Development of drug resistance in the population of colon cancer cells under the effect of multifunctional protein YB-1 View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2007-04

AUTHORS

A. V. Vaiman, T. P. Stromskaya, E. Yu. Rybalkina, A. V. Sorokin, L. P. Ovchinnikov, A. A. Stavrovskaya

ABSTRACT

The effects of YB-1 gene on the expression level of P-glycoprotein and drug resistance of tumor cells were studied in cultured HCT116 colon cancer cells. Transitory transfection of chimeric YB-1/GFP gene rendered HCT116 cells a selective advantage in a medium with vinblastine, which caused translocation of the chimeric protein into cell nuclei. This was paralleled by an increase in the expression of P-glycoprotein (multiple drug resistance protein). More... »

PAGES

463-466

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s10517-007-0157-0

DOI

http://dx.doi.org/10.1007/s10517-007-0157-0

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1027781707

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/18214301


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