Osteogenic Potential of Mesenchymal Stem Cells from Bone Marrow in Situ: Role of Physicochemical Properties of Artificial Surfaces View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2005-07

AUTHORS

I. A. Khlusov, A. V. Karlov, Yu. P. Sharkeev, V. F. Pichugin, Yu. P. Kolobov, G. A. Shashkina, M. B. Ivanov, E. V. Legostaeva, G. T. Sukhikh

ABSTRACT

Correlation analysis demonstrated the role of inorganic parameters of the surfaces of calcium phosphate materials in the regulation of osteogenic differentiation of mesenchymal precursors. The progenitor stromal cells were isolated from syngeneic bone marrow immobilized in vitro on calcium phosphate surfaces with different structure, phasic, and elemental composition. After 45 days of subcutaneous ectopic osteogenesis in BALB/c mice, the tissues grown on these matrixes were characterized histologically. It was found that adhesion of bone marrow cells is the initial stage determining their future proliferation (conduction) over the artificial surface and the area of formed tissue plate. The success of histogenesis depends on surface roughness. The optimal roughness class was 4-5 (Russian State Standards), which enables differentiation of progenitor stromal cells under the specific microenvironmental conditions into the connective and adipose tissue cells. Differentiation of the progenitor cells into the stromal cells producing the hemopoiesis-inducing microenvironment also takes place in the foci of active hemopoiesis. Induction of osteogenic potential of the stromal precursors (osteoinduction) is determined by the ratio between calcium and phosphate atoms in surface coatings. In our experimental system, osteogenic differentiation of stromal mechanocytes was blocked only at Ca/P<0.5. More... »

PAGES

144-152

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s10517-005-0431-y

DOI

http://dx.doi.org/10.1007/s10517-005-0431-y

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1024062570

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/16254641


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