Curcumin induces apoptosis in human gastric carcinoma AGS cells and colon carcinoma HT-29 cells through mitochondrial dysfunction and endoplasmic reticulum ... View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2013-11

AUTHORS

Aili Cao, Qi Li, Peihao Yin, Yang Dong, Hailian Shi, Li Wang, Guang Ji, Jianqun Xie, Dazheng Wu

ABSTRACT

In the present study, we investigate the effect of curcumin, a major active component isolated from rhizomes of Curcuma longa, on the cytotoxicity of three human carcinoma cell lines (AGS, HT-29 and MGC803) in gastrointestinal tract and a normal gastric epithelial cell line GES-1, and the mechanism of curcumin-induced apoptosis. The results indicated that curcumin inhibited the gastrointestinal carcinoma cell growth in a dose-dependent manner and cytotoxicity was more towards the gastric carcinoma cell AGS and colon carcinoma cell HT-29 compared to normal gastric cell GES-1, and increased externalization of phosphatidylserine residue was observed by Annexin V/PI staining in the two cell lines. Treatment of AGS and HT-29 cells with curcumin enhanced the cleavage of procaspase-3, -7, -8 and -9. Meanwhile, curcumin induced endoplasmic reticulum (ER) stress and mitochondrial dysfunction as evidenced by up-regulation of CCAAT/enhancer binding protein homologous protein (CHOP), phosphorylation of JNK and down-regulation of SERCA2ATPase, release of cytochrome c, decrease of Bcl-2 and reduction of mitochondrial membrane potential in both AGS and HT-29 cells. Overexpression of bax, total JNK, phospho-FADD and total FADD were also observed in curcumin-treated HT-29 cells. Moreover, curcumin decreased cytosolic and ER Ca(2+), but increased mitochondrial Ca(2+) in the two cell lines. 2-Aminoethoxydiphenyl borate, an antagonist of inositol 1, 4, 5-triphosphate receptor, partly blocked curcumin-induced cytosolic Ca(2+) decrease in AGS and HT-29 cells. Additionally, carbonyl cyanide m-chlorophenylhydrazone, an inhibitor of mitochondrial Ca(2+) uptake, reversed curcumin-triggered AGS and HT-29 cells growth inhibition. siRNA to CHOP markedly reduced curcumin-induced apoptosis. These results suggest that curcumin can impact on ER stress and mitochondria functional pathways in AGS and HT-29 cells, death receptor pathway was also involved in curcumin-treated HT-29 cells, thus identifying specific well-defined molecular mechanisms that may be targeted by therapeutic strategies. More... »

