Cytokine profile of the blood in mice with normal and abnormal heart rhythm View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2012-04

AUTHORS

M. A. Stenina, L. I. Krivov, D. A. Voevodin, V. I. Savchuk, L. V. Kovalchuk, V. N. Yarygin

ABSTRACT

Differences in the pools of 10 cytokine were found in blood samples from the caudal vein of mice with normal and abnormal heart rhythm. Both groups were albino mice bred by us and differing from mdx albino mice by the absence of mutation in muscular dystrophin gene. Mice with normal heart rhythm had low IL-17 content and elevated concentrations of proinflammatory cytokines IL-6 and IL-1α in comparison with the normal (according to published data). In mice with bradyarrhythmias, increased blood levels of IL-10, IL-6, IL-5, IL-2, IL-1α, IL-17, IL-4, TNF-α, and granulocyte-macrophage colony-stimulating factor were detected. The relative content of IL-4 and IL-17 in the total cytokine pool increased. The lifespan of mice with bradyarrhythmias and cytokine hyperexpression was shorter by 2-3 months in comparison with mice without heart rhythm disturbances and moderate changes in the cytokine pool. More... »

PAGES

692-695

References to SciGraph publications

  • 2009-05. A New Genetic Variant of MDX Mice: Study of the Phenotype in BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE
  • 2009-05. Development of Amnesia in Different Mouse Strains in BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/s10517-012-1608-9

    DOI

    http://dx.doi.org/10.1007/s10517-012-1608-9

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1049712368

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/22803166


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