Neuroprotective and Antiamnesic Effect of Erythropoietin Derivatives after Experimental Ischemic Injury of Cerebral Cortex View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2015-01-09

AUTHORS

G. A. Romanova, F. M. Shakova, I. V. Barskov, E. V. Stel’mashuk, E. E. Genrikhs, A. M. Cheremnykh, T. I. Kalinina, V. L. Yurin

ABSTRACT

Using the model of bilateral photothrombosis of the blood vessels in the prefrontal cortex we have shown that new hybrid proteins derived from recombinant human erythropoietin, carbamylated EPO-Fc and EPO-TR fusion proteins, injected intraperitoneally 1 h after ischemic injury contribute to restoration of passive avoidance response formed before photothrombotic injury and reduction in the volume of the ischemic focus. These data attest to nootropic and neuroprotective activities of these hybrid proteins. Carbamylated glycopeptide derivative ЕPO-TR exhibited prolonged neuroprotective properties. More... »

PAGES

318-321

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s10517-015-2751-x

DOI

http://dx.doi.org/10.1007/s10517-015-2751-x

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1005773064

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/25573359


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