PAGES

1391-1402

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s10495-013-0871-1

DOI

http://dx.doi.org/10.1007/s10495-013-0871-1

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1022833603

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/23881281


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0601", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biochemistry and Cell Biology", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biological Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Annexin A5", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Antineoplastic Agents, Phytogenic", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Apoptosis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Calcium", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Caspases", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Line, Tumor", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Proliferation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Coloring Agents", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Curcuma", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Curcumin", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Endoplasmic Reticulum Stress", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Fas-Associated Death Domain Protein", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Gene Expression Regulation, Neoplastic", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "MAP Kinase Kinase 4", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Membrane Potential, Mitochondrial", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mitochondria", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Plant Extracts", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "RNA, Small Interfering", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Sarcoplasmic Reticulum Calcium-Transporting ATPases", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Signal Transduction", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Transcription Factor CHOP", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Shanghai University of Traditional Chinese Medicine", 
          "id": "https://www.grid.ac/institutes/grid.412540.6", 
          "name": [
            "Institute of Chinese Materia Medica, Shanghai University of Traditional Chinese Medicine, 201203, Shanghai, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Cao", 
        "givenName": "Aili", 
        "id": "sg:person.0623353675.58", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0623353675.58"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Shanghai University of Traditional Chinese Medicine", 
          "id": "https://www.grid.ac/institutes/grid.412540.6", 
          "name": [
            "Putuo Hospital, Shanghai University of Traditional Chinese Medicine, 200062, Shanghai, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Li", 
        "givenName": "Qi", 
        "id": "sg:person.0630067544.93", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0630067544.93"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Shanghai University of Traditional Chinese Medicine", 
          "id": "https://www.grid.ac/institutes/grid.412540.6", 
          "name": [
            "Putuo Hospital, Shanghai University of Traditional Chinese Medicine, 200062, Shanghai, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Yin", 
        "givenName": "Peihao", 
        "id": "sg:person.0702145545.67", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0702145545.67"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Shanghai University of Traditional Chinese Medicine", 
          "id": "https://www.grid.ac/institutes/grid.412540.6", 
          "name": [
            "Institute of Chinese Materia Medica, Shanghai University of Traditional Chinese Medicine, 201203, Shanghai, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Dong", 
        "givenName": "Yang", 
        "id": "sg:person.0733236225.35", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0733236225.35"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Shanghai University of Traditional Chinese Medicine", 
          "id": "https://www.grid.ac/institutes/grid.412540.6", 
          "name": [
            "Institute of Chinese Materia Medica, Shanghai University of Traditional Chinese Medicine, 201203, Shanghai, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Shi", 
        "givenName": "Hailian", 
        "id": "sg:person.01033415434.23", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01033415434.23"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Shanghai University of Traditional Chinese Medicine", 
          "id": "https://www.grid.ac/institutes/grid.412540.6", 
          "name": [
            "Putuo Hospital, Shanghai University of Traditional Chinese Medicine, 200062, Shanghai, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Wang", 
        "givenName": "Li", 
        "id": "sg:person.01122144075.39", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01122144075.39"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Shanghai University of Traditional Chinese Medicine", 
          "id": "https://www.grid.ac/institutes/grid.412540.6", 
          "name": [
            "Institute of Digestive Diseases, Shanghai University of Traditional Chinese Medicine, 200032, Shanghai, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ji", 
        "givenName": "Guang", 
        "id": "sg:person.01111325634.82", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01111325634.82"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Shanghai University of Traditional Chinese Medicine", 
          "id": "https://www.grid.ac/institutes/grid.412540.6", 
          "name": [
            "Institute of Digestive Diseases, Shanghai University of Traditional Chinese Medicine, 200032, Shanghai, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Xie", 
        "givenName": "Jianqun", 
        "id": "sg:person.01056710255.47", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01056710255.47"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Shanghai University of Traditional Chinese Medicine", 
          "id": "https://www.grid.ac/institutes/grid.412540.6", 
          "name": [
            "Institute of Chinese Materia Medica, Shanghai University of Traditional Chinese Medicine, 201203, Shanghai, China", 
            "Putuo Hospital, Shanghai University of Traditional Chinese Medicine, 200062, Shanghai, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Wu", 
        "givenName": "Dazheng", 
        "id": "sg:person.0635145643.83", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0635145643.83"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1038/sj.onc.1205947", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000850141", 
          "https://doi.org/10.1038/sj.onc.1205947"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.onc.1205947", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000850141", 
          "https://doi.org/10.1038/sj.onc.1205947"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/35037710", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003551467", 
          "https://doi.org/10.1038/35037710"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/35037710", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003551467", 
          "https://doi.org/10.1038/35037710"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/cddis.2011.78", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004236712", 
          "https://doi.org/10.1038/cddis.2011.78"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m502685200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005107786"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m502685200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005107786"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/1078-0432.ccr-04-0744", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005777798"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.pharmthera.2012.02.003", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005910893"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10495-009-0430-y", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007861013", 
          "https://doi.org/10.1007/s10495-009-0430-y"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10495-009-0430-y", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007861013", 
          "https://doi.org/10.1007/s10495-009-0430-y"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10495-009-0430-y", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007861013", 
          "https://doi.org/10.1007/s10495-009-0430-y"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0378-8741(98)00234-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011017752"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.97.11.5723", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012027047"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2337/db07-1762", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014020139"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10495-008-0221-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014667948", 
          "https://doi.org/10.1007/s10495-008-0221-x"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10495-008-0221-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014667948", 
          "https://doi.org/10.1007/s10495-008-0221-x"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10495-007-0747-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016550689", 
