MAPK p38 and JNK have opposing activities on TRAIL-induced apoptosis activation in NSCLC H460 cells that involves RIP1 and caspase-8 ... View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2013-07

AUTHORS

Kaamar Azijli, Saravanan Yuvaraj, Ingrid van Roosmalen, Koen Flach, Elisa Giovannetti, Godefridus J. Peters, Steven de Jong, Frank A. E. Kruyt

ABSTRACT

Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) can induce both caspase-dependent apoptosis and kinase activation in tumor cells. Here, we examined the consequences and mechanisms of TRAIL-induced MAPKs p38 and JNK in non-small cell lung cancer (NSCLC) cells. In apoptosis sensitive H460 cells, these kinases were phosphorylated, but not in resistant A549 cells. Time course experiments in H460 cells showed that induction of p38 phosphorylation preceded that of JNK. To explore the function of these kinases in apoptosis activation by TRAIL, chemical inhibitors or siRNAs were employed to impair JNK or p38 functioning. JNK activation counteracted TRAIL-induced apoptosis whereas activation of p38 stimulated apoptosis. Notably, the serine/threonine kinase RIP1 was cleaved following TRAIL treatment, concomitant with detectable JNK phosphorylation. Further examination of the role of RIP1 by short hairpin (sh)RNA-dependent knockdown or inhibition by necrostatin-1 showed that p38 can be phosphorylated in both RIP1-dependent and -independent manner, whereas JNK phosphorylation occurred independent of RIP1. On the other hand JNK appeared to suppress RIP1 cleavage via an unknown mechanism. In addition, only the activation of JNK by TRAIL was caspase-8-dependent. Finally, we identified Mcl-1, a known substrate for p38 and JNK, as a downstream modulator of JNK or p38 activity. Collectively, our data suggest in a subset of NSCLC cells a model in which TRAIL-induced activation of p38 and JNK have counteracting effects on Mcl-1 expression leading to pro- or anti-apoptotic effects, respectively. Strategies aiming to stimulate p38 and inhibit JNK may have benefit for TRAIL-based therapies in NSCLC. More... »

PAGES

851-860

References to SciGraph publications

  • 2009-02-25. Imaging Systems for Westerns: Chemiluminescence vs. Infrared Detection in PROTEIN BLOTTING AND DETECTION
  • 2005-03. Mechanisms of resistance to TRAIL-induced apoptosis in cancer in CANCER GENE THERAPY
  • 2009-05. Differential activation of JNK1 isoforms by TRAIL receptors modulate apoptosis of colon cancer cell lines in BRITISH JOURNAL OF CANCER
  • 2010-08. New insights into apoptosis signaling by Apo2L/TRAIL in ONCOGENE
  • 2011-11. Preclinical emergence of vandetanib as a potent antitumour agent in mesothelioma: molecular mechanisms underlying its synergistic interaction with pemetrexed and carboplatin in BRITISH JOURNAL OF CANCER
  • 2008-05. Identification of RIP1 kinase as a specific cellular target of necrostatins in NATURE CHEMICAL BIOLOGY
  • 2003-05. Activation of ERK1/2 protects melanoma cells from TRAIL-induced apoptosis by inhibiting Smac/DIABLO release from mitochondria in ONCOGENE
  • 2008-09. Bcl2, a transcriptional target of p38α, is critical for neuronal commitment of mouse embryonic stem cells in CELL DEATH & DIFFERENTIATION
  • 2007-03. RIP1, a kinase on the crossroads of a cell's decision to live or die in CELL DEATH & DIFFERENTIATION
  • 2008-11. The complexity of mitogen-activated protein kinases (MAPKs) made simple in CELLULAR AND MOLECULAR LIFE SCIENCES
  • 2010-08. TRAIL-activated stress kinases suppress apoptosis through transcriptional upregulation of MCL-1 in CELL DEATH & DIFFERENTIATION
  • 2008-10. The TRAIL apoptotic pathway in cancer onset, progression and therapy in NATURE REVIEWS CANCER
  • 2004-07. MCL1 is phosphorylated in the PEST region and stabilized upon ERK activation in viable cells, and at additional sites with cytotoxic okadaic acid or taxol in ONCOGENE
  • 2004-10. Inhibition of the NF-κB pathway enhances TRAIL-mediated apoptosis in neuroblastoma cells in CANCER GENE THERAPY
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/s10495-013-0829-3

