Modulating Effect of Matrices with Calcium Phosphate Coating on Cytotoxicity of Strontium Ranelate and Ibandronic Acid In Vitro View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2014-06

AUTHORS

I. A. Khlusov, N. V. Ryazantseva, A. I. Vengerovskii, K. A. Nechaev, V. D. Yakushina, M. V. Dvornichenko, Yu. P. Sharkeev, E. V. Legostayeva, V. V. Novitskii

ABSTRACT

Strontium ranelate (29 μg/ml) and ibandronic acid (50 μM) produced a cytotoxic effect on rat bone marrow myelokaryocytes in vitro. Strontium ranelate increased the number of myelokaryocytes with signs of necrosis, ibandronic acid increased the number of apoptotic and necrotic cells in the 9-day 2D culture of bone marrow cells on the plastic surface of the wells of culture plates. Co-culturing of the bone marrow with 3D matrices with microarc calcium phosphate coating that simulated bone mineral matrix increased intracellular ROS concentration, but abolished the cytotoxic effect of these drugs. More... »

PAGES

215-219

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s10517-014-2528-7

DOI

http://dx.doi.org/10.1007/s10517-014-2528-7

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1006963218

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/24958373


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