          "https://doi.org/10.1007/s10495-007-0747-3"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10495-007-0747-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016550689", 
          "https://doi.org/10.1007/s10495-007-0747-3"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.cdd.4401373", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017102639", 
          "https://doi.org/10.1038/sj.cdd.4401373"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.cdd.4401373", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017102639", 
          "https://doi.org/10.1038/sj.cdd.4401373"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/mc.20103", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018269498"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m108778200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020725532"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pone.0025976", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026417318"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.bbrc.2008.05.138", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026868264"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pone.0031905", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026878143"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/carcin/bgi167", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027681712"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1124/mol.107.043554", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029877957"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10495-010-0461-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030437218", 
          "https://doi.org/10.1007/s10495-010-0461-4"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10495-010-0461-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030437218", 
          "https://doi.org/10.1007/s10495-010-0461-4"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.bbrc.2009.10.141", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030761646"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4236/jct.2010.13018", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032740916"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1124/jpet.102.042457", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032817364"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1471-4159.2007.05048.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033992276"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/gut.44.2.156", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034387340"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s11010-005-7717-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034797733", 
          "https://doi.org/10.1007/s11010-005-7717-2"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s11010-005-7717-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034797733", 
          "https://doi.org/10.1007/s11010-005-7717-2"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.freeradbiomed.2008.08.014", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035419222"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0014-5793(99)00969-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035703517"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/mcb.21.4.1249-1259.2001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036338208"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m111155200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042128103"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0092-8674(00)81590-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042580199"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/01.hyp.0000153320.13842.43", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042617828"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/01.hyp.0000153320.13842.43", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042617828"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/0008-5472.can-05-2016", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044363440"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1080/10715760701762407", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045895674"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0006-291x(03)00479-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046656811"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0006-291x(03)00479-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046656811"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2147/ijn.s36257", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048819236"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1046/j.0014-2956.2001.02589.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049807922"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/eye.2009.20", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052229375", 
          "https://doi.org/10.1038/eye.2009.20"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ejphar.2010.09.049", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053481520"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1089/ars.2007.1769", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1059230659"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3748/wjg.v9.i7.1415", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1071375790"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4161/cbt.6.2.3577", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1072294447"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4161/cbt.8.2.7087", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1072295322"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1523/jneurosci.21-24-09519.2001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1074962512"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2013-11", 
    "datePublishedReg": "2013-11-01", 
    "description": "In the present study, we investigate the effect of curcumin, a major active component isolated from rhizomes of Curcuma longa, on the cytotoxicity of three human carcinoma cell lines (AGS, HT-29 and MGC803) in gastrointestinal tract and a normal gastric epithelial cell line GES-1, and the mechanism of curcumin-induced apoptosis. The results indicated that curcumin inhibited the gastrointestinal carcinoma cell growth in a dose-dependent manner and cytotoxicity was more towards the gastric carcinoma cell AGS and colon carcinoma cell HT-29 compared to normal gastric cell GES-1, and increased externalization of phosphatidylserine residue was observed by Annexin V/PI staining in the two cell lines. Treatment of AGS and HT-29 cells with curcumin enhanced the cleavage of procaspase-3, -7, -8 and -9. Meanwhile, curcumin induced endoplasmic reticulum (ER) stress and mitochondrial dysfunction as evidenced by up-regulation of CCAAT/enhancer binding protein homologous protein (CHOP), phosphorylation of JNK and down-regulation of SERCA2ATPase, release of cytochrome c, decrease of Bcl-2 and reduction of mitochondrial membrane potential in both AGS and HT-29 cells. Overexpression of bax, total JNK, phospho-FADD and total FADD were also observed in curcumin-treated HT-29 cells. Moreover, curcumin decreased cytosolic and ER Ca(2+), but increased mitochondrial Ca(2+) in the two cell lines. 2-Aminoethoxydiphenyl borate, an antagonist of inositol 1, 4, 5-triphosphate receptor, partly blocked curcumin-induced cytosolic Ca(2+) decrease in AGS and HT-29 cells. Additionally, carbonyl cyanide m-chlorophenylhydrazone, an inhibitor of mitochondrial Ca(2+) uptake, reversed curcumin-triggered AGS and HT-29 cells growth inhibition. siRNA to CHOP markedly reduced curcumin-induced apoptosis. These results suggest that curcumin can impact on ER stress and mitochondria functional pathways in AGS and HT-29 cells, death receptor pathway was also involved in curcumin-treated HT-29 cells, thus identifying specific well-defined molecular mechanisms that may be targeted by therapeutic strategies.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1007/s10495-013-0871-1", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1117236", 
        "issn": [
          "1360-8185", 
          "1573-675X"
        ], 
        "name": "Apoptosis", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "11", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "18"
      }
    ], 
    "name": "Curcumin induces apoptosis in human gastric carcinoma AGS cells and colon carcinoma HT-29 cells through mitochondrial dysfunction and endoplasmic reticulum stress", 
    "pagination": "1391-1402", 
    "productId": [
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s10495-013-0871-1"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1022833603"
        ]
      }, 
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "6cc8caa5f2b66016aa55ecf84d8fe16c558a9faba047afa27ad1c7605cb01c45"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "9712129"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "23881281"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s10495-013-0871-1", 
      "https://app.dimensions.ai/details/publication/pub.1022833603"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-16T06:21", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000377_0000000377/records_106804_00000000.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://link.springer.com/10.1007%2Fs10495-013-0871-1"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s10495-013-0871-1'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s10495-013-0871-1'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s10495-013-0871-1'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s10495-013-0871-1'


