Induced Pluripotent Stem Cell-Derived Hematopoietic Embryoid Bodies Secrete Sphingosine-1-Phosphate and Revert Endothelial Injury View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2018-04

AUTHORS

S. Kasuda, R. Kudo, K. Yuui, Y. Sakurai, K. Hatake

ABSTRACT

The possibility of sphingosine-1-phosphate production by induced pluripotent stem cells is examined to assess their potential in treatment of sepsis. The hematopoietic embryoid bodies were derived from the culture of 6-day-old differentiated induced pluripotent stem cells. These embryoid bodies secreted sphingosine-1-phosphate, an important bioactive lipid that regulates integrity of the pulmonary endothelial barrier, prevents elevation of its permeability, and impedes the formation of stress fibers in human endotheliocytes derived from umbilical vein. The data attest to potentiality of induced pluripotent stem cells in treatment of sepsis. More... »

PAGES

775-779

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s10517-018-4078-x

DOI

http://dx.doi.org/10.1007/s10517-018-4078-x

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1103267878

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/29658075


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