Experimental Study on the Efficacy of the Drug Brizantin in the Model of Nicotine Dependence View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2013-01

AUTHORS

I. A. Kheyfets, T. M. Vorob’eva, E. V. Veselovskaya, A. V. Shlyahova, N. A. Kirillova, S. P. Kolyadko, O. G. Berchenko, J. L. Dugina, O. I. Epstein

ABSTRACT

We estimated the efficacy of Brizantin preparation in suppressing nicotine dependence in rats. It was shown that nicotine-dependent rats in the situation of choice between the chamber with smoke or the chamber with food more frequently entered the chamber with tobacco smoke and stayed there longer. The rats that received Brizantin demonstrated significantly fewer visits to the chamber with smoke and spent there less time. Reduced locomotor activity and orientation and exploratory behavior in rats against the background of Brizantin administration also suggest reduced motivation for smoke inhalation. Thus, Brizantin effectively diminished nicotine dependence in rats in the model of nicotine addiction. More... »

PAGES

339-342

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s10517-013-1945-3

DOI

http://dx.doi.org/10.1007/s10517-013-1945-3

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1032377919

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/23484195


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