 

This table displays all metadata directly associated to this object as RDF triples.

360 TRIPLES      21 PREDICATES      96 URIs      43 LITERALS      31 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s10495-013-0871-1 schema:about N181172053f3445e48104481769f98593
2 N33dfa170b7bc4c449e927ee899cc6c6b
3 N3416036df9be4f3799f1fe10599af5cc
4 N4993bd1b2f4d4eff8f17bf470fc1b323
5 N4f423de7f6a84d95a2d1c81e156ca7b6
6 N54cb42b839a944478d39acf7880eac1e
7 N5db477825bed4447827eb0af07562810
8 N676b74e91d4e4ba3b8c67247f620f446
9 N6a268d1a9cae4044bf9f030dcfd6851d
10 N7b315ee1a4d94a6cbf5d02c488b291e3
11 N847effd691d94927be2963335c3edbb0
12 N98424f23428843559ea344d49d056fde
13 Na3c3fb76c0774a40a8acc81fa4920c84
14 Nba5ac23a90564d4a8bfea06749935c34
15 Nbc8370a3bce74dbc8b76b2c90f3a0de4
16 Nd2970b88e9a9402986b8fbafecda8653
17 Nd3f947d05a8b4e079babf430c8429afb
18 Ndd37556c074f4ff9a557b410b5432b1d
19 Ndee8be25541a47eba7d08550b60cfaaf
20 Ne86c88b9e86a4cbc86e9825ed0b629e7
21 Ne8b3f5f658aa454bae6a557dd61b2bd3
22 Nf1e08d7063ab451794cdc224790840bf
23 anzsrc-for:06
24 anzsrc-for:0601
25 schema:author Nfa1ada04dab74152a3b749673989d26f
26 schema:citation sg:pub.10.1007/s10495-007-0747-3
27 sg:pub.10.1007/s10495-008-0221-x
28 sg:pub.10.1007/s10495-009-0430-y
29 sg:pub.10.1007/s10495-010-0461-4
30 sg:pub.10.1007/s11010-005-7717-2
31 sg:pub.10.1038/35037710
32 sg:pub.10.1038/cddis.2011.78
33 sg:pub.10.1038/eye.2009.20
34 sg:pub.10.1038/sj.cdd.4401373
35 sg:pub.10.1038/sj.onc.1205947
36 https://doi.org/10.1002/mc.20103
37 https://doi.org/10.1016/j.bbrc.2008.05.138
38 https://doi.org/10.1016/j.bbrc.2009.10.141
39 https://doi.org/10.1016/j.ejphar.2010.09.049
40 https://doi.org/10.1016/j.freeradbiomed.2008.08.014
41 https://doi.org/10.1016/j.pharmthera.2012.02.003
42 https://doi.org/10.1016/s0006-291x(03)00479-0
43 https://doi.org/10.1016/s0014-5793(99)00969-2
44 https://doi.org/10.1016/s0092-8674(00)81590-1
45 https://doi.org/10.1016/s0378-8741(98)00234-7
46 https://doi.org/10.1046/j.0014-2956.2001.02589.x
47 https://doi.org/10.1073/pnas.97.11.5723
48 https://doi.org/10.1074/jbc.m108778200
49 https://doi.org/10.1074/jbc.m111155200
50 https://doi.org/10.1074/jbc.m502685200
51 https://doi.org/10.1080/10715760701762407
52 https://doi.org/10.1089/ars.2007.1769
53 https://doi.org/10.1093/carcin/bgi167
54 https://doi.org/10.1111/j.1471-4159.2007.05048.x
55 https://doi.org/10.1124/jpet.102.042457
56 https://doi.org/10.1124/mol.107.043554
57 https://doi.org/10.1128/mcb.21.4.1249-1259.2001
58 https://doi.org/10.1136/gut.44.2.156
59 https://doi.org/10.1158/0008-5472.can-05-2016
60 https://doi.org/10.1158/1078-0432.ccr-04-0744
61 https://doi.org/10.1161/01.hyp.0000153320.13842.43
62 https://doi.org/10.1371/journal.pone.0025976
63 https://doi.org/10.1371/journal.pone.0031905
64 https://doi.org/10.1523/jneurosci.21-24-09519.2001
65 https://doi.org/10.2147/ijn.s36257
66 https://doi.org/10.2337/db07-1762
67 https://doi.org/10.3748/wjg.v9.i7.1415
68 https://doi.org/10.4161/cbt.6.2.3577
69 https://doi.org/10.4161/cbt.8.2.7087
70 https://doi.org/10.4236/jct.2010.13018
71 schema:datePublished 2013-11
72 schema:datePublishedReg 2013-11-01
73 schema:description In the present study, we investigate the effect of curcumin, a major active component isolated from rhizomes of Curcuma longa, on the cytotoxicity of three human carcinoma cell lines (AGS, HT-29 and MGC803) in gastrointestinal tract and a normal gastric epithelial cell line GES-1, and the mechanism of curcumin-induced apoptosis. The results indicated that curcumin inhibited the gastrointestinal carcinoma cell growth in a dose-dependent manner and cytotoxicity was more towards the gastric carcinoma cell AGS and colon carcinoma cell HT-29 compared to normal gastric cell GES-1, and increased externalization of phosphatidylserine residue was observed by Annexin V/PI staining in the two cell lines. Treatment of AGS and HT-29 cells with curcumin enhanced the cleavage of procaspase-3, -7, -8 and -9. Meanwhile, curcumin induced endoplasmic reticulum (ER) stress and mitochondrial dysfunction as evidenced by up-regulation of CCAAT/enhancer binding protein homologous protein (CHOP), phosphorylation of JNK and down-regulation of SERCA2ATPase, release of cytochrome c, decrease of Bcl-2 and reduction of mitochondrial membrane potential in both AGS and HT-29 cells. Overexpression of bax, total JNK, phospho-FADD and total FADD were also observed in curcumin-treated HT-29 cells. Moreover, curcumin decreased cytosolic and ER Ca(2+), but increased mitochondrial Ca(2+) in the two cell lines. 