2-Morpholino-5-Phenyl-6H-1,3,4-Thiadiazine Corrects Metabolic Disorders during the Development of Alloxan Diabetes Mellitus in Rats View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2016-11

AUTHORS

V. V. Emelianov, E. A. Savateeva, L. P. Sidorova, T. A. Tseitler, I. F. Gette, T. S. Bulavintseva, S. E. Smirnykh, N. E. Maksimova, N. N. Mochulskaya, O. N. Chupakhin, V. A. Chereshnev

ABSTRACT

Metabolic disorders were evaluated in rats with alloxan diabetes mellitus after administration of 2-morpholino-5-phenyl-6H-1,3,4-thiadiazine (compound L-17). Administration of L-17 reduced the severity of metabolic disorders associated with diabetes mellitus. At the end of the experiment, the concentration of glucose, glycated hemoglobin, malonic dialdehyde, and catalase activity were significantly higher and peroxidase activity was significantly lower in the group of animals receiving L-17. The decrease of glycemia, glucose concentration, and glycated hemoglobin content was reached by the 3rd-4th week of the experiment. These data suggest that correction of biochemical parameters in rats with alloxan diabetes was reached after administration of L-17 for at least 3 weeks. More... »

PAGES

35-37

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s10517-016-3538-4

DOI

http://dx.doi.org/10.1007/s10517-016-3538-4

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1003227508

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/27878494


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