Phenotypic Differences between mdx Black Mice and mdx Albino Mice. Comparison of Cytokine Levels in the Blood View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2013-07

AUTHORS

M. A. Stenina, L. I. Krivov, D. A. Voevodin, V. N. Yarygin

ABSTRACT

In mdx mice, mutation in the muscle protein dystrophin gene results in the development of chronic degeneration of the muscle tissue. We performed a comparative analysis of blood cytokine levels in mdx mice, classical black mice and mice with additional genetic defect responsible for the manifestations of oculocutaneous albinism. In mdx albino mice, the total pool of cytokines (IL-10, IL-6, IL-5, IL-2, IL-1α, IL-4, IL-17, granulocyte-macrophage growth factor, TNF-α, and IFN-γ) was increased. This increase was not associated with selective release of one of the above cytokines into the blood. The fraction of pro-inflammatory cytokines (IL-6, IL-1α, TNF-α) was increased in the total pool and the percentage of antiinflammatory cytokines (IL-4) was reduced. Changes in cytokine pool probably reflect the differences in the severity of the pathological process in the muscle tissue of both genetic variations of mdx mice. More... »

PAGES

376-379

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s10517-013-2158-5

DOI

http://dx.doi.org/10.1007/s10517-013-2158-5

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1017649917

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/24137608


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0604", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Genetics", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biological Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Albinism, Oculocutaneous", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cytokines", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Flow Cytometry", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice, Inbred mdx", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Phenotype", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Pirogov Russian National Research Medical University", 
          "id": "https://www.grid.ac/institutes/grid.78028.35", 
          "name": [
            "N. I. Pirogov Russian National Research Medical University, Moscow, Russia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Stenina", 
        "givenName": "M. A.", 
        "id": "sg:person.01030653411.69", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01030653411.69"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Pirogov Russian National Research Medical University", 
          "id": "https://www.grid.ac/institutes/grid.78028.35", 
          "name": [
            "N. I. Pirogov Russian National Research Medical University, Moscow, Russia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Krivov", 
        "givenName": "L. I.", 
        "id": "sg:person.01076766611.34", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01076766611.34"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Pirogov Russian National Research Medical University", 
          "id": "https://www.grid.ac/institutes/grid.78028.35", 
          "name": [
            "N. I. Pirogov Russian National Research Medical University, Moscow, Russia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Voevodin", 
        "givenName": "D. A.", 
        "id": "sg:person.01077331727.21", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01077331727.21"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Pirogov Russian National Research Medical University", 
          "id": "https://www.grid.ac/institutes/grid.78028.35", 
          "name": [
            "N. I. Pirogov Russian National Research Medical University, Moscow, Russia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Yarygin", 
        "givenName": "V. N.", 
        "id": "sg:person.01207252213.99", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01207252213.99"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1073/pnas.81.4.1189", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001793181"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf01065627", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019488583", 
          "https://doi.org/10.1007/bf01065627"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10517-009-0564-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020662842", 
          "https://doi.org/10.1007/s10517-009-0564-5"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10517-009-0564-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020662842", 
          "https://doi.org/10.1007/s10517-009-0564-5"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10517-009-0564-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020662842", 
          "https://doi.org/10.1007/s10517-009-0564-5"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf01066339", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047249597", 
          "https://doi.org/10.1007/bf01066339"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1530/rep.1.00959", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049725644"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2013-07", 
    "datePublishedReg": "2013-07-01", 
    "description": "In mdx mice, mutation in the muscle protein dystrophin gene results in the development of chronic degeneration of the muscle tissue. We performed a comparative analysis of blood cytokine levels in mdx mice, classical black mice and mice with additional genetic defect responsible for the manifestations of oculocutaneous albinism. In mdx albino mice, the total pool of cytokines (IL-10, IL-6, IL-5, IL-2, IL-1\u03b1, IL-4, IL-17, granulocyte-macrophage growth factor, TNF-\u03b1, and IFN-\u03b3) was increased. This increase was not associated with selective release of one of the above cytokines into the blood. The fraction of pro-inflammatory cytokines (IL-6, IL-1\u03b1, TNF-\u03b1) was increased in the total pool and the percentage of antiinflammatory cytokines (IL-4) was reduced. Changes in cytokine pool probably reflect the differences in the severity of the pathological process in the muscle tissue of both genetic variations of mdx mice.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1007/s10517-013-2158-5", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1017316", 
        "issn": [
          "0007-4888", 
          "1573-8221"
        ], 
        "name": "Bulletin of Experimental Biology and Medicine", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "3", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "155"
      }
    ], 
    "name": "Phenotypic Differences between mdx Black Mice and mdx Albino Mice. Comparison of Cytokine Levels in the Blood", 
    "pagination": "376-379", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "5417b0e40772cb9fa9ddc58819370efc1c5fd457c9fba54421f7169fab430d38"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "24137608"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "0372557"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s10517-013-2158-5"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1017649917"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s10517-013-2158-5", 
      "https://app.dimensions.ai/details/publication/pub.1017649917"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-10T15:00", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8663_00000511.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://link.springer.com/10.1007%2Fs10517-013-2158-5"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s10517-013-2158-5'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s10517-013-2158-5'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s10517-013-2158-5'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s10517-013-2158-5'


 

This table displays all metadata directly associated to this object as RDF triples.