2-Aminoethoxydiphenyl borate, an antagonist of inositol 1, 4, 5-triphosphate receptor, partly blocked curcumin-induced cytosolic Ca(2+) decrease in AGS and HT-29 cells. Additionally, carbonyl cyanide m-chlorophenylhydrazone, an inhibitor of mitochondrial Ca(2+) uptake, reversed curcumin-triggered AGS and HT-29 cells growth inhibition. siRNA to CHOP markedly reduced curcumin-induced apoptosis. These results suggest that curcumin can impact on ER stress and mitochondria functional pathways in AGS and HT-29 cells, death receptor pathway was also involved in curcumin-treated HT-29 cells, thus identifying specific well-defined molecular mechanisms that may be targeted by therapeutic strategies.
74 schema:genre research_article
75 schema:inLanguage en
76 schema:isAccessibleForFree false
77 schema:isPartOf N976f26960ae440638bf0ac096ea6ff87
78 Nd659e67ea0004dc8a9670df8e79d3b22
79 sg:journal.1117236
80 schema:name Curcumin induces apoptosis in human gastric carcinoma AGS cells and colon carcinoma HT-29 cells through mitochondrial dysfunction and endoplasmic reticulum stress
81 schema:pagination 1391-1402
82 schema:productId N7d1b235413a9430bb5c3d47d2528d6c6
83 Nc6c606f3b5ce46bd9808d9c1dfa63381
84 Nd2b4750d9d5b4a27ab1b9cbedfc9b5ab
85 Nea09358b89654809a9f5d86105e8d52b
86 Nf1ab74d9dc1148fe91382107aac0db20
87 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022833603
88 https://doi.org/10.1007/s10495-013-0871-1
89 schema:sdDatePublished 2019-04-16T06:21
90 schema:sdLicense https://scigraph.springernature.com/explorer/license/
91 schema:sdPublisher N692bb20c24e744c1a060e680fb0c9ce7
92 schema:url http://link.springer.com/10.1007%2Fs10495-013-0871-1
93 sgo:license sg:explorer/license/
94 sgo:sdDataset articles
95 rdf:type schema:ScholarlyArticle
96 N181172053f3445e48104481769f98593 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
97 schema:name Calcium
98 rdf:type schema:DefinedTerm
99 N2e61d7ee2cf848dfadcd9d5d3b7c9ea6 rdf:first sg:person.01033415434.23
100 rdf:rest N877483c34dfd492091cf9ff6b4538e11
101 N32efb9b6df454915968e7730bae62c27 rdf:first sg:person.0702145545.67
102 rdf:rest Nc2d09042920549548d09f1225440221d
103 N33dfa170b7bc4c449e927ee899cc6c6b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
104 schema:name Annexin A5
105 rdf:type schema:DefinedTerm
106 N3416036df9be4f3799f1fe10599af5cc schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
107 schema:name Transcription Factor CHOP
108 rdf:type schema:DefinedTerm
109 N4993bd1b2f4d4eff8f17bf470fc1b323 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
110 schema:name Mitochondria
111 rdf:type schema:DefinedTerm
112 N4f423de7f6a84d95a2d1c81e156ca7b6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
113 schema:name Signal Transduction
114 rdf:type schema:DefinedTerm
115 N54cb42b839a944478d39acf7880eac1e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
116 schema:name Cell Proliferation
117 rdf:type schema:DefinedTerm
118 N5db477825bed4447827eb0af07562810 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
119 schema:name Apoptosis
120 rdf:type schema:DefinedTerm
121 N676b74e91d4e4ba3b8c67247f620f446 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
122 schema:name Caspases
123 rdf:type schema:DefinedTerm
124 N692bb20c24e744c1a060e680fb0c9ce7 schema:name Springer Nature - SN SciGraph project
125 rdf:type schema:Organization
126 N6a268d1a9cae4044bf9f030dcfd6851d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
127 schema:name Sarcoplasmic Reticulum Calcium-Transporting ATPases
128 rdf:type schema:DefinedTerm
129 N7b315ee1a4d94a6cbf5d02c488b291e3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
130 schema:name Curcumin
131 rdf:type schema:DefinedTerm
132 N7d1b235413a9430bb5c3d47d2528d6c6 schema:name nlm_unique_id
133 schema:value 9712129
134 rdf:type schema:PropertyValue
135 N847effd691d94927be2963335c3edbb0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
136 schema:name RNA, Small Interfering
137 rdf:type schema:DefinedTerm
138 N877483c34dfd492091cf9ff6b4538e11 rdf:first sg:person.01122144075.39
139 rdf:rest Nbb4b392aab13481aab075ad68b5973ca
140 N976f26960ae440638bf0ac096ea6ff87 schema:issueNumber 11
