Quantitative Morphochemical Characterization of the Neurons in Substantia Nigra of Rat Brain and Its Volume Reconstruction View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2014-04

AUTHORS

R. M. Khudoerkov, D. N. Voronkov, Yu. V. Dikalova

ABSTRACT

Three cell compartments differing by size and proportion of neurons were identified by 3D reconstruction of the substantia nigra pars compacta of the rat brain based on immunohistochemical localization of tyrosine hydroxylase, a marker of dopamine neurons. Dopaminepositive neurons prevailed over dopamine-free neurons (1.45:1) in the most voluminous (75%) dorsal part, and in smaller lateral and ventral parts, inverse cell ratios were observed: 0.54:1 and 0.78:1, respectively. Morphometry characterized the substantia nigra pars compacta as a structure consisting not only of several parts, but of horizons and showed differences between the neurons both in several parts and in several layers within the part. The revealed morphochemical heterogeneity of the substantia nigra pars compacta provides better understanding of the selective damage to its structures in Parkinson's disease. More... »

PAGES

861-864

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s10517-014-2470-8

DOI

http://dx.doi.org/10.1007/s10517-014-2470-8

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1003931072

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/24824717


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1109", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Neurosciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Analysis of Variance", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Dopaminergic Neurons", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Imaging, Three-Dimensional", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Immunohistochemistry", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Rats", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Rats, Wistar", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Substantia Nigra", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Tyrosine 3-Monooxygenase", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Department of Medical Sciences", 
          "id": "https://www.grid.ac/institutes/grid.466123.4", 
          "name": [
            "Neurology Research Center, Russian Academy of Medical Sciences, Moscow, Russia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Khudoerkov", 
        "givenName": "R. M.", 
        "id": "sg:person.071130541.25", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.071130541.25"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Medical Sciences", 
          "id": "https://www.grid.ac/institutes/grid.466123.4", 
          "name": [
            "Neurology Research Center, Russian Academy of Medical Sciences, Moscow, Russia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Voronkov", 
        "givenName": "D. N.", 
        "id": "sg:person.01324665446.15", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01324665446.15"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Medical Sciences", 
          "id": "https://www.grid.ac/institutes/grid.466123.4", 
          "name": [
            "Neurology Research Center, Russian Academy of Medical Sciences, Moscow, Russia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Dikalova", 
        "givenName": "Yu. V.", 
        "id": "sg:person.01314745770.15", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01314745770.15"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1016/j.neuroscience.2009.04.031", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000128046"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.neuroscience.2008.01.046", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003921438"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/(sici)1096-9861(20000522)421:1<107::aid-cne7>3.0.co;2-f", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019881531"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10517-010-0886-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032233210", 
          "https://doi.org/10.1007/s10517-010-0886-3"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10517-010-0886-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032233210", 
          "https://doi.org/10.1007/s10517-010-0886-3"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1354/vp.42-6-753", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042084202"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1354/vp.42-6-753", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042084202"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1354/vp.42-6-753", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042084202"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/brain/114.5.2283", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045332348"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/cne.902360404", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048555176"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00429-011-0349-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049845072", 
          "https://doi.org/10.1007/s00429-011-0349-2"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1078206253", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2014-04", 
    "datePublishedReg": "2014-04-01", 
    "description": "Three cell compartments differing by size and proportion of neurons were identified by 3D reconstruction of the substantia nigra pars compacta of the rat brain based on immunohistochemical localization of tyrosine hydroxylase, a marker of dopamine neurons. Dopaminepositive neurons prevailed over dopamine-free neurons (1.45:1) in the most voluminous (75%) dorsal part, and in smaller lateral and ventral parts, inverse cell ratios were observed: 0.54:1 and 0.78:1, respectively. Morphometry characterized the substantia nigra pars compacta as a structure consisting not only of several parts, but of horizons and showed differences between the neurons both in several parts and in several layers within the part. The revealed morphochemical heterogeneity of the substantia nigra pars compacta provides better understanding of the selective damage to its structures in Parkinson's disease.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1007/s10517-014-2470-8", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1017316", 
        "issn": [
          "0007-4888", 
          "1573-8221"
        ], 
        "name": "Bulletin of Experimental Biology and Medicine", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "6", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "156"
      }
    ], 
    "name": "Quantitative Morphochemical Characterization of the Neurons in Substantia Nigra of Rat Brain and Its Volume Reconstruction", 
    "pagination": "861-864", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "12bab076ddeecbcffdbe88416b76c8be0c87a64ce69a5b8ad9fbaaba8b3028cd"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "24824717"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "0372557"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s10517-014-2470-8"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1003931072"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s10517-014-2470-8", 
      "https://app.dimensions.ai/details/publication/pub.1003931072"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-10T21:31", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8687_00000485.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://link.springer.com/10.1007/s10517-014-2470-8"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s10517-014-2470-8'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s10517-014-2470-8'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s10517-014-2470-8'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s10517-014-2470-8'


 

This table displays all metadata directly associated to this object as RDF triples.