    DOI

    http://dx.doi.org/10.1007/s10495-013-0829-3

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1007289907

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/23456625


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0601", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Biochemistry and Cell Biology", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Biological Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Apoptosis", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Carcinoma, Non-Small-Cell Lung", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Caspase 8", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Cell Line, Tumor", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Cell Proliferation", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Drug Resistance, Neoplasm", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Gene Expression Regulation, Neoplastic", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Humans", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Imidazoles", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Indoles", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Lung Neoplasms", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "MAP Kinase Kinase 4", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Myeloid Cell Leukemia Sequence 1 Protein", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Nuclear Pore Complex Proteins", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Organ Specificity", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Phosphorylation", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Proteolysis", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "RNA, Small Interfering", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "RNA-Binding Proteins", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Signal Transduction", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "TNF-Related Apoptosis-Inducing Ligand", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "p38 Mitogen-Activated Protein Kinases", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "VU University Medical Center", 
              "id": "https://www.grid.ac/institutes/grid.16872.3a", 
              "name": [
                "Department of Medical Oncology, University of Groningen, University Medical Center Groningen, Hanzeplein 1, 9713 GZ, Groningen, The Netherlands", 
                "Department of Medical Oncology, VU University Medical Center, Amsterdam, The Netherlands"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Azijli", 
            "givenName": "Kaamar", 
            "id": "sg:person.01313446176.81", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01313446176.81"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University Medical Center Groningen", 
              "id": "https://www.grid.ac/institutes/grid.4494.d", 
              "name": [
                "Department of Medical Oncology, University of Groningen, University Medical Center Groningen, Hanzeplein 1, 9713 GZ, Groningen, The Netherlands"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Yuvaraj", 
            "givenName": "Saravanan", 
            "id": "sg:person.0652615675.63", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0652615675.63"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of Groningen", 
              "id": "https://www.grid.ac/institutes/grid.4830.f", 
              "name": [
                "Department of Pharmaceutical Biology, University of Groningen, Groningen, The Netherlands"
              ], 
              "type": "Organization"
            }, 
            "familyName": "van Roosmalen", 
            "givenName": "Ingrid", 
            "id": "sg:person.0604510331.42", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0604510331.42"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "VU University Medical Center", 
              "id": "https://www.grid.ac/institutes/grid.16872.3a", 
              "name": [
                "Department of Medical Oncology, VU University Medical Center, Amsterdam, The Netherlands"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Flach", 
            "givenName": "Koen", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "VU University Medical Center", 
              "id": "https://www.grid.ac/institutes/grid.16872.3a", 
              "name": [
                "Department of Medical Oncology, VU University Medical Center, Amsterdam, The Netherlands"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Giovannetti", 
            "givenName": "Elisa", 
            "id": "sg:person.0577505063.56", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0577505063.56"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "VU University Medical Center", 
              "id": "https://www.grid.ac/institutes/grid.16872.3a", 
              "name": [
                "Department of Medical Oncology, VU University Medical Center, Amsterdam, The Netherlands"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Peters", 
            "givenName": "Godefridus J.", 
            "id": "sg:person.01255301342.17", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01255301342.17"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University Medical Center Groningen", 
              "id": "https://www.grid.ac/institutes/grid.4494.d", 
              "name": [
                "Department of Medical Oncology, University of Groningen, University Medical Center Groningen, Hanzeplein 1, 9713 GZ, Groningen, The Netherlands"
              ], 
              "type": "Organization"
            }, 
            "familyName": "de Jong", 
            "givenName": "Steven", 
            "id": "sg:person.0701617307.93", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0701617307.93"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University Medical Center Groningen", 
              "id": "https://www.grid.ac/institutes/grid.4494.d", 
              "name": [
                "Department of Medical Oncology, University of Groningen, University Medical Center Groningen, Hanzeplein 1, 9713 GZ, Groningen, The Netherlands"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Kruyt", 
            "givenName": "Frank A. E.", 
            "id": "sg:person.01120677430.45", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01120677430.45"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "https://doi.org/10.1101/gad.13.19.2514", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001755925"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/1535-7163.mct-07-0167", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002663842"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.bjc.6605021", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002752800", 
              "https://doi.org/10.1038/sj.bjc.6605021"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.bjc.6605021", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002752800", 
              "https://doi.org/10.1038/sj.bjc.6605021"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1074/jbc.272.18.12116", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006801642"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1242/jcs.109587", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009679793"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.bbapap.2009.11.002", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011024498"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1074/jbc.m509560200", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011660549"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1074/jbc.m509560200", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011660549"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1152/ajpgi.00242.2005", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012380727"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrc2465", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014145135", 
              "https://doi.org/10.1038/nrc2465"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.drup.2009.11.001", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015250127"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nchembio.83", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019019383", 
              "https://doi.org/10.1038/nchembio.83"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1161/01.cir.0000062702.60708.c4", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019426550"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0014-5793(00)01212-6", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021183593"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.cgt.7700749", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021591007", 
              "https://doi.org/10.1038/sj.cgt.7700749"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.cgt.7700749", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021591007", 
              "https://doi.org/10.1038/sj.cgt.7700749"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1200/jco.2007.12.6581", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026420200"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cell.2005.06.009", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026656555"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.febslet.2006.11.004", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026878157"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/cdd.2010.9", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030046114", 
