Effects of Chitosan Derivative N-[(2-Hydroxy-3-Trimethylammonium)Propyl]Chloride on Anticoagulant Activity of Guinea Pig Plasma View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2017-07-26

AUTHORS

N. N. Drozd, B. Ts. Shagdarova, A. V. Il’ina, V. P. Varlamov

ABSTRACT

Intravenous injection of protamine sulfate or quarternized chitosan derivative to guinea pigs after injection of 70 aIIa U/kg non-fractionated heparin shortened plasma clotting time (shown by partial activated thromboplastin time, thrombin time, and prothrombin time). Intravenous injection of protamine sulfate or quarternized chitosan derivative to guinea pigs after injection of 1 mg/kg (100 aXa U/kg) low-molecular-weight heparin (clexane) led to shortening of plasma clotting time in the ReaClot Heparin test and to prolongation of plasma amidolytic activity in the factor Xa chromogenic substrate test. More... »

PAGES

340-343

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s10517-017-3799-6

DOI

http://dx.doi.org/10.1007/s10517-017-3799-6

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1090896731

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/28744652


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