Effects of Chitosan Derivative N-[(2-Hydroxy-3-Trimethylammonium)Propyl]Chloride on Anticoagulant Activity of Guinea Pig Plasma View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2017-07-26

AUTHORS

N. N. Drozd, B. Ts. Shagdarova, A. V. Il’ina, V. P. Varlamov

ABSTRACT

Intravenous injection of protamine sulfate or quarternized chitosan derivative to guinea pigs after injection of 70 aIIa U/kg non-fractionated heparin shortened plasma clotting time (shown by partial activated thromboplastin time, thrombin time, and prothrombin time). Intravenous injection of protamine sulfate or quarternized chitosan derivative to guinea pigs after injection of 1 mg/kg (100 aXa U/kg) low-molecular-weight heparin (clexane) led to shortening of plasma clotting time in the ReaClot Heparin test and to prolongation of plasma amidolytic activity in the factor Xa chromogenic substrate test. More... »

PAGES

340-343

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s10517-017-3799-6

DOI

http://dx.doi.org/10.1007/s10517-017-3799-6

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1090896731

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/28744652


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Anticoagulants", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Antidotes", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Chitosan", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Guinea Pigs", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Heparin", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Heparin, Low-Molecular-Weight", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Injections, Intravenous", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Partial Thromboplastin Time", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Protamines", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Prothrombin Time", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Quaternary Ammonium Compounds", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Thrombin Time", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "National Research Center for Hematology, Ministry of Health of the Russian Federation, Moscow, Russia", 
          "id": "http://www.grid.ac/institutes/grid.415738.c", 
          "name": [
            "National Research Center for Hematology, Ministry of Health of the Russian Federation, Moscow, Russia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Drozd", 
        "givenName": "N. N.", 
        "id": "sg:person.0677671407.10", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0677671407.10"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Institute of Bioengineering, Federal Research Centre \u201cFundamentals of Biotechnology\u201d, Russian Academy of Sciences, Moscow, Russia", 
          "id": "http://www.grid.ac/institutes/grid.4886.2", 
          "name": [
            "Institute of Bioengineering, Federal Research Centre \u201cFundamentals of Biotechnology\u201d, Russian Academy of Sciences, Moscow, Russia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Shagdarova", 
        "givenName": "B. Ts.", 
        "id": "sg:person.01256166763.35", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01256166763.35"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Institute of Bioengineering, Federal Research Centre \u201cFundamentals of Biotechnology\u201d, Russian Academy of Sciences, Moscow, Russia", 
          "id": "http://www.grid.ac/institutes/grid.4886.2", 
          "name": [
            "Institute of Bioengineering, Federal Research Centre \u201cFundamentals of Biotechnology\u201d, Russian Academy of Sciences, Moscow, Russia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Il\u2019ina", 
        "givenName": "A. V.", 
        "id": "sg:person.0762460543.01", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0762460543.01"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Institute of Bioengineering, Federal Research Centre \u201cFundamentals of Biotechnology\u201d, Russian Academy of Sciences, Moscow, Russia", 
          "id": "http://www.grid.ac/institutes/grid.4886.2", 
          "name": [
            "Institute of Bioengineering, Federal Research Centre \u201cFundamentals of Biotechnology\u201d, Russian Academy of Sciences, Moscow, Russia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Varlamov", 
        "givenName": "V. P.", 
        "id": "sg:person.0631556207.02", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0631556207.02"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1007/s11239-015-1315-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039668754", 
          "https://doi.org/10.1007/s11239-015-1315-2"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1134/s0003683816020149", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010065402", 
          "https://doi.org/10.1134/s0003683816020149"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s11239-015-1314-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048807509", 
          "https://doi.org/10.1007/s11239-015-1314-3"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s11239-013-0927-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039098067", 
          "https://doi.org/10.1007/s11239-013-0927-7"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nm.3102", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052218836", 
          "https://doi.org/10.1038/nm.3102"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2017-07-26", 
    "datePublishedReg": "2017-07-26", 
    "description": "Intravenous injection of protamine sulfate or quarternized chitosan derivative to guinea pigs after injection of 70 aIIa U/kg non-fractionated heparin shortened plasma clotting time (shown by partial activated thromboplastin time, thrombin time, and prothrombin time). Intravenous injection of protamine sulfate or quarternized chitosan derivative to guinea pigs after injection of 1 mg/kg (100 aXa U/kg) low-molecular-weight heparin (clexane) led to shortening of plasma clotting time in the ReaClot Heparin test and to prolongation of plasma amidolytic activity in the factor Xa chromogenic substrate test.", 
    "genre": "article", 
    "id": "sg:pub.10.1007/s10517-017-3799-6", 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1017316", 
        "issn": [
          "0007-4888", 
          "1573-8221"
        ], 
        "name": "Bulletin of Experimental Biology and Medicine", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "3", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "163"
      }
    ], 
    "keywords": [
      "intravenous injection", 
      "protamine sulfate", 
      "chromogenic substrate test", 
      "weight heparin", 
      "guinea pig plasma", 
      "anticoagulant activity", 
      "injection", 
      "heparin", 
      "amidolytic activity", 
      "pig plasma", 
      "pigs", 
      "prolongation", 
      "plasma", 
      "hydroxy-3", 
      "activity", 
      "test", 
      "shortening", 
      "substrate test", 
      "sulfate", 
      "time", 
      "effect", 
      "chitosan derivatives", 
      "derivatives N", 
      "derivatives"
    ], 
    "name": "Effects of Chitosan Derivative N-[(2-Hydroxy-3-Trimethylammonium)Propyl]Chloride on Anticoagulant Activity of Guinea Pig Plasma", 
    "pagination": "340-343", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1090896731"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s10517-017-3799-6"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "28744652"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s10517-017-3799-6", 
      "https://app.dimensions.ai/details/publication/pub.1090896731"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2022-12-01T06:35", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20221201/entities/gbq_results/article/article_728.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1007/s10517-017-3799-6"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s10517-017-3799-6'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s10517-017-3799-6'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s10517-017-3799-6'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s10517-017-3799-6'


