Effect of Plasma Lipoproteins and Their Complexes with Polysaccharides on Interleukin-1β Concentration in Macrophages of Mice with HA-1 Ascitic Hepatoma View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2009-04

AUTHORS

L. M. Polyakov, D. V. Sumenkova, L. E. Panin

ABSTRACT

Experiments on cultured peritoneal macrophage from mice with HA-1 ascitic hepatoma showed that plasma lipoproteins present in the incubation medium decreased intracellular concentration of interleukin-1beta. These changes were most pronounced for high-density lipoproteins (alone or in combination with cortisol). Bacterial and yeast polysaccharides had little effect on interleukin-1beta concentration in macrophages. Addition of polysaccharides in combination with lipoproteins was followed by a 2-3-fold decrease in interleukin-1beta concentration. A combination of polysaccharides and high-density lipoproteins had the strongest effect. These properties of plasma lipoproteins should be taken into account in the correction of macrophage function during tumor growth. More... »

PAGES

466

References to SciGraph publications

  • 2002-12. Inflammation and cancer in NATURE
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/s10517-009-0557-4

    DOI

    http://dx.doi.org/10.1007/s10517-009-0557-4

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1012187927

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/19704950


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