Activity of Matrix Metalloproteinases during Antimycobacterial Therapy in Mice with Simulated Tuberculous Inflammation View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2013-05

AUTHORS

D. V. Sumenkova, G. S. Russkikh, O. N. Poteryaeva, L. M. Polyakov, L. E. Panin

ABSTRACT

Matrix metalloproteinases are shown to be involved in the pathogenesis of tuberculosis inflammation. In the early stages of BCG-granuloma formation in mouse liver and lungs, the serum levels of matrix metalloproteinases 2 and 7 increased by 4.5 times and remained unchanged while the pathology developed. Antimycobacterial therapy with isoniazid reduced enzyme activity almost to the level of intact control. The decrease in activity of matrix metalloproteinases 2 and 7 that play the most prominent role in the development of destructive forms of tuberculosis is of great therapeutic importance. More... »

PAGES

34-36

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s10517-013-2073-9

DOI

http://dx.doi.org/10.1007/s10517-013-2073-9

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1046259440

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/23667866


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