              "https://doi.org/10.1038/cdd.2010.9"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/cdd.2010.9", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030046114", 
              "https://doi.org/10.1038/cdd.2010.9"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1371/journal.pone.0005282", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031537964"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0969-2126(98)00113-0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031629988"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1128/mmbr.00031-10", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033941697"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.251194298", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035154407"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1053/j.gastro.2010.02.046", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035460257"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/jnci/djq179", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038125928"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.biocel.2007.02.007", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038659662"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/cdd.2008.63", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039698007", 
              "https://doi.org/10.1038/cdd.2008.63"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.febslet.2010.05.061", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040017329"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.onc.1207692", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040174526", 
              "https://doi.org/10.1038/sj.onc.1207692"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.3322/caac.20073", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042069193"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/onc.2010.221", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043860701", 
              "https://doi.org/10.1038/onc.2010.221"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/onc.2010.221", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043860701", 
              "https://doi.org/10.1038/onc.2010.221"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s1535-6108(02)00122-8", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044016017"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.cgt.7700792", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044033045", 
              "https://doi.org/10.1038/sj.cgt.7700792"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.cgt.7700792", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044033045", 
              "https://doi.org/10.1038/sj.cgt.7700792"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1053/j.gastro.2008.12.064", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044387532"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.cdd.4402085", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044942204", 
              "https://doi.org/10.1038/sj.cdd.4402085"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.cdd.4402085", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044942204", 
              "https://doi.org/10.1038/sj.cdd.4402085"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1074/jbc.m411657200", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045440352"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/bjc.2011.400", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046093428", 
              "https://doi.org/10.1038/bjc.2011.400"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/978-1-59745-542-8_51", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046857021", 
              "https://doi.org/10.1007/978-1-59745-542-8_51"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/978-1-59745-542-8_51", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046857021", 
              "https://doi.org/10.1007/978-1-59745-542-8_51"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00018-008-8170-7", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048040543", 
              "https://doi.org/10.1007/s00018-008-8170-7"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/hep.1840360627", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048873232"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.onc.1206427", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050315555", 
              "https://doi.org/10.1038/sj.onc.1206427"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.onc.1206427", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050315555", 
              "https://doi.org/10.1038/sj.onc.1206427"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1172/jci27726", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051842694"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1128/mcb.20.18.6638-6645.2000", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1053608058"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1074750479", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1076837996", 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2013-07", 
        "datePublishedReg": "2013-07-01", 
        "description": "Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) can induce both caspase-dependent apoptosis and kinase activation in tumor cells. Here, we examined the consequences and mechanisms of TRAIL-induced MAPKs p38 and JNK in non-small cell lung cancer (NSCLC) cells. In apoptosis sensitive H460 cells, these kinases were phosphorylated, but not in resistant A549 cells. Time course experiments in H460 cells showed that induction of p38 phosphorylation preceded that of JNK. To explore the function of these kinases in apoptosis activation by TRAIL, chemical inhibitors or siRNAs were employed to impair JNK or p38 functioning. JNK activation counteracted TRAIL-induced apoptosis whereas activation of p38 stimulated apoptosis. Notably, the serine/threonine kinase RIP1 was cleaved following TRAIL treatment, concomitant with detectable JNK phosphorylation. Further examination of the role of RIP1 by short hairpin (sh)RNA-dependent knockdown or inhibition by necrostatin-1 showed that p38 can be phosphorylated in both RIP1-dependent and -independent manner, whereas JNK phosphorylation occurred independent of RIP1. On the other hand JNK appeared to suppress RIP1 cleavage via an unknown mechanism. In addition, only the activation of JNK by TRAIL was caspase-8-dependent. Finally, we identified Mcl-1, a known substrate for p38 and JNK, as a downstream modulator of JNK or p38 activity. Collectively, our data suggest in a subset of NSCLC cells a model in which TRAIL-induced activation of p38 and JNK have counteracting effects on Mcl-1 expression leading to pro- or anti-apoptotic effects, respectively. Strategies aiming to stimulate p38 and inhibit JNK may have benefit for TRAIL-based therapies in NSCLC.", 
        "genre": "research_article", 
        "id": "sg:pub.10.1007/s10495-013-0829-3", 
        "inLanguage": [
          "en"
        ], 
        "isAccessibleForFree": false, 
        "isPartOf": [
          {
            "id": "sg:journal.1117236", 
            "issn": [
              "1360-8185", 
              "1573-675X"
            ], 
            "name": "Apoptosis", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "7", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "18"
          }
        ], 
        "name": "MAPK p38 and JNK have opposing activities on TRAIL-induced apoptosis activation in NSCLC H460 cells that involves RIP1 and caspase-8 and is mediated by Mcl-1", 
        "pagination": "851-860", 
        "productId": [
          {
            "name": "readcube_id", 
            "type": "PropertyValue", 
            "value": [
              "22b93adec6c40040f26250fec2f23239e0307541d04bc800ac2c6ecabbacf421"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "23456625"
            ]
          }, 
          {
            "name": "nlm_unique_id", 
            "type": "PropertyValue", 
            "value": [
              "9712129"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1007/s10495-013-0829-3"
            ]
          }, 
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1007289907"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1007/s10495-013-0829-3", 
          "https://app.dimensions.ai/details/publication/pub.1007289907"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2019-04-10T19:08", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8678_00000510.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "http://link.springer.com/10.1007%2Fs10495-013-0829-3"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s10495-013-0829-3'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s10495-013-0829-3'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s10495-013-0829-3'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s10495-013-0829-3'


     

    This table displays all metadata directly associated to this object as RDF triples.

