Effect of complexes of apolipoprotein A-I with tetrahydrocortisol and pregnenolone on protein biosynthesis in rat hepatocytes culture View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2007-09

AUTHORS

L. E. Panin, R. A. Knyazev, D. V. Sumenkova, L. M. Polyakov

ABSTRACT

Complexes of apolipoprotein A-I with tetrahydrocortisol and pregnenolone exhibit high biological activity and increase the rate of protein biosynthesis in the culture of rat hepatocytes. An important role in this process is played by reduced delta44-3-keto group in the A-ring of steroid hormones. A complex of apolipoprotein A-I and pregnenolone modulated the rate of protein biosynthesis in liver cells. Hence, the observed changes are not organ-specific for this steroid. Our results suggest that this mechanism of regulation play an important role in intracellular regeneration and proliferation. More... »

PAGES

291-293

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s10517-007-0313-6

DOI

http://dx.doi.org/10.1007/s10517-007-0313-6

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1003531584

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/18457017


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