 

This table displays all metadata directly associated to this object as RDF triples.

181 TRIPLES      21 PREDICATES      67 URIs      55 LITERALS      21 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s10517-017-3799-6 schema:about N062512a941bc45e9bfa92a4c46971ce9
2 N2a1bdfb3a91a4c419bee06a2c0fe2bc4
3 N3be3fefc9f404b8f99f121145a457889
4 N5a980e95ac524e639789a55b6014577f
5 N7d0a8c5cac754299a748e3ba90447edd
6 N8df27b3898da47ab8dab37bc4477dda9
7 N8f21b329dbe848c699bdfd1e189a2a50
8 N92c503d678ef42ce898c5dafa6e349b1
9 Nb777afc11db4420cb768579e26bac6ce
10 Nb7eee323e39b41b0819307a6c6c660ea
11 Nbba207ec9f5846b188723a765129b75c
12 Ncb043a92188f47d2b51687e965325a38
13 Nef7b0b6f7da54d63903ed55264944553
14 Nf1a86f35fcca4bd285a0e6e1e7a3081e
15 anzsrc-for:11
16 schema:author Nd237322a5f7f4727a9ae7c9405d0bc7f
17 schema:citation sg:pub.10.1007/s11239-013-0927-7
18 sg:pub.10.1007/s11239-015-1314-3
19 sg:pub.10.1007/s11239-015-1315-2
20 sg:pub.10.1038/nm.3102
21 sg:pub.10.1134/s0003683816020149
22 schema:datePublished 2017-07-26
23 schema:datePublishedReg 2017-07-26
24 schema:description Intravenous injection of protamine sulfate or quarternized chitosan derivative to guinea pigs after injection of 70 aIIa U/kg non-fractionated heparin shortened plasma clotting time (shown by partial activated thromboplastin time, thrombin time, and prothrombin time). Intravenous injection of protamine sulfate or quarternized chitosan derivative to guinea pigs after injection of 1 mg/kg (100 aXa U/kg) low-molecular-weight heparin (clexane) led to shortening of plasma clotting time in the ReaClot Heparin test and to prolongation of plasma amidolytic activity in the factor Xa chromogenic substrate test.
25 schema:genre article
26 schema:isAccessibleForFree false
27 schema:isPartOf N23bdc55ce8d949c483e9c993b9d75500
28 N7021cb2ff12949659f2f3304a5744f44
29 sg:journal.1017316
30 schema:keywords activity
31 amidolytic activity
32 anticoagulant activity
33 chitosan derivatives
34 chromogenic substrate test
35 derivatives
36 derivatives N
37 effect
38 guinea pig plasma
39 heparin
40 hydroxy-3
41 injection
42 intravenous injection
43 pig plasma
44 pigs
45 plasma
46 prolongation
47 protamine sulfate
48 shortening
49 substrate test
50 sulfate
51 test
52 time
53 weight heparin
54 schema:name Effects of Chitosan Derivative N-[(2-Hydroxy-3-Trimethylammonium)Propyl]Chloride on Anticoagulant Activity of Guinea Pig Plasma
55 schema:pagination 340-343
56 schema:productId N064d08eccfd443f3b830588a6b17b264
57 N9fea6d8a07824bc1a269219e84350e54
58 Nd78cf074a8f540d4b212ca393070a132
59 schema:sameAs https://app.dimensions.ai/details/publication/pub.1090896731
60 https://doi.org/10.1007/s10517-017-3799-6
61 schema:sdDatePublished 2022-12-01T06:35
62 schema:sdLicense https://scigraph.springernature.com/explorer/license/
63 schema:sdPublisher Nb86c133bad6442359bbf7f2ffe41da4f
64 schema:url https://doi.org/10.1007/s10517-017-3799-6
65 sgo:license sg:explorer/license/
66 sgo:sdDataset articles
67 rdf:type schema:ScholarlyArticle