141 rdf:type schema:PublicationIssue
142 N98424f23428843559ea344d49d056fde schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
143 schema:name Fas-Associated Death Domain Protein
144 rdf:type schema:DefinedTerm
145 Na3c3fb76c0774a40a8acc81fa4920c84 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
146 schema:name Coloring Agents
147 rdf:type schema:DefinedTerm
148 Nba5ac23a90564d4a8bfea06749935c34 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
149 schema:name Plant Extracts
150 rdf:type schema:DefinedTerm
151 Nbb4b392aab13481aab075ad68b5973ca rdf:first sg:person.01111325634.82
152 rdf:rest Nfddb8cab743847bfa45cd9030112f5c3
153 Nbc8370a3bce74dbc8b76b2c90f3a0de4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
154 schema:name Humans
155 rdf:type schema:DefinedTerm
156 Nc2d09042920549548d09f1225440221d rdf:first sg:person.0733236225.35
157 rdf:rest N2e61d7ee2cf848dfadcd9d5d3b7c9ea6
158 Nc6c606f3b5ce46bd9808d9c1dfa63381 schema:name readcube_id
159 schema:value 6cc8caa5f2b66016aa55ecf84d8fe16c558a9faba047afa27ad1c7605cb01c45
160 rdf:type schema:PropertyValue
161 Ncf71bc51f51e4f9cb6313c4cc6ef4a27 rdf:first sg:person.0635145643.83
162 rdf:rest rdf:nil
163 Nd2970b88e9a9402986b8fbafecda8653 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
164 schema:name Membrane Potential, Mitochondrial
165 rdf:type schema:DefinedTerm
166 Nd2b4750d9d5b4a27ab1b9cbedfc9b5ab schema:name pubmed_id
167 schema:value 23881281
168 rdf:type schema:PropertyValue
169 Nd3f947d05a8b4e079babf430c8429afb schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
170 schema:name Antineoplastic Agents, Phytogenic
171 rdf:type schema:DefinedTerm
172 Nd659e67ea0004dc8a9670df8e79d3b22 schema:volumeNumber 18
173 rdf:type schema:PublicationVolume
174 Nd92f708528144534b8aefcfb9399e8dc rdf:first sg:person.0630067544.93
175 rdf:rest N32efb9b6df454915968e7730bae62c27
176 Ndd37556c074f4ff9a557b410b5432b1d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
177 schema:name MAP Kinase Kinase 4
178 rdf:type schema:DefinedTerm
179 Ndee8be25541a47eba7d08550b60cfaaf schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
180 schema:name Endoplasmic Reticulum Stress
181 rdf:type schema:DefinedTerm
182 Ne86c88b9e86a4cbc86e9825ed0b629e7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
183 schema:name Gene Expression Regulation, Neoplastic
184 rdf:type schema:DefinedTerm
185 Ne8b3f5f658aa454bae6a557dd61b2bd3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
186 schema:name Cell Line, Tumor
187 rdf:type schema:DefinedTerm
188 Nea09358b89654809a9f5d86105e8d52b schema:name dimensions_id
189 schema:value pub.1022833603
190 rdf:type schema:PropertyValue
191 Nf1ab74d9dc1148fe91382107aac0db20 schema:name doi
192 schema:value 10.1007/s10495-013-0871-1
193 rdf:type schema:PropertyValue
194 Nf1e08d7063ab451794cdc224790840bf schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
195 schema:name Curcuma
196 rdf:type schema:DefinedTerm
197 Nfa1ada04dab74152a3b749673989d26f rdf:first sg:person.0623353675.58
198 rdf:rest Nd92f708528144534b8aefcfb9399e8dc
199 Nfddb8cab743847bfa45cd9030112f5c3 rdf:first sg:person.01056710255.47
200 rdf:rest Ncf71bc51f51e4f9cb6313c4cc6ef4a27
201 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
202 schema:name Biological Sciences
203 rdf:type schema:DefinedTerm
204 anzsrc-for:0601 schema:inDefinedTermSet anzsrc-for:
205 schema:name Biochemistry and Cell Biology
206 rdf:type schema:DefinedTerm
207 sg:journal.1117236 schema:issn 1360-8185
208 1573-675X
209 schema:name Apoptosis
210 rdf:type schema:Periodical
211 sg:person.01033415434.23 schema:affiliation https://www.grid.ac/institutes/grid.412540.6
212 schema:familyName Shi
213 schema:givenName Hailian
214 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01033415434.23
215 rdf:type schema:Person
216 sg:person.01056710255.47 schema:affiliation https://www.grid.ac/institutes/grid.412540.6
217 schema:familyName Xie
218 schema:givenName Jianqun
219 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01056710255.47
220 rdf:type schema:Person
221 sg:person.01111325634.82 schema:affiliation https://www.grid.ac/institutes/grid.412540.6
222 schema:familyName Ji
223 schema:givenName Guang
224 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01111325634.82
225 rdf:type schema:Person