151 TRIPLES      21 PREDICATES      48 URIs      31 LITERALS      19 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s10517-014-2470-8 schema:about N052839c562e24ddbb146d149fc55558c
2 N2b22538c731d43cb8c0de6cdc492e4a1
3 N5c2105ff98774fbdb919924992b2e3f2
4 N5d713f167f1c4badaa3f475da55fdd9a
5 N6714684a7d7d408fbac87d9b0932cdda
6 N76852f5e9b244aa89eba66c74f46a7da
7 N889816f5c7e7471ea21b49e62ea36231
8 N97934ec574f54d0e91e86958ebdeedfb
9 Naf137b59d4b94e64aaf763b3c20835e3
10 Ne24b9367f56b46ba867de7146b11d625
11 anzsrc-for:11
12 anzsrc-for:1109
13 schema:author N685a5ef7ec7d44e0b5e549b712ee9991
14 schema:citation sg:pub.10.1007/s00429-011-0349-2
15 sg:pub.10.1007/s10517-010-0886-3
16 https://app.dimensions.ai/details/publication/pub.1078206253
17 https://doi.org/10.1002/(sici)1096-9861(20000522)421:1<107::aid-cne7>3.0.co;2-f
18 https://doi.org/10.1002/cne.902360404
19 https://doi.org/10.1016/j.neuroscience.2008.01.046
20 https://doi.org/10.1016/j.neuroscience.2009.04.031
21 https://doi.org/10.1093/brain/114.5.2283
22 https://doi.org/10.1354/vp.42-6-753
23 schema:datePublished 2014-04
24 schema:datePublishedReg 2014-04-01
25 schema:description Three cell compartments differing by size and proportion of neurons were identified by 3D reconstruction of the substantia nigra pars compacta of the rat brain based on immunohistochemical localization of tyrosine hydroxylase, a marker of dopamine neurons. Dopaminepositive neurons prevailed over dopamine-free neurons (1.45:1) in the most voluminous (75%) dorsal part, and in smaller lateral and ventral parts, inverse cell ratios were observed: 0.54:1 and 0.78:1, respectively. Morphometry characterized the substantia nigra pars compacta as a structure consisting not only of several parts, but of horizons and showed differences between the neurons both in several parts and in several layers within the part. The revealed morphochemical heterogeneity of the substantia nigra pars compacta provides better understanding of the selective damage to its structures in Parkinson's disease.
26 schema:genre research_article
27 schema:inLanguage en
28 schema:isAccessibleForFree false
29 schema:isPartOf N366142878fb54b2183478d1aef179cb8
30 N6060d677d03a4c9ebc7b5f918175f6ac
31 sg:journal.1017316
32 schema:name Quantitative Morphochemical Characterization of the Neurons in Substantia Nigra of Rat Brain and Its Volume Reconstruction
33 schema:pagination 861-864
34 schema:productId N2e55c7a7d3ee41019b70bcaad2c8ce9e
35 N4f63b043190f48be8c467a292ca607d8
36 N83c10c4e5efc4257a3cab3a144f1a279
37 N85546099178844db8f6f9c90a6c6a741
38 Ne26b6ab93b3044cc9323ccf85baaee4d
39 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003931072
40 https://doi.org/10.1007/s10517-014-2470-8
41 schema:sdDatePublished 2019-04-10T21:31
42 schema:sdLicense https://scigraph.springernature.com/explorer/license/
43 schema:sdPublisher Nee1491cc71c240e7b20112325ae200dd
44 schema:url http://link.springer.com/10.1007/s10517-014-2470-8
45 sgo:license sg:explorer/license/
46 sgo:sdDataset articles
47 rdf:type schema:ScholarlyArticle
48 N052839c562e24ddbb146d149fc55558c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
49 schema:name Analysis of Variance
50 rdf:type schema:DefinedTerm
51 N2b22538c731d43cb8c0de6cdc492e4a1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
52 schema:name Dopaminergic Neurons
53 rdf:type schema:DefinedTerm
54 N2e55c7a7d3ee41019b70bcaad2c8ce9e schema:name readcube_id
55 schema:value 12bab076ddeecbcffdbe88416b76c8be0c87a64ce69a5b8ad9fbaaba8b3028cd
56 rdf:type schema:PropertyValue
57 N366142878fb54b2183478d1aef179cb8 schema:volumeNumber 156
58 rdf:type schema:PublicationVolume
59 N4f63b043190f48be8c467a292ca607d8 schema:name nlm_unique_id
60 schema:value 0372557
61 rdf:type schema:PropertyValue
62 N59c6cc4650984578b3cfbdb1bf1307ef rdf:first sg:person.01324665446.15
63 rdf:rest N70e374f65ed4402ba5858627fd637283
64 N5c2105ff98774fbdb919924992b2e3f2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
65 schema:name Imaging, Three-Dimensional
66 rdf:type schema:DefinedTerm
67 N5d713f167f1c4badaa3f475da55fdd9a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
68 schema:name Substantia Nigra
69 rdf:type schema:DefinedTerm
70 N6060d677d03a4c9ebc7b5f918175f6ac schema:issueNumber 6
71 rdf:type schema:PublicationIssue