    356 TRIPLES      21 PREDICATES      95 URIs      43 LITERALS      31 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1007/s10495-013-0829-3 schema:about N10054a40623e4ffaa8a7aa065c72c01b
    2 N15c13dc13dd14fb0a0b010861614d906
    3 N16e836f696a9453cbb62238ceae4d6c9
    4 N2a9bde3933ee4222a528ace121629424
    5 N3570e18b6fa34f28bd56c679cce36932
    6 N42438ae1e90547f080fce371bdeaf626
    7 N4ea11ca426c54a1c9f03601d43794530
    8 N4f0218c6b8b44daf82fb454f78aecc7d
    9 N5823a5abc8884d5a83bb222fcedd65de
    10 N74b100505813401aafae3e498e7bb69d
    11 N835e976bf2534bbe868b75c8e888af0b
    12 N845791494c5b4c5f8f7a3be52bcdbe64
    13 N9601ce15afeb4bf884a796105c0a7ed0
    14 N99b176be1f1549be9eae036132b75aae
    15 Naeacdf74cac646aa9a8edda627984904
    16 Nb8ad7983c7364a97984c2f372b0f2444
    17 Nbf5ddaabf7f84195a99e2f254b45bd1b
    18 Nc48512c3c8f74c3faf8882af14e9bf67
    19 Nd36fbf88fff84f4393a397d27096dd91
    20 Nd3eb4a01d2c64243ae73c03fe4aed8e6
    21 Nde86c23766464a418f10581b4c93201a
    22 Nf054753e5c804fbeb7d9c891e4d3b6c6
    23 anzsrc-for:06
    24 anzsrc-for:0601
    25 schema:author N59464bf3ffc0484baa2928aadb97cf72
    26 schema:citation sg:pub.10.1007/978-1-59745-542-8_51
    27 sg:pub.10.1007/s00018-008-8170-7
    28 sg:pub.10.1038/bjc.2011.400
    29 sg:pub.10.1038/cdd.2008.63
    30 sg:pub.10.1038/cdd.2010.9
    31 sg:pub.10.1038/nchembio.83
    32 sg:pub.10.1038/nrc2465
    33 sg:pub.10.1038/onc.2010.221
    34 sg:pub.10.1038/sj.bjc.6605021
    35 sg:pub.10.1038/sj.cdd.4402085
    36 sg:pub.10.1038/sj.cgt.7700749
    37 sg:pub.10.1038/sj.cgt.7700792
    38 sg:pub.10.1038/sj.onc.1206427
    39 sg:pub.10.1038/sj.onc.1207692
    40 https://app.dimensions.ai/details/publication/pub.1074750479
    41 https://app.dimensions.ai/details/publication/pub.1076837996
    42 https://doi.org/10.1002/hep.1840360627
    43 https://doi.org/10.1016/j.bbapap.2009.11.002
    44 https://doi.org/10.1016/j.biocel.2007.02.007
    45 https://doi.org/10.1016/j.cell.2005.06.009
    46 https://doi.org/10.1016/j.drup.2009.11.001
    47 https://doi.org/10.1016/j.febslet.2006.11.004
    48 https://doi.org/10.1016/j.febslet.2010.05.061
    49 https://doi.org/10.1016/s0014-5793(00)01212-6
    50 https://doi.org/10.1016/s0969-2126(98)00113-0
    51 https://doi.org/10.1016/s1535-6108(02)00122-8
    52 https://doi.org/10.1053/j.gastro.2008.12.064
    53 https://doi.org/10.1053/j.gastro.2010.02.046
    54 https://doi.org/10.1073/pnas.251194298
    55 https://doi.org/10.1074/jbc.272.18.12116
    56 https://doi.org/10.1074/jbc.m411657200
    57 https://doi.org/10.1074/jbc.m509560200
    58 https://doi.org/10.1093/jnci/djq179
    59 https://doi.org/10.1101/gad.13.19.2514
    60 https://doi.org/10.1128/mcb.20.18.6638-6645.2000
    61 https://doi.org/10.1128/mmbr.00031-10
    62 https://doi.org/10.1152/ajpgi.00242.2005
    63 https://doi.org/10.1158/1535-7163.mct-07-0167
    64 https://doi.org/10.1161/01.cir.0000062702.60708.c4
    65 https://doi.org/10.1172/jci27726
    66 https://doi.org/10.1200/jco.2007.12.6581
    67 https://doi.org/10.1242/jcs.109587
    68 https://doi.org/10.1371/journal.pone.0005282
    69 https://doi.org/10.3322/caac.20073
    70 schema:datePublished 2013-07
    71 schema:datePublishedReg 2013-07-01
    72 schema:description Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) can induce both caspase-dependent apoptosis and kinase activation in tumor cells. Here, we examined the consequences and mechanisms of TRAIL-induced MAPKs p38 and JNK in non-small cell lung cancer (NSCLC) cells. In apoptosis sensitive H460 cells, these kinases were phosphorylated, but not in resistant A549 cells. Time course experiments in H460 cells showed that induction of p38 phosphorylation preceded that of JNK. To explore the function of these kinases in apoptosis activation by TRAIL, chemical inhibitors or siRNAs were employed to impair JNK or p38 functioning. JNK activation counteracted TRAIL-induced apoptosis whereas activation of p38 stimulated apoptosis. Notably, the serine/threonine kinase RIP1 was cleaved following TRAIL treatment, concomitant with detectable JNK phosphorylation. Further examination of the role of RIP1 by short hairpin (sh)RNA-dependent knockdown or inhibition by necrostatin-1 showed that p38 can be phosphorylated in both RIP1-dependent and -independent manner, whereas JNK phosphorylation occurred independent of RIP1. On the other hand JNK appeared to suppress RIP1 cleavage via an unknown mechanism. In addition, only the activation of JNK by TRAIL was caspase-8-dependent. Finally, we identified Mcl-1, a known substrate for p38 and JNK, as a downstream modulator of JNK or p38 activity. Collectively, our data suggest in a subset of NSCLC cells a model in which TRAIL-induced activation of p38 and JNK have counteracting effects on Mcl-1 expression leading to pro- or anti-apoptotic effects, respectively. Strategies aiming to stimulate p38 and inhibit JNK may have benefit for TRAIL-based therapies in NSCLC.