226 sg:person.01122144075.39 schema:affiliation https://www.grid.ac/institutes/grid.412540.6
227 schema:familyName Wang
228 schema:givenName Li
229 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01122144075.39
230 rdf:type schema:Person
231 sg:person.0623353675.58 schema:affiliation https://www.grid.ac/institutes/grid.412540.6
232 schema:familyName Cao
233 schema:givenName Aili
234 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0623353675.58
235 rdf:type schema:Person
236 sg:person.0630067544.93 schema:affiliation https://www.grid.ac/institutes/grid.412540.6
237 schema:familyName Li
238 schema:givenName Qi
239 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0630067544.93
240 rdf:type schema:Person
241 sg:person.0635145643.83 schema:affiliation https://www.grid.ac/institutes/grid.412540.6
242 schema:familyName Wu
243 schema:givenName Dazheng
244 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0635145643.83
245 rdf:type schema:Person
246 sg:person.0702145545.67 schema:affiliation https://www.grid.ac/institutes/grid.412540.6
247 schema:familyName Yin
248 schema:givenName Peihao
249 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0702145545.67
250 rdf:type schema:Person
251 sg:person.0733236225.35 schema:affiliation https://www.grid.ac/institutes/grid.412540.6
252 schema:familyName Dong
253 schema:givenName Yang
254 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0733236225.35
255 rdf:type schema:Person
256 sg:pub.10.1007/s10495-007-0747-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016550689
257 https://doi.org/10.1007/s10495-007-0747-3
258 rdf:type schema:CreativeWork
259 sg:pub.10.1007/s10495-008-0221-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1014667948
260 https://doi.org/10.1007/s10495-008-0221-x
261 rdf:type schema:CreativeWork
262 sg:pub.10.1007/s10495-009-0430-y schema:sameAs https://app.dimensions.ai/details/publication/pub.1007861013
263 https://doi.org/10.1007/s10495-009-0430-y
264 rdf:type schema:CreativeWork
265 sg:pub.10.1007/s10495-010-0461-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030437218
266 https://doi.org/10.1007/s10495-010-0461-4
267 rdf:type schema:CreativeWork
268 sg:pub.10.1007/s11010-005-7717-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034797733
269 https://doi.org/10.1007/s11010-005-7717-2
270 rdf:type schema:CreativeWork
271 sg:pub.10.1038/35037710 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003551467
272 https://doi.org/10.1038/35037710
273 rdf:type schema:CreativeWork
274 sg:pub.10.1038/cddis.2011.78 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004236712
275 https://doi.org/10.1038/cddis.2011.78
276 rdf:type schema:CreativeWork
277 sg:pub.10.1038/eye.2009.20 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052229375
278 https://doi.org/10.1038/eye.2009.20
279 rdf:type schema:CreativeWork
280 sg:pub.10.1038/sj.cdd.4401373 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017102639
281 https://doi.org/10.1038/sj.cdd.4401373
282 rdf:type schema:CreativeWork
283 sg:pub.10.1038/sj.onc.1205947 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000850141
284 https://doi.org/10.1038/sj.onc.1205947
285 rdf:type schema:CreativeWork
286 https://doi.org/10.1002/mc.20103 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018269498
287 rdf:type schema:CreativeWork
288 https://doi.org/10.1016/j.bbrc.2008.05.138 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026868264
289 rdf:type schema:CreativeWork
290 https://doi.org/10.1016/j.bbrc.2009.10.141 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030761646
291 rdf:type schema:CreativeWork
292 https://doi.org/10.1016/j.ejphar.2010.09.049 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053481520
293 rdf:type schema:CreativeWork
294 https://doi.org/10.1016/j.freeradbiomed.2008.08.014 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035419222
295 rdf:type schema:CreativeWork
296 https://doi.org/10.1016/j.pharmthera.2012.02.003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005910893
297 rdf:type schema:CreativeWork
298 https://doi.org/10.1016/s0006-291x(03)00479-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046656811
299 rdf:type schema:CreativeWork
300 https://doi.org/10.1016/s0014-5793(99)00969-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035703517
301 rdf:type schema:CreativeWork