72 N6714684a7d7d408fbac87d9b0932cdda schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
73 schema:name Male
74 rdf:type schema:DefinedTerm
75 N685a5ef7ec7d44e0b5e549b712ee9991 rdf:first sg:person.071130541.25
76 rdf:rest N59c6cc4650984578b3cfbdb1bf1307ef
77 N70e374f65ed4402ba5858627fd637283 rdf:first sg:person.01314745770.15
78 rdf:rest rdf:nil
79 N76852f5e9b244aa89eba66c74f46a7da schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
80 schema:name Animals
81 rdf:type schema:DefinedTerm
82 N83c10c4e5efc4257a3cab3a144f1a279 schema:name pubmed_id
83 schema:value 24824717
84 rdf:type schema:PropertyValue
85 N85546099178844db8f6f9c90a6c6a741 schema:name doi
86 schema:value 10.1007/s10517-014-2470-8
87 rdf:type schema:PropertyValue
88 N889816f5c7e7471ea21b49e62ea36231 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
89 schema:name Immunohistochemistry
90 rdf:type schema:DefinedTerm
91 N97934ec574f54d0e91e86958ebdeedfb schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
92 schema:name Tyrosine 3-Monooxygenase
93 rdf:type schema:DefinedTerm
94 Naf137b59d4b94e64aaf763b3c20835e3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
95 schema:name Rats
96 rdf:type schema:DefinedTerm
97 Ne24b9367f56b46ba867de7146b11d625 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
98 schema:name Rats, Wistar
99 rdf:type schema:DefinedTerm
100 Ne26b6ab93b3044cc9323ccf85baaee4d schema:name dimensions_id
101 schema:value pub.1003931072
102 rdf:type schema:PropertyValue
103 Nee1491cc71c240e7b20112325ae200dd schema:name Springer Nature - SN SciGraph project
104 rdf:type schema:Organization
105 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
106 schema:name Medical and Health Sciences
107 rdf:type schema:DefinedTerm
108 anzsrc-for:1109 schema:inDefinedTermSet anzsrc-for:
109 schema:name Neurosciences
110 rdf:type schema:DefinedTerm
111 sg:journal.1017316 schema:issn 0007-4888
112 1573-8221
113 schema:name Bulletin of Experimental Biology and Medicine
114 rdf:type schema:Periodical
115 sg:person.01314745770.15 schema:affiliation https://www.grid.ac/institutes/grid.466123.4
116 schema:familyName Dikalova
117 schema:givenName Yu. V.
118 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01314745770.15
119 rdf:type schema:Person
120 sg:person.01324665446.15 schema:affiliation https://www.grid.ac/institutes/grid.466123.4
121 schema:familyName Voronkov
122 schema:givenName D. N.
123 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01324665446.15
124 rdf:type schema:Person
125 sg:person.071130541.25 schema:affiliation https://www.grid.ac/institutes/grid.466123.4
126 schema:familyName Khudoerkov
127 schema:givenName R. M.
128 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.071130541.25
129 rdf:type schema:Person
130 sg:pub.10.1007/s00429-011-0349-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049845072
131 https://doi.org/10.1007/s00429-011-0349-2
132 rdf:type schema:CreativeWork
133 sg:pub.10.1007/s10517-010-0886-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032233210
134 https://doi.org/10.1007/s10517-010-0886-3
135 rdf:type schema:CreativeWork
136 https://app.dimensions.ai/details/publication/pub.1078206253 schema:CreativeWork
137 https://doi.org/10.1002/(sici)1096-9861(20000522)421:1<107::aid-cne7>3.0.co;2-f schema:sameAs https://app.dimensions.ai/details/publication/pub.1019881531
138 rdf:type schema:CreativeWork
139 https://doi.org/10.1002/cne.902360404 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048555176
140 rdf:type schema:CreativeWork
141 https://doi.org/10.1016/j.neuroscience.2008.01.046 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003921438
142 rdf:type schema:CreativeWork
143 https://doi.org/10.1016/j.neuroscience.2009.04.031 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000128046
144 rdf:type schema:CreativeWork
145 https://doi.org/10.1093/brain/114.5.2283 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045332348
146 rdf:type schema:CreativeWork
147 https://doi.org/10.1354/vp.42-6-753 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042084202
148 rdf:type schema:CreativeWork
149 https://www.grid.ac/institutes/grid.466123.4 schema:alternateName Department of Medical Sciences
150 schema:name Neurology Research Center, Russian Academy of Medical Sciences, Moscow, Russia
151 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...