Expression of Molecular Markers in the Tumor and Survival Prognosis in Osteosarcoma View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2010-12

AUTHORS

I. V. Boulytcheva, Yu. N. Soloviev, N. E. Kushlinskii, A. N. Mahson

ABSTRACT

Immunohistochemical study of p53, VEGF, Flt-1/VEGFR1 Ab-1, EGFR, HER-2/neu, Bax, and Cox-2 expression in osteosarcomas was carried out in 40 patients aged 16-70 years. Expression of p53 was detected in 27.5% tumors, VEGF in 15%, Flt-1/VEGFR1 Ab-1 in 97.5%, EGFR in 52.5%, HER-2/neu in 32.5%, Bax in 77.8%, and Cox-2 in 32.3% tumors. Multifactorial analysis showed that the expression of HER-2/neu (p=0.004), p53 (p=0.01), and Cox-2 (p=0.04) in osteosarcomas significantly correlated with unfavorable prognosis for overall survival, while HER-2/neu (p=0.02) and Cox-2 (p=0.003) with relapse-free survival. Analysis of HER-2/neu, p53, and Cox-2 expression in the primary tumor should be taken into consideration in the treatment of patients with osteosarcoma. More... »

PAGES

237-242

References to SciGraph publications

  • 2008-02. Livin and Bcl-2 expression in high-grade osteosarcoma in JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
  • 2009-11. Cyclooxygenase-2 Overexpression Predicts Poor Survival in Patients with High-grade Extremity Osteosarcoma: A Pilot Study in CLINICAL ORTHOPAEDICS AND RELATED RESEARCH®
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/s10517-010-1114-x

    DOI

    http://dx.doi.org/10.1007/s10517-010-1114-x

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1024843927

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/21240382


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