Frequency of 3’ VNTR Polymorphism in the Dopamine Transporter Gene SLC6A3 in Humans Predisposed to Antisocial Behavior View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2016-11

AUTHORS

E. V. Cherepkova, L. I. Aftanas, N. Maksimov, P. N. Menshanov

ABSTRACT

Predisposition to antisocial behavior can be related to the presence of certain polymorphic variants of genes encoding dopaminergic system proteins. We studied the frequencies of allele variants and genotypes of variable number tandem repeat polymorphism in 3' untranslated region (3' VTNR) of the dopaminergic transporter SLC6A3 gene in Caucasian men committed socially dangerous violent and non-violent crimes. Alleles with 9 and 10 repeats were most frequent in both the control group and group of men predisposed to antisocial behavior. At the same time, the 10/10 genotype was more frequently observed in the group of men prone to antisocial non-violent behavior. Hence, the presence of certain variants of 3' VTNR polymorphism of SLC6A3 gene in men is associated with predisposition to certain forms of antisocial behavior. More... »

PAGES

82-85

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s10517-016-3551-7

DOI

http://dx.doi.org/10.1007/s10517-016-3551-7

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1035123835

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/27882466


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