    73 schema:genre research_article
    74 schema:inLanguage en
    75 schema:isAccessibleForFree false
    76 schema:isPartOf Nd095f9fb6dab4a26ac634b1d3ae9e446
    77 Nd72522ff53154b48ad90312261a1b275
    78 sg:journal.1117236
    79 schema:name MAPK p38 and JNK have opposing activities on TRAIL-induced apoptosis activation in NSCLC H460 cells that involves RIP1 and caspase-8 and is mediated by Mcl-1
    80 schema:pagination 851-860
    81 schema:productId N301c979b4fce428eb47c6d89fc93087c
    82 N3827d32c46b74c4c902dcc28f4c0d19e
    83 N81c02a76b10e4a748e9113c8daad4f4c
    84 N8a4d74c669d543d39de3b5b5c85e63e5
    85 Nf4b14abcec2543dabb6c971672bb09d1
    86 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007289907
    87 https://doi.org/10.1007/s10495-013-0829-3
    88 schema:sdDatePublished 2019-04-10T19:08
    89 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    90 schema:sdPublisher N0c38d1ccc6bd4460bdd384c8daaf8639
    91 schema:url http://link.springer.com/10.1007%2Fs10495-013-0829-3
    92 sgo:license sg:explorer/license/
    93 sgo:sdDataset articles
    94 rdf:type schema:ScholarlyArticle
    95 N0c38d1ccc6bd4460bdd384c8daaf8639 schema:name Springer Nature - SN SciGraph project
    96 rdf:type schema:Organization
    97 N10054a40623e4ffaa8a7aa065c72c01b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    98 schema:name Apoptosis
    99 rdf:type schema:DefinedTerm
    100 N15c13dc13dd14fb0a0b010861614d906 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    101 schema:name TNF-Related Apoptosis-Inducing Ligand
    102 rdf:type schema:DefinedTerm
    103 N16e836f696a9453cbb62238ceae4d6c9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    104 schema:name Phosphorylation
    105 rdf:type schema:DefinedTerm
    106 N2a9bde3933ee4222a528ace121629424 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    107 schema:name Carcinoma, Non-Small-Cell Lung
    108 rdf:type schema:DefinedTerm
    109 N301c979b4fce428eb47c6d89fc93087c schema:name doi
    110 schema:value 10.1007/s10495-013-0829-3
    111 rdf:type schema:PropertyValue
    112 N3570e18b6fa34f28bd56c679cce36932 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    113 schema:name Drug Resistance, Neoplasm
    114 rdf:type schema:DefinedTerm
    115 N3827d32c46b74c4c902dcc28f4c0d19e schema:name pubmed_id
    116 schema:value 23456625
    117 rdf:type schema:PropertyValue
    118 N42438ae1e90547f080fce371bdeaf626 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    119 schema:name p38 Mitogen-Activated Protein Kinases
    120 rdf:type schema:DefinedTerm
    121 N4ea11ca426c54a1c9f03601d43794530 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    122 schema:name Nuclear Pore Complex Proteins
    123 rdf:type schema:DefinedTerm
    124 N4f0218c6b8b44daf82fb454f78aecc7d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    125 schema:name RNA, Small Interfering
    126 rdf:type schema:DefinedTerm
    127 N4f2423b930ef49d59a1de936e031acfc rdf:first sg:person.01120677430.45
    128 rdf:rest rdf:nil
    129 N5823a5abc8884d5a83bb222fcedd65de schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    130 schema:name Cell Line, Tumor
    131 rdf:type schema:DefinedTerm
    132 N59464bf3ffc0484baa2928aadb97cf72 rdf:first sg:person.01313446176.81
    133 rdf:rest N9be46a7906f24068a4bd7aaa31d1f355
    134 N5a943e88496b42efa6c326e8fab4e1f0 rdf:first sg:person.0604510331.42
    135 rdf:rest N82650b975b544a2da0c48aa01f140c3e
    136 N689186cc8fb040258c5d45a17ccbf7d9 schema:affiliation https://www.grid.ac/institutes/grid.16872.3a
    137 schema:familyName Flach
    138 schema:givenName Koen
    139 rdf:type schema:Person
    140 N74b100505813401aafae3e498e7bb69d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    141 schema:name MAP Kinase Kinase 4
    142 rdf:type schema:DefinedTerm
    143 N80ed4a14e31648329d311539bf3328da rdf:first sg:person.0577505063.56
    144 rdf:rest Ndc52f3f93b75422d8844f9b9fa6c4c7f