68 N062512a941bc45e9bfa92a4c46971ce9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
69 schema:name Thrombin Time
70 rdf:type schema:DefinedTerm
71 N064d08eccfd443f3b830588a6b17b264 schema:name pubmed_id
72 schema:value 28744652
73 rdf:type schema:PropertyValue
74 N23bdc55ce8d949c483e9c993b9d75500 schema:volumeNumber 163
75 rdf:type schema:PublicationVolume
76 N2a1bdfb3a91a4c419bee06a2c0fe2bc4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
77 schema:name Animals
78 rdf:type schema:DefinedTerm
79 N3be3fefc9f404b8f99f121145a457889 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
80 schema:name Injections, Intravenous
81 rdf:type schema:DefinedTerm
82 N5a980e95ac524e639789a55b6014577f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
83 schema:name Prothrombin Time
84 rdf:type schema:DefinedTerm
85 N7021cb2ff12949659f2f3304a5744f44 schema:issueNumber 3
86 rdf:type schema:PublicationIssue
87 N7d0a8c5cac754299a748e3ba90447edd schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
88 schema:name Chitosan
89 rdf:type schema:DefinedTerm
90 N8df27b3898da47ab8dab37bc4477dda9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
91 schema:name Heparin
92 rdf:type schema:DefinedTerm
93 N8f21b329dbe848c699bdfd1e189a2a50 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
94 schema:name Partial Thromboplastin Time
95 rdf:type schema:DefinedTerm
96 N92c503d678ef42ce898c5dafa6e349b1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
97 schema:name Anticoagulants
98 rdf:type schema:DefinedTerm
99 N9fea6d8a07824bc1a269219e84350e54 schema:name doi
100 schema:value 10.1007/s10517-017-3799-6
101 rdf:type schema:PropertyValue
102 Na07732474d2a43f18ce0e4a691e413a9 rdf:first sg:person.01256166763.35
103 rdf:rest Nc13104c788384e8587976996f2ab4620
104 Nb777afc11db4420cb768579e26bac6ce schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
105 schema:name Quaternary Ammonium Compounds
106 rdf:type schema:DefinedTerm
107 Nb7eee323e39b41b0819307a6c6c660ea schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
108 schema:name Protamines
109 rdf:type schema:DefinedTerm
110 Nb86c133bad6442359bbf7f2ffe41da4f schema:name Springer Nature - SN SciGraph project
111 rdf:type schema:Organization
112 Nbba207ec9f5846b188723a765129b75c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
113 schema:name Antidotes
114 rdf:type schema:DefinedTerm
115 Nc13104c788384e8587976996f2ab4620 rdf:first sg:person.0762460543.01
116 rdf:rest Ne596b16c2946470d80733c5e3d95dece
117 Ncb043a92188f47d2b51687e965325a38 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
118 schema:name Heparin, Low-Molecular-Weight
119 rdf:type schema:DefinedTerm
120 Nd237322a5f7f4727a9ae7c9405d0bc7f rdf:first sg:person.0677671407.10
121 rdf:rest Na07732474d2a43f18ce0e4a691e413a9
122 Nd78cf074a8f540d4b212ca393070a132 schema:name dimensions_id
123 schema:value pub.1090896731
124 rdf:type schema:PropertyValue
125 Ne596b16c2946470d80733c5e3d95dece rdf:first sg:person.0631556207.02
126 rdf:rest rdf:nil
127 Nef7b0b6f7da54d63903ed55264944553 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
