Stress of the Endoplasmic Reticulum of Neurons in Stroke Can Be Maximally Limited by Combined Exposure to Hypercapnia and Hypoxia View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2016-08

AUTHORS

P. P. Tregub, V. P. Kulikov, Yu. G. Motin, M. E. Nagibaeva, A. S. Zabrodina

ABSTRACT

We studied the expression of chaperone GRP-78 and transcription factor NF-kB during the development of ischemic tolerance of the brain after combined and isolated exposure to hypoxia and hypercapnia. Combined exposure to hypoxia and hypercapnia maximally increased the expression of chaperone GRP-78 and transcription factor NF-kB, while the formation of ischemia-induced tolerance under conditions of hypercapnic hypoxia can be associated with activation of adaptive stress mechanisms in the endoplasmic reticulum. Under these conditions, hypercapnia in combination with hypoxia is a priority factor for activation of GRP-78 and transcription factor NF-kB. More... »

PAGES

472-475

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s10517-016-3441-z

DOI

http://dx.doi.org/10.1007/s10517-016-3441-z

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1006320511

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/27591867


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