    145 N81c02a76b10e4a748e9113c8daad4f4c schema:name nlm_unique_id
    146 schema:value 9712129
    147 rdf:type schema:PropertyValue
    148 N82650b975b544a2da0c48aa01f140c3e rdf:first N689186cc8fb040258c5d45a17ccbf7d9
    149 rdf:rest N80ed4a14e31648329d311539bf3328da
    150 N835e976bf2534bbe868b75c8e888af0b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    151 schema:name RNA-Binding Proteins
    152 rdf:type schema:DefinedTerm
    153 N845791494c5b4c5f8f7a3be52bcdbe64 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    154 schema:name Cell Proliferation
    155 rdf:type schema:DefinedTerm
    156 N8a4d74c669d543d39de3b5b5c85e63e5 schema:name dimensions_id
    157 schema:value pub.1007289907
    158 rdf:type schema:PropertyValue
    159 N9601ce15afeb4bf884a796105c0a7ed0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    160 schema:name Proteolysis
    161 rdf:type schema:DefinedTerm
    162 N99b176be1f1549be9eae036132b75aae schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    163 schema:name Caspase 8
    164 rdf:type schema:DefinedTerm
    165 N9be46a7906f24068a4bd7aaa31d1f355 rdf:first sg:person.0652615675.63
    166 rdf:rest N5a943e88496b42efa6c326e8fab4e1f0
    167 Naeacdf74cac646aa9a8edda627984904 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    168 schema:name Gene Expression Regulation, Neoplastic
    169 rdf:type schema:DefinedTerm
    170 Nb8ad7983c7364a97984c2f372b0f2444 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    171 schema:name Lung Neoplasms
    172 rdf:type schema:DefinedTerm
    173 Nbf5ddaabf7f84195a99e2f254b45bd1b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    174 schema:name Signal Transduction
    175 rdf:type schema:DefinedTerm
    176 Nc48512c3c8f74c3faf8882af14e9bf67 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    177 schema:name Indoles
    178 rdf:type schema:DefinedTerm
    179 Nd095f9fb6dab4a26ac634b1d3ae9e446 schema:volumeNumber 18
    180 rdf:type schema:PublicationVolume
    181 Nd36fbf88fff84f4393a397d27096dd91 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    182 schema:name Imidazoles
    183 rdf:type schema:DefinedTerm
    184 Nd3eb4a01d2c64243ae73c03fe4aed8e6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    185 schema:name Humans
    186 rdf:type schema:DefinedTerm
    187 Nd72522ff53154b48ad90312261a1b275 schema:issueNumber 7
    188 rdf:type schema:PublicationIssue
    189 Ndc52f3f93b75422d8844f9b9fa6c4c7f rdf:first sg:person.01255301342.17
    190 rdf:rest Nf1cb88db5f0547bab86aa259e80e2bff
    191 Nde86c23766464a418f10581b4c93201a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    192 schema:name Myeloid Cell Leukemia Sequence 1 Protein
    193 rdf:type schema:DefinedTerm
    194 Nf054753e5c804fbeb7d9c891e4d3b6c6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    195 schema:name Organ Specificity
    196 rdf:type schema:DefinedTerm
    197 Nf1cb88db5f0547bab86aa259e80e2bff rdf:first sg:person.0701617307.93
    198 rdf:rest N4f2423b930ef49d59a1de936e031acfc
    199 Nf4b14abcec2543dabb6c971672bb09d1 schema:name readcube_id
    200 schema:value 22b93adec6c40040f26250fec2f23239e0307541d04bc800ac2c6ecabbacf421
    201 rdf:type schema:PropertyValue
    202 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
    203 schema:name Biological Sciences
    204 rdf:type schema:DefinedTerm
    205 anzsrc-for:0601 schema:inDefinedTermSet anzsrc-for:
    206 schema:name Biochemistry and Cell Biology
    207 rdf:type schema:DefinedTerm
    208 sg:journal.1117236 schema:issn 1360-8185
    209 1573-675X
    210 schema:name Apoptosis
    211 rdf:type schema:Periodical
    212 sg:person.01120677430.45 schema:affiliation https://www.grid.ac/institutes/grid.4494.d
    213 schema:familyName Kruyt
    214 schema:givenName Frank A. E.
    215 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01120677430.45
    216 rdf:type schema:Person
    217 sg:person.01255301342.17 schema:affiliation https://www.grid.ac/institutes/grid.16872.3a
    218 schema:familyName Peters
    219 schema:givenName Godefridus J.
    220 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01255301342.17
    221 rdf:type schema:Person
    222 sg:person.01313446176.81 schema:affiliation https://www.grid.ac/institutes/grid.16872.3a
    223 schema:familyName Azijli
    224 schema:givenName Kaamar
    225 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01313446176.81
    226 rdf:type schema:Person
