Targeting Chk2 improves gastric cancer chemotherapy by impairing DNA damage repair View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2013-03

AUTHORS

A. Gutiérrez-González, C. Belda-Iniesta, J. Bargiela-Iparraguirre, G. Dominguez, P. García Alfonso, R. Perona, I. Sanchez-Perez

ABSTRACT

Our results demonstrate that the addition of cisplatin after paclitaxel-induced mitotic arrest was more effective than individual treatment on gastric adenocarcinoma cells (MKN45). However, the treatment did not induce benefits in cells derived from lymph node metastasis (ST2957). Time-lapse microscopy revealed that cell death was caused by mitotic catastrophe and apoptosis induction, as the use of the caspase inhibitor z-VAD-fmk decreased cell death. We propose that the molecular mechanism mediating this cell fate is a slippage suffered by these cells, given that our Western blot (WB) analysis revealed premature cyclin B degradation. This resulted in the cell exiting from mitosis without undergoing DNA damage repair, as demonstrated by the strong phosphorylation of H2AX. A comet assay indicated that DNA repair was impaired, and Western blotting showed that the Chk2 protein was degraded after sequential treatment (paclitaxel-cisplatin). Based on these results, the modulation of cell death during mitosis may be an effective strategy for gastric cancer therapy. More... »

PAGES

347-360

References to SciGraph publications

  • 2008-02. Diagnosing and exploiting cancer's addiction to blocks in apoptosis in NATURE REVIEWS CANCER
  • 2009-10. The DNA-damage response in human biology and disease in NATURE
  • 2008-02. A phase II study of paclitaxel combined with infusional 5-fluorouracil and low-dose leucovorin for advanced gastric cancer in CANCER CHEMOTHERAPY AND PHARMACOLOGY
  • 2010-05. The CHK2–BRCA1 tumour suppressor pathway ensures chromosomal stability in human somatic cells in NATURE CELL BIOLOGY
  • 1993-12. Characterization of four new gastric cancer cell lines in VIRCHOWS ARCHIV B CELL PATHOLOGY
  • 2011-12. A multicenter, phase II study of Bortezomib (PS-341) in patients with unresectable or metastatic gastric and gastroesophageal junction adenocarcinoma in INVESTIGATIONAL NEW DRUGS
  • 2011-06. Mitotic catastrophe: a mechanism for avoiding genomic instability in NATURE REVIEWS MOLECULAR CELL BIOLOGY
  • 2011-10. Cost-effectiveness analysis of trastuzumab to treat HER2-positive advanced gastric cancer based on the randomised ToGA trial in BRITISH JOURNAL OF CANCER
  • 2007-12. CHK2 kinase: cancer susceptibility and cancer therapy – two sides of the same coin? in NATURE REVIEWS CANCER
  • 2010-05. A mitotic role for the DNA damage-responsive CHK2 kinase in NATURE CELL BIOLOGY
  • 2011-10. Phase II study of weekly paclitaxel, cisplatin, and 5-fluorouracil for advanced gastric cancer in GASTRIC CANCER
  • 2004-11. Cell-cycle checkpoints and cancer in NATURE
  • 2012-01-18. DNA breaks and chromosome pulverization from errors in mitosis in NATURE
  • 2012-07. Efficacy of trastuzumab in Japanese patients with HER2-positive advanced gastric or gastroesophageal junction cancer: a subgroup analysis of the