Use of bone marrow mesenchymal (stromal) stem cells in experimental ischemic stroke in rats View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2008-01

AUTHORS

V. I. Skvortsova, L. V. Gubskiy, R. T. Tairova, O. V. Povarova, I. B. Cheglakov, R. V. Holodenko, I. V. Holodenko, K. N. Yarygin, V. N. Yarygin

ABSTRACT

The effects of human mesenchymal stem cells on neurological functions and behavioral reactions of animals and on damaged brain tissue were studied on the model of focal cerebral ischemia in rats. Homing and differentiation of transplanted mesenchymal stem cells were also studied. Significant regression of neurological disorders after cell transplantation was noted, no appreciable shifts were detected by magnetic resonance tomography. Homing of transplanted cells was detected mainly in the zone of focal ischemia. Some cells died, others exhibited signs of differentiation into neurons and glia. More... »

PAGES

122-128

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s10517-008-0032-7

DOI

http://dx.doi.org/10.1007/s10517-008-0032-7

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1003345702

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/19024019


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