    227 sg:person.0577505063.56 schema:affiliation https://www.grid.ac/institutes/grid.16872.3a
    228 schema:familyName Giovannetti
    229 schema:givenName Elisa
    230 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0577505063.56
    231 rdf:type schema:Person
    232 sg:person.0604510331.42 schema:affiliation https://www.grid.ac/institutes/grid.4830.f
    233 schema:familyName van Roosmalen
    234 schema:givenName Ingrid
    235 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0604510331.42
    236 rdf:type schema:Person
    237 sg:person.0652615675.63 schema:affiliation https://www.grid.ac/institutes/grid.4494.d
    238 schema:familyName Yuvaraj
    239 schema:givenName Saravanan
    240 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0652615675.63
    241 rdf:type schema:Person
    242 sg:person.0701617307.93 schema:affiliation https://www.grid.ac/institutes/grid.4494.d
    243 schema:familyName de Jong
    244 schema:givenName Steven
    245 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0701617307.93
    246 rdf:type schema:Person
    247 sg:pub.10.1007/978-1-59745-542-8_51 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046857021
    248 https://doi.org/10.1007/978-1-59745-542-8_51
    249 rdf:type schema:CreativeWork
    250 sg:pub.10.1007/s00018-008-8170-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048040543
    251 https://doi.org/10.1007/s00018-008-8170-7
    252 rdf:type schema:CreativeWork
    253 sg:pub.10.1038/bjc.2011.400 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046093428
    254 https://doi.org/10.1038/bjc.2011.400
    255 rdf:type schema:CreativeWork
    256 sg:pub.10.1038/cdd.2008.63 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039698007
    257 https://doi.org/10.1038/cdd.2008.63
    258 rdf:type schema:CreativeWork
    259 sg:pub.10.1038/cdd.2010.9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030046114
    260 https://doi.org/10.1038/cdd.2010.9
    261 rdf:type schema:CreativeWork
    262 sg:pub.10.1038/nchembio.83 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019019383
    263 https://doi.org/10.1038/nchembio.83
    264 rdf:type schema:CreativeWork
    265 sg:pub.10.1038/nrc2465 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014145135
    266 https://doi.org/10.1038/nrc2465
    267 rdf:type schema:CreativeWork
    268 sg:pub.10.1038/onc.2010.221 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043860701
    269 https://doi.org/10.1038/onc.2010.221
    270 rdf:type schema:CreativeWork
    271 sg:pub.10.1038/sj.bjc.6605021 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002752800
    272 https://doi.org/10.1038/sj.bjc.6605021
    273 rdf:type schema:CreativeWork
    274 sg:pub.10.1038/sj.cdd.4402085 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044942204
    275 https://doi.org/10.1038/sj.cdd.4402085
    276 rdf:type schema:CreativeWork
    277 sg:pub.10.1038/sj.cgt.7700749 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021591007
    278 https://doi.org/10.1038/sj.cgt.7700749
    279 rdf:type schema:CreativeWork
    280 sg:pub.10.1038/sj.cgt.7700792 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044033045
    281 https://doi.org/10.1038/sj.cgt.7700792
    282 rdf:type schema:CreativeWork
    283 sg:pub.10.1038/sj.onc.1206427 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050315555
    284 https://doi.org/10.1038/sj.onc.1206427
    285 rdf:type schema:CreativeWork
    286 sg:pub.10.1038/sj.onc.1207692 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040174526
    287 https://doi.org/10.1038/sj.onc.1207692
    288 rdf:type schema:CreativeWork
    289 https://app.dimensions.ai/details/publication/pub.1074750479 schema:CreativeWork
    290 https://app.dimensions.ai/details/publication/pub.1076837996 schema:CreativeWork
    291 https://doi.org/10.1002/hep.1840360627 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048873232
    292 rdf:type schema:CreativeWork
    293 https://doi.org/10.1016/j.bbapap.2009.11.002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011024498
    294 rdf:type schema:CreativeWork
    295 https://doi.org/10.1016/j.biocel.2007.02.007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038659662
    296 rdf:type schema:CreativeWork
    297 https://doi.org/10.1016/j.cell.2005.06.009 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026656555
    298 rdf:type schema:CreativeWork
    299 https://doi.org/10.1016/j.drup.2009.11.001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015250127
