem.185.6.1077", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052575852"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0008-6363(99)00091-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1054580396"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0008-6363(99)00169-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1054580474"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1074370563", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082406215", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082996261", 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10517-018-4133-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1104900987", 
          "https://doi.org/10.1007/s10517-018-4133-7"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2018-07", 
    "datePublishedReg": "2018-07-01", 
    "description": "The time course of angiotensin-converting enzyme activity in the rat aorta after fractionated exposure to ionizing radiation and the effects of dihydroquercetin and fucoidin on this parameter were studied. Male Wistar rats were exposed to single or repeated (fractionated) X-ray radiation in a dose of 2.5 Gy at 200 kV. Activity of angiotensin-converting enzyme in aorta segments was evaluated 2 h after the last exposure by hydrolysis of hippuryl-histidineleucin substrate. Enzyme activity in the rat aorta was higher than normally after all the studied doses of fractionated exposure (2.5 Gy per fraction) with the maximum effect after the total dose of 7.5 Gy (3 fractions). Fucoidin, a blocker of endothelium receptors realizing the leukocyte adhesion to the endothelium, and flavonoid dihydroquercetin inhibiting expression of adhesion molecules in the endothelium abolished the increase in activity of angiotensinconverting enzyme in the rat aorta after single exposure; moreover, dihydroquercetin reduced significantly the effect of fractionated exposure. These data indicate that leukocyte adhesion to the endothelium is an important factor contributing to the increase of angiotensin-converting enzyme activity in the aorta.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1007/s10517-018-4170-2", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1017316", 
        "issn": [
          "0007-4888", 
          "1573-8221"
        ], 
        "name": "Bulletin of Experimental Biology and Medicine", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "3", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "165"
      }
    ], 
    "name": "Dihydroquercetin and Fucoidin Inhibit the Increase of Angiotensin-Converting Enzyme Activity in the Rat Aorta after Irradiation", 
    "pagination": "360-363", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "679089295f40e17bf4184d7ad6f6f40d65ba858f57d81292b24a70ac3ece9ed3"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "30003420"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "0372557"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s10517-018-4170-2"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1105479743"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s10517-018-4170-2", 
      "https://app.dimensions.ai/details/publication/pub.1105479743"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T11:09", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000353_0000000353/records_45339_00000002.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://link.springer.com/10.1007%2Fs10517-018-4170-2"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s10517-018-4170-2'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s10517-018-4170-2'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s10517-018-4170-2'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s10517-018-4170-2'


 

This table displays all metadata directly associated to this object as RDF triples.

139 TRIPLES      21 PREDICATES      40 URIs      21 LITERALS      9 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s10517-018-4170-2 schema:about anzsrc-for:11
2 anzsrc-for:1117
3 schema:author N4fe05117df7545d485f9ae8f4e77eda2
4 schema:citation sg:pub.10.1007/s10517-016-3236-2
5 sg:pub.10.1007/s10517-018-4133-7
6 https://app.dimensions.ai/details/publication/pub.1074370563
7 https://app.dimensions.ai/details/publication/pub.1082406215
8 https://app.dimensions.ai/details/publication/pub.1082996261
9 https://doi.org/10.1016/s0008-6363(99)00091-7
10 https://doi.org/10.1016/s0008-6363(99)00169-8
11 https://doi.org/10.1038/sj.bjp.0701836
12 https://doi.org/10.1084/jem.185.6.1077
13 https://doi.org/10.1161/01.hyp.37.4.1047
14 https://doi.org/10.1161/01.res.0000217340.40936.53
15 schema:datePublished 2018-07
16 schema:datePublishedReg 2018-07-01
17 schema:description The time course of angiotensin-converting enzyme activity in the rat aorta after fractionated exposure to ionizing radiation and the effects of dihydroquercetin and fucoidin on this parameter were studied. Male Wistar rats were exposed to single or repeated (fractionated) X-ray radiation in a dose of 2.5 Gy at 200 kV. Activity of angiotensin-converting enzyme in aorta segments was evaluated 2 h after the last exposure by hydrolysis of hippuryl-histidineleucin substrate. Enzyme activity in the rat aorta was higher than normally after all the studied doses of fractionated exposure (2.5 Gy per fraction) with the maximum effect after the total dose of 7.5 Gy (3 fractions). Fucoidin, a blocker of endothelium receptors realizing the leukocyte adhesion to the endothelium, and flavonoid dihydroquercetin inhibiting expression of adhesion molecules in the endothelium abolished the increase in activity of angiotensinconverting enzyme in the rat aorta after single exposure; moreover, dihydroquercetin reduced significantly the effect of fractionated exposure. These data indicate that leukocyte adhesion to the endothelium is an important factor contributing to the increase of angiotensin-converting enzyme activity in the aorta.
