Effects of Short-Term Exposure to Haloperidol and Reserpine on Dopamine Turnover in Nigrostriatal System in Rat Brain View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2010-12

AUTHORS

E. L. Dovedova, D. N. Voronkov, R. M. Khudoerkov

ABSTRACT

Spectrophotometric methods were employed to determine activity of dopamine metabolism enzymes, tyrosine hydroxylase and monoamine oxidase B, in nigrostriatal structures of the brain in Wistar rats after short-term (60 min) haloperidol or reserpine treatment. Activating effect of the test compounds on dopamine synthesis, more pronounced in the caudate nucleus, was demonstrated. Utilization of monoamine oxidase B transmitter was activated by haloperidol, but not reserpine. Some peculiarities of response of the nigrostriatal system structures to the test compounds were noted. We hypothesized the presence of a phase of dopamine metabolism activation, aimed at maintenance of dopamine transmission and nervous system adaptation at early terms after reserpine and haloperidol administration. More... »

PAGES

188-190

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s10517-010-1101-2

DOI

http://dx.doi.org/10.1007/s10517-010-1101-2

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1021093559

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/21240369


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