Depression of Macrophages Modifies Serum Lipid Profile in Hyperlipidemia View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2016-03

AUTHORS

N. V. Goncharova, A. B. Pupyshev, E. E. Filyushina, K. V. Loktev, E. Ts. Korolenko, E. L. Lushnikova, O. P. Molodykh, T. A. Korolenko, B. V. Churin

ABSTRACT

Suppression of functional activity of macrophages by gadolinium chloride, suppressing the macrophage population and the endocytosis velocity, was studied in vivo. Injection of GdCl3 led to an increase in serum cholesterol concentration. Preliminary injection of GdCl3 to mice with lipidemia 24 h before poloxamer 407 reduced the concentrations of triglycerides and LDL during marked depression of macrophages (in 24 h). Macrophage repopulation (days 5, 7) was associated with development of a trend to an increase of triglyceride and LDL levels. lectron microscopic study of Kupffer cells after injection of poloxamer 407 and its combination with gadoliniun chloride detected the intralysosomal accumulation syndrome in these cells (formation of auto- and heterophagolysosomes). Activity of cathepsin B, characteristic of macrophages, reduced 24 h after injections of GdCl3 and poloxamer 407 alone and restored in response to their combination. More... »

PAGES

617-621

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s10517-016-3231-7

DOI

http://dx.doi.org/10.1007/s10517-016-3231-7

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1023181737

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/27021105


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