    300 rdf:type schema:CreativeWork
    301 https://doi.org/10.1016/j.febslet.2006.11.004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026878157
    302 rdf:type schema:CreativeWork
    303 https://doi.org/10.1016/j.febslet.2010.05.061 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040017329
    304 rdf:type schema:CreativeWork
    305 https://doi.org/10.1016/s0014-5793(00)01212-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021183593
    306 rdf:type schema:CreativeWork
    307 https://doi.org/10.1016/s0969-2126(98)00113-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031629988
    308 rdf:type schema:CreativeWork
    309 https://doi.org/10.1016/s1535-6108(02)00122-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044016017
    310 rdf:type schema:CreativeWork
    311 https://doi.org/10.1053/j.gastro.2008.12.064 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044387532
    312 rdf:type schema:CreativeWork
    313 https://doi.org/10.1053/j.gastro.2010.02.046 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035460257
    314 rdf:type schema:CreativeWork
    315 https://doi.org/10.1073/pnas.251194298 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035154407
    316 rdf:type schema:CreativeWork
    317 https://doi.org/10.1074/jbc.272.18.12116 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006801642
    318 rdf:type schema:CreativeWork
    319 https://doi.org/10.1074/jbc.m411657200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045440352
    320 rdf:type schema:CreativeWork
    321 https://doi.org/10.1074/jbc.m509560200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011660549
    322 rdf:type schema:CreativeWork
    323 https://doi.org/10.1093/jnci/djq179 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038125928
    324 rdf:type schema:CreativeWork
    325 https://doi.org/10.1101/gad.13.19.2514 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001755925
    326 rdf:type schema:CreativeWork
    327 https://doi.org/10.1128/mcb.20.18.6638-6645.2000 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053608058
    328 rdf:type schema:CreativeWork
    329 https://doi.org/10.1128/mmbr.00031-10 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033941697
    330 rdf:type schema:CreativeWork
    331 https://doi.org/10.1152/ajpgi.00242.2005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012380727
    332 rdf:type schema:CreativeWork
    333 https://doi.org/10.1158/1535-7163.mct-07-0167 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002663842
    334 rdf:type schema:CreativeWork
    335 https://doi.org/10.1161/01.cir.0000062702.60708.c4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019426550
    336 rdf:type schema:CreativeWork
    337 https://doi.org/10.1172/jci27726 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051842694
    338 rdf:type schema:CreativeWork
    339 https://doi.org/10.1200/jco.2007.12.6581 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026420200
    340 rdf:type schema:CreativeWork
    341 https://doi.org/10.1242/jcs.109587 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009679793
    342 rdf:type schema:CreativeWork
    343 https://doi.org/10.1371/journal.pone.0005282 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031537964
    344 rdf:type schema:CreativeWork
    345 https://doi.org/10.3322/caac.20073 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042069193
    346 rdf:type schema:CreativeWork
    347 https://www.grid.ac/institutes/grid.16872.3a schema:alternateName VU University Medical Center
    348 schema:name Department of Medical Oncology, University of Groningen, University Medical Center Groningen, Hanzeplein 1, 9713 GZ, Groningen, The Netherlands
    349 Department of Medical Oncology, VU University Medical Center, Amsterdam, The Netherlands
    350 rdf:type schema:Organization
    351 https://www.grid.ac/institutes/grid.4494.d schema:alternateName University Medical Center Groningen
    352 schema:name Department of Medical Oncology, University of Groningen, University Medical Center Groningen, Hanzeplein 1, 9713 GZ, Groningen, The Netherlands
    353 rdf:type schema:Organization
    354 https://www.grid.ac/institutes/grid.4830.f schema:alternateName University of Groningen
    355 schema:name Department of Pharmaceutical Biology, University of Groningen, Groningen, The Netherlands
    356 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...