302 https://doi.org/10.1016/s0092-8674(00)81590-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042580199
303 rdf:type schema:CreativeWork
304 https://doi.org/10.1016/s0378-8741(98)00234-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011017752
305 rdf:type schema:CreativeWork
306 https://doi.org/10.1046/j.0014-2956.2001.02589.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1049807922
307 rdf:type schema:CreativeWork
308 https://doi.org/10.1073/pnas.97.11.5723 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012027047
309 rdf:type schema:CreativeWork
310 https://doi.org/10.1074/jbc.m108778200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020725532
311 rdf:type schema:CreativeWork
312 https://doi.org/10.1074/jbc.m111155200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042128103
313 rdf:type schema:CreativeWork
314 https://doi.org/10.1074/jbc.m502685200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005107786
315 rdf:type schema:CreativeWork
316 https://doi.org/10.1080/10715760701762407 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045895674
317 rdf:type schema:CreativeWork
318 https://doi.org/10.1089/ars.2007.1769 schema:sameAs https://app.dimensions.ai/details/publication/pub.1059230659
319 rdf:type schema:CreativeWork
320 https://doi.org/10.1093/carcin/bgi167 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027681712
321 rdf:type schema:CreativeWork
322 https://doi.org/10.1111/j.1471-4159.2007.05048.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1033992276
323 rdf:type schema:CreativeWork
324 https://doi.org/10.1124/jpet.102.042457 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032817364
325 rdf:type schema:CreativeWork
326 https://doi.org/10.1124/mol.107.043554 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029877957
327 rdf:type schema:CreativeWork
328 https://doi.org/10.1128/mcb.21.4.1249-1259.2001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036338208
329 rdf:type schema:CreativeWork
330 https://doi.org/10.1136/gut.44.2.156 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034387340
331 rdf:type schema:CreativeWork
332 https://doi.org/10.1158/0008-5472.can-05-2016 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044363440
333 rdf:type schema:CreativeWork
334 https://doi.org/10.1158/1078-0432.ccr-04-0744 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005777798
335 rdf:type schema:CreativeWork
336 https://doi.org/10.1161/01.hyp.0000153320.13842.43 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042617828
337 rdf:type schema:CreativeWork
338 https://doi.org/10.1371/journal.pone.0025976 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026417318
339 rdf:type schema:CreativeWork
340 https://doi.org/10.1371/journal.pone.0031905 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026878143
341 rdf:type schema:CreativeWork
342 https://doi.org/10.1523/jneurosci.21-24-09519.2001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1074962512
343 rdf:type schema:CreativeWork
344 https://doi.org/10.2147/ijn.s36257 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048819236
345 rdf:type schema:CreativeWork
346 https://doi.org/10.2337/db07-1762 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014020139
347 rdf:type schema:CreativeWork
348 https://doi.org/10.3748/wjg.v9.i7.1415 schema:sameAs https://app.dimensions.ai/details/publication/pub.1071375790
349 rdf:type schema:CreativeWork
350 https://doi.org/10.4161/cbt.6.2.3577 schema:sameAs https://app.dimensions.ai/details/publication/pub.1072294447
351 rdf:type schema:CreativeWork
352 https://doi.org/10.4161/cbt.8.2.7087 schema:sameAs https://app.dimensions.ai/details/publication/pub.1072295322
353 rdf:type schema:CreativeWork
354 https://doi.org/10.4236/jct.2010.13018 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032740916
355 rdf:type schema:CreativeWork
356 https://www.grid.ac/institutes/grid.412540.6 schema:alternateName Shanghai University of Traditional Chinese Medicine
357 schema:name Institute of Chinese Materia Medica, Shanghai University of Traditional Chinese Medicine, 201203, Shanghai, China
358 Institute of Digestive Diseases, Shanghai University of Traditional Chinese Medicine, 200032, Shanghai, China
359 Putuo Hospital, Shanghai University of Traditional Chinese Medicine, 200062, Shanghai, China
360 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...