136 TRIPLES      21 PREDICATES      41 URIs      28 LITERALS      16 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s10517-013-2158-5 schema:about N0341365f10274a7fb1c422cdaa8ce0d9
2 N28b74cd53ce245c59ce6a3630e4e26e7
3 N755841798bf34a6b80c06e650eeeb6db
4 N7fed9a8fe460429d9a7fdbc6fbe1abef
5 N9250c633872f4aa2b2e229fbe8b50973
6 Nf14bc7f3da334f98b864c311e906400a
7 Nf8bc99baaf9b4bbab06b6d8adbfb4c1e
8 anzsrc-for:06
9 anzsrc-for:0604
10 schema:author Nf473e6aaf18d4f4ca70b2feb5aa69e6e
11 schema:citation sg:pub.10.1007/bf01065627
12 sg:pub.10.1007/bf01066339
13 sg:pub.10.1007/s10517-009-0564-5
14 https://doi.org/10.1073/pnas.81.4.1189
15 https://doi.org/10.1530/rep.1.00959
16 schema:datePublished 2013-07
17 schema:datePublishedReg 2013-07-01
18 schema:description In mdx mice, mutation in the muscle protein dystrophin gene results in the development of chronic degeneration of the muscle tissue. We performed a comparative analysis of blood cytokine levels in mdx mice, classical black mice and mice with additional genetic defect responsible for the manifestations of oculocutaneous albinism. In mdx albino mice, the total pool of cytokines (IL-10, IL-6, IL-5, IL-2, IL-1α, IL-4, IL-17, granulocyte-macrophage growth factor, TNF-α, and IFN-γ) was increased. This increase was not associated with selective release of one of the above cytokines into the blood. The fraction of pro-inflammatory cytokines (IL-6, IL-1α, TNF-α) was increased in the total pool and the percentage of antiinflammatory cytokines (IL-4) was reduced. Changes in cytokine pool probably reflect the differences in the severity of the pathological process in the muscle tissue of both genetic variations of mdx mice.
19 schema:genre research_article
20 schema:inLanguage en
21 schema:isAccessibleForFree false
22 schema:isPartOf N513769546c974a78a41fc4b4a1e65448
23 Ne312e34727c241158e7c52a26395c65b
24 sg:journal.1017316
25 schema:name Phenotypic Differences between mdx Black Mice and mdx Albino Mice. Comparison of Cytokine Levels in the Blood
26 schema:pagination 376-379
27 schema:productId N1fa78ede58af42b185aba12789ebbe1a
28 N61165bcb02b545f8828022d737f801a8
29 N95eb19d38f664f879651cb8ed3a7648b
30 Nd5ae56e0ae0d43398bc04fe3d11452f8
31 Nea449ad97016434cbf121c77a53c4a17
32 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017649917
33 https://doi.org/10.1007/s10517-013-2158-5
34 schema:sdDatePublished 2019-04-10T15:00
35 schema:sdLicense https://scigraph.springernature.com/explorer/license/
36 schema:sdPublisher Nda17ed9c42a044ed98a0baed172c6abe
37 schema:url http://link.springer.com/10.1007%2Fs10517-013-2158-5
38 sgo:license sg:explorer/license/
39 sgo:sdDataset articles
40 rdf:type schema:ScholarlyArticle
41 N0341365f10274a7fb1c422cdaa8ce0d9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
42 schema:name Cytokines
43 rdf:type schema:DefinedTerm
44 N1fa78ede58af42b185aba12789ebbe1a schema:name pubmed_id
45 schema:value 24137608
46 rdf:type schema:PropertyValue
47 N22b2ae6455794ce387a6982762eceb1e rdf:first sg:person.01077331727.21
48 rdf:rest Nada86d1b385c4cb4a6de3ea0c427a351
49 N28b74cd53ce245c59ce6a3630e4e26e7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
50 schema:name Phenotype
51 rdf:type schema:DefinedTerm
52 N513769546c974a78a41fc4b4a1e65448 schema:issueNumber 3
53 rdf:type schema:PublicationIssue
54 N61165bcb02b545f8828022d737f801a8 schema:name nlm_unique_id
55 schema:value 0372557
56 rdf:type schema:PropertyValue
57 N755841798bf34a6b80c06e650eeeb6db schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
58 schema:name Albinism, Oculocutaneous
59 rdf:type schema:DefinedTerm
60 N7da621a7cf7547ff9b5a534b6396859d rdf:first sg:person.01076766611.34
61 rdf:rest N22b2ae6455794ce387a6982762eceb1e
62 N7fed9a8fe460429d9a7fdbc6fbe1abef schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