128 schema:name Female
129 rdf:type schema:DefinedTerm
130 Nf1a86f35fcca4bd285a0e6e1e7a3081e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
131 schema:name Guinea Pigs
132 rdf:type schema:DefinedTerm
133 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
134 schema:name Medical and Health Sciences
135 rdf:type schema:DefinedTerm
136 sg:journal.1017316 schema:issn 0007-4888
137 1573-8221
138 schema:name Bulletin of Experimental Biology and Medicine
139 schema:publisher Springer Nature
140 rdf:type schema:Periodical
141 sg:person.01256166763.35 schema:affiliation grid-institutes:grid.4886.2
142 schema:familyName Shagdarova
143 schema:givenName B. Ts.
144 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01256166763.35
145 rdf:type schema:Person
146 sg:person.0631556207.02 schema:affiliation grid-institutes:grid.4886.2
147 schema:familyName Varlamov
148 schema:givenName V. P.
149 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0631556207.02
150 rdf:type schema:Person
151 sg:person.0677671407.10 schema:affiliation grid-institutes:grid.415738.c
152 schema:familyName Drozd
153 schema:givenName N. N.
154 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0677671407.10
155 rdf:type schema:Person
156 sg:person.0762460543.01 schema:affiliation grid-institutes:grid.4886.2
157 schema:familyName Il’ina
158 schema:givenName A. V.
159 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0762460543.01
160 rdf:type schema:Person
161 sg:pub.10.1007/s11239-013-0927-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039098067
162 https://doi.org/10.1007/s11239-013-0927-7
163 rdf:type schema:CreativeWork
164 sg:pub.10.1007/s11239-015-1314-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048807509
165 https://doi.org/10.1007/s11239-015-1314-3
166 rdf:type schema:CreativeWork
167 sg:pub.10.1007/s11239-015-1315-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039668754
168 https://doi.org/10.1007/s11239-015-1315-2
169 rdf:type schema:CreativeWork
170 sg:pub.10.1038/nm.3102 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052218836
171 https://doi.org/10.1038/nm.3102
172 rdf:type schema:CreativeWork
173 sg:pub.10.1134/s0003683816020149 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010065402
174 https://doi.org/10.1134/s0003683816020149
175 rdf:type schema:CreativeWork
176 grid-institutes:grid.415738.c schema:alternateName National Research Center for Hematology, Ministry of Health of the Russian Federation, Moscow, Russia
177 schema:name National Research Center for Hematology, Ministry of Health of the Russian Federation, Moscow, Russia
178 rdf:type schema:Organization
179 grid-institutes:grid.4886.2 schema:alternateName Institute of Bioengineering, Federal Research Centre “Fundamentals of Biotechnology”, Russian Academy of Sciences, Moscow, Russia
180 schema:name Institute of Bioengineering, Federal Research Centre “Fundamentals of Biotechnology”, Russian Academy of Sciences, Moscow, Russia
181 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...