Metformin Decelerates Aging and Development of Mammary Tumors in HER-2/neu Transgenic Mice View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2005-06

AUTHORS

V. N. Anisimov, P. A. Egormin, L. M. Bershtein, M. A. Zabezhinskii, T. S. Piskunova, I. G. Popovich, A. V. Semenchenko

ABSTRACT

Transgenic FVB/N female mice carrying HER-2/neu mammary cancer gene received metformin (1200 mg/liter) with drinking water 5 days a week starting from the age of 2 months until natural death. Metformin slightly reduced food consumption, but did not change water consumption and dynamics of weight gain. Mean life span of mice increased by 8% (p<0.05), in 10% long-living mice it was prolonged by 13.1%, and the maximum life span was prolonged by 1 month under the effect of metformin in comparison with the control. The rate of populational aging decreased by 2.26 times. The total incidence of mammary adenocarcinoma and their multiplicity did not change under the effect of metformin, while the latency of tumor development increased and the mean diameter of tumors decreased. Hence, we first demonstrated a geroprotective effect of metformin and its suppressive effect towards the development of mammary tumors. More... »

PAGES

721-723

References to SciGraph publications

  • 2004-07. Insulin-like growth factors and neoplasia in NATURE REVIEWS CANCER
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/s10517-005-0389-9

    DOI

    http://dx.doi.org/10.1007/s10517-005-0389-9

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1018298800

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/16224592


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