18 schema:genre research_article
19 schema:inLanguage en
20 schema:isAccessibleForFree false
21 schema:isPartOf N02f5683c04eb425d9fcb7c700405812f
22 Nbdfc2aaaa12141e8a48e02062db47576
23 sg:journal.1017316
24 schema:name Dihydroquercetin and Fucoidin Inhibit the Increase of Angiotensin-Converting Enzyme Activity in the Rat Aorta after Irradiation
25 schema:pagination 360-363
26 schema:productId N23a1ab1117dd4a8694faad023a87b8c9
27 N52f122a4ff5043d3b32493ff4944307a
28 N5eb7a74bfa3f4dd69db08c792a4d7aa1
29 N70ae6ff7fb074351af003c1c678ef5f8
30 Nef0508d65dc14ee8b91b42143396805b
31 schema:sameAs https://app.dimensions.ai/details/publication/pub.1105479743
32 https://doi.org/10.1007/s10517-018-4170-2
33 schema:sdDatePublished 2019-04-11T11:09
34 schema:sdLicense https://scigraph.springernature.com/explorer/license/
35 schema:sdPublisher Nc85750e00896492eb6f35a8b7b7517a7
36 schema:url https://link.springer.com/10.1007%2Fs10517-018-4170-2
37 sgo:license sg:explorer/license/
38 sgo:sdDataset articles
39 rdf:type schema:ScholarlyArticle
40 N02f5683c04eb425d9fcb7c700405812f schema:volumeNumber 165
41 rdf:type schema:PublicationVolume
42 N23a1ab1117dd4a8694faad023a87b8c9 schema:name pubmed_id
43 schema:value 30003420
44 rdf:type schema:PropertyValue
45 N334e8d3e44304d27be67289031d8f409 rdf:first sg:person.01171546735.26
46 rdf:rest Nf2bf28ff19ba45d9b5cc9f35ad76cb13
47 N4fe05117df7545d485f9ae8f4e77eda2 rdf:first sg:person.01204024721.74
48 rdf:rest Nb05c53062729452caa5a5b767f8d2b2c
49 N52f122a4ff5043d3b32493ff4944307a schema:name nlm_unique_id
50 schema:value 0372557
51 rdf:type schema:PropertyValue
52 N5eb7a74bfa3f4dd69db08c792a4d7aa1 schema:name doi
53 schema:value 10.1007/s10517-018-4170-2
54 rdf:type schema:PropertyValue
55 N70ae6ff7fb074351af003c1c678ef5f8 schema:name dimensions_id
56 schema:value pub.1105479743
57 rdf:type schema:PropertyValue
58 Nb05c53062729452caa5a5b767f8d2b2c rdf:first sg:person.01305775335.99
59 rdf:rest Nd56f7ab2cb8b472281c3d3e8c1e62f14
60 Nbdfc2aaaa12141e8a48e02062db47576 schema:issueNumber 3
61 rdf:type schema:PublicationIssue
62 Nc85750e00896492eb6f35a8b7b7517a7 schema:name Springer Nature - SN SciGraph project
63 rdf:type schema:Organization
64 Nd56f7ab2cb8b472281c3d3e8c1e62f14 rdf:first sg:person.01156221734.08
65 rdf:rest Nea233b71456b4a80b73d8c273042a819
66 Nea233b71456b4a80b73d8c273042a819 rdf:first sg:person.016433635467.69
67 rdf:rest N334e8d3e44304d27be67289031d8f409
68 Nef0508d65dc14ee8b91b42143396805b schema:name readcube_id
69 schema:value 679089295f40e17bf4184d7ad6f6f40d65ba858f57d81292b24a70ac3ece9ed3
70 rdf:type schema:PropertyValue
71 Nf2bf28ff19ba45d9b5cc9f35ad76cb13 rdf:first sg:person.010310030074.45
72 rdf:rest rdf:nil
73 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
74 schema:name Medical and Health Sciences
75 rdf:type schema:DefinedTerm
76 anzsrc-for:1117 schema:inDefinedTermSet anzsrc-for:
77 schema:name Public Health and Health Services
78 rdf:type schema:DefinedTerm
79 sg:journal.1017316 schema:issn 0007-4888
80 1573-8221
81 schema:name Bulletin of Experimental Biology and Medicine
82 rdf:type schema:Periodical
83 sg:person.010310030074.45 schema:affiliation https://www.grid.ac/institutes/grid.419005.9
84 schema:familyName Korystov
85 schema:givenName Yu. N.