63 schema:name Mice
64 rdf:type schema:DefinedTerm
65 N9250c633872f4aa2b2e229fbe8b50973 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
66 schema:name Flow Cytometry
67 rdf:type schema:DefinedTerm
68 N95eb19d38f664f879651cb8ed3a7648b schema:name dimensions_id
69 schema:value pub.1017649917
70 rdf:type schema:PropertyValue
71 Nada86d1b385c4cb4a6de3ea0c427a351 rdf:first sg:person.01207252213.99
72 rdf:rest rdf:nil
73 Nd5ae56e0ae0d43398bc04fe3d11452f8 schema:name doi
74 schema:value 10.1007/s10517-013-2158-5
75 rdf:type schema:PropertyValue
76 Nda17ed9c42a044ed98a0baed172c6abe schema:name Springer Nature - SN SciGraph project
77 rdf:type schema:Organization
78 Ne312e34727c241158e7c52a26395c65b schema:volumeNumber 155
79 rdf:type schema:PublicationVolume
80 Nea449ad97016434cbf121c77a53c4a17 schema:name readcube_id
81 schema:value 5417b0e40772cb9fa9ddc58819370efc1c5fd457c9fba54421f7169fab430d38
82 rdf:type schema:PropertyValue
83 Nf14bc7f3da334f98b864c311e906400a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
84 schema:name Mice, Inbred mdx
85 rdf:type schema:DefinedTerm
86 Nf473e6aaf18d4f4ca70b2feb5aa69e6e rdf:first sg:person.01030653411.69
87 rdf:rest N7da621a7cf7547ff9b5a534b6396859d
88 Nf8bc99baaf9b4bbab06b6d8adbfb4c1e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
89 schema:name Animals
90 rdf:type schema:DefinedTerm
91 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
92 schema:name Biological Sciences
93 rdf:type schema:DefinedTerm
94 anzsrc-for:0604 schema:inDefinedTermSet anzsrc-for:
95 schema:name Genetics
96 rdf:type schema:DefinedTerm
97 sg:journal.1017316 schema:issn 0007-4888
98 1573-8221
99 schema:name Bulletin of Experimental Biology and Medicine
100 rdf:type schema:Periodical
101 sg:person.01030653411.69 schema:affiliation https://www.grid.ac/institutes/grid.78028.35
102 schema:familyName Stenina
103 schema:givenName M. A.
104 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01030653411.69
105 rdf:type schema:Person
106 sg:person.01076766611.34 schema:affiliation https://www.grid.ac/institutes/grid.78028.35
107 schema:familyName Krivov
108 schema:givenName L. I.
109 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01076766611.34
110 rdf:type schema:Person
111 sg:person.01077331727.21 schema:affiliation https://www.grid.ac/institutes/grid.78028.35
112 schema:familyName Voevodin
113 schema:givenName D. A.
114 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01077331727.21
115 rdf:type schema:Person
116 sg:person.01207252213.99 schema:affiliation https://www.grid.ac/institutes/grid.78028.35
117 schema:familyName Yarygin
118 schema:givenName V. N.
119 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01207252213.99
120 rdf:type schema:Person
121 sg:pub.10.1007/bf01065627 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019488583
122 https://doi.org/10.1007/bf01065627
123 rdf:type schema:CreativeWork
124 sg:pub.10.1007/bf01066339 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047249597
125 https://doi.org/10.1007/bf01066339
126 rdf:type schema:CreativeWork
127 sg:pub.10.1007/s10517-009-0564-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020662842
128 https://doi.org/10.1007/s10517-009-0564-5
129 rdf:type schema:CreativeWork
130 https://doi.org/10.1073/pnas.81.4.1189 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001793181
131 rdf:type schema:CreativeWork
132 https://doi.org/10.1530/rep.1.00959 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049725644
133 rdf:type schema:CreativeWork
134 https://www.grid.ac/institutes/grid.78028.35 schema:alternateName Pirogov Russian National Research Medical University
135 schema:name N. I. Pirogov Russian National Research Medical University, Moscow, Russia
136 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...