Apolipoprotein A-I Possessing Activity of Defensin Proteins Modifies Structure of Plasma Membranes View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2005-10

AUTHORS

L. E. Panin, N. V. Ryazantseva, V. V. Novitskii, N. V. Tokareva

ABSTRACT

We studied the in vitro effect of apolipoprotein A-I possessing activity of defensin proteins on the structure of plasma membranes in donor erythrocytes and lymphocytes. Incubation of erythrocyte membranes with apolipoprotein A-I was accompanied by significant changes in biophysical characteristics of a fluorescent probe pyrene in the hydrophobic membrane region and a decrease in Na+/K(+)-ATPase activity. Microviscosity of annular lipids in the plasma membrane of lymphocytes increased during incubation with apolipoprotein A-I. Our results suggest that membranotropic activity of apolipoprotein A-I is associated with the presence of amphipathic alpha-helix regions. More... »

PAGES

406-409

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s10517-005-0504-y

DOI

http://dx.doi.org/10.1007/s10517-005-0504-y

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1025690028

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/16671566


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