86 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010310030074.45
87 rdf:type schema:Person
88 sg:person.01156221734.08 schema:affiliation https://www.grid.ac/institutes/grid.418902.6
89 schema:familyName Kim
90 schema:givenName Yu. A.
91 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01156221734.08
92 rdf:type schema:Person
93 sg:person.01171546735.26 schema:affiliation https://www.grid.ac/institutes/grid.419005.9
94 schema:familyName Shaposhnikova
95 schema:givenName V. V.
96 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01171546735.26
97 rdf:type schema:Person
98 sg:person.01204024721.74 schema:affiliation https://www.grid.ac/institutes/grid.419005.9
99 schema:familyName Korystova
100 schema:givenName A. F.
101 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01204024721.74
102 rdf:type schema:Person
103 sg:person.01305775335.99 schema:affiliation https://www.grid.ac/institutes/grid.419005.9
104 schema:familyName Kublik
105 schema:givenName L. N.
106 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01305775335.99
107 rdf:type schema:Person
108 sg:person.016433635467.69 schema:affiliation https://www.grid.ac/institutes/grid.419005.9
109 schema:familyName Levitman
110 schema:givenName M. Kh.
111 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016433635467.69
112 rdf:type schema:Person
113 sg:pub.10.1007/s10517-016-3236-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007421849
114 https://doi.org/10.1007/s10517-016-3236-2
115 rdf:type schema:CreativeWork
116 sg:pub.10.1007/s10517-018-4133-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1104900987
117 https://doi.org/10.1007/s10517-018-4133-7
118 rdf:type schema:CreativeWork
119 https://app.dimensions.ai/details/publication/pub.1074370563 schema:CreativeWork
120 https://app.dimensions.ai/details/publication/pub.1082406215 schema:CreativeWork
121 https://app.dimensions.ai/details/publication/pub.1082996261 schema:CreativeWork
122 https://doi.org/10.1016/s0008-6363(99)00091-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1054580396
123 rdf:type schema:CreativeWork
124 https://doi.org/10.1016/s0008-6363(99)00169-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1054580474
125 rdf:type schema:CreativeWork
126 https://doi.org/10.1038/sj.bjp.0701836 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031673481
127 rdf:type schema:CreativeWork
128 https://doi.org/10.1084/jem.185.6.1077 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052575852
129 rdf:type schema:CreativeWork
130 https://doi.org/10.1161/01.hyp.37.4.1047 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018462195
131 rdf:type schema:CreativeWork
132 https://doi.org/10.1161/01.res.0000217340.40936.53 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029400601
133 rdf:type schema:CreativeWork
134 https://www.grid.ac/institutes/grid.418902.6 schema:alternateName Institute of Cell Biophysics
135 schema:name Institute of Cell Biophysics, Russian Academy of Sciences, Pushchino, Moscow Region, Russia
136 rdf:type schema:Organization
137 https://www.grid.ac/institutes/grid.419005.9 schema:alternateName Institute of Theoretical and Experimental Biophysics
138 schema:name Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences, Pushchino, Moscow Region, Russia
139 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...