Ontology type: schema:ScholarlyArticle
2018-03
AUTHORSS. Ya. Zhanaeva, A. A. Rogozhnikova, E. L. Alperina, M. M. Gevorgyan, G. V. Idov
ABSTRACTWe studied activity of lysosomal cysteine proteases, cathepsins B and L, in brain structures (frontal cortex, caudate nucleus, hippocampus, and hypothalamus) of C57Bl/6J mice with aggressive and depressive-like behavior formed under conditions of chronic social stress (repeated experience of victories and defeats within 20 days). Mice with depressive-like behavior showed increased activity of cathepsin В in the hypothalamus and nucleus caudatus and increased activity of cathepsin L in the hippocampus compared to control animals not subjected to agonistic confrontations. In mice with aggressive behavior, protease activity in the studied brain structures was not changed. In 4 h after immune system activation with LPS (250 μg/kg), cathepsin L activity in the hippocampus of control mice increased in comparison with mice receiving saline. In contrast to control animals, LPS caused a decrease in activity of the enzyme in the caudate nucleus and frontal cortex of aggressive mice and in the hippocampus of mice with depressive-like behavior. More... »
PAGES425-429
http://scigraph.springernature.com/pub.10.1007/s10517-018-4004-2
DOIhttp://dx.doi.org/10.1007/s10517-018-4004-2
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PUBMEDhttps://www.ncbi.nlm.nih.gov/pubmed/29500808
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