Peripheral blood mononuclear cell secretome for tissue repair View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2016-12

AUTHORS

Lucian Beer, Michael Mildner, Mariann Gyöngyösi, Hendrik Jan Ankersmit

ABSTRACT

For almost two decades, cell-based therapies have been tested in modern regenerative medicine to either replace or regenerate human cells, tissues, or organs and restore normal function. Secreted paracrine factors are increasingly accepted to exert beneficial biological effects that promote tissue regeneration. These factors are called the cell secretome and include a variety of proteins, lipids, microRNAs, and extracellular vesicles, such as exosomes and microparticles. The stem cell secretome has most commonly been investigated in pre-clinical settings. However, a growing body of evidence indicates that other cell types, such as peripheral blood mononuclear cells (PBMCs), are capable of releasing significant amounts of biologically active paracrine factors that exert beneficial regenerative effects. The apoptotic PBMC secretome has been successfully used pre-clinically for the treatment of acute myocardial infarction, chronic heart failure, spinal cord injury, stroke, and wound healing. In this review we describe the benefits of choosing PBMCs instead of stem cells in regenerative medicine and characterize the factors released from apoptotic PBMCs. We also discuss pre-clinical studies with apoptotic cell-based therapies and regulatory issues that have to be considered when conducting clinical trials using cell secretome-based products. This should allow the reader to envision PBMC secretome-based therapies as alternatives to all other forms of cell-based therapies. More... »

PAGES

1336-1353

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/s10495-016-1292-8

    DOI

    http://dx.doi.org/10.1007/s10495-016-1292-8

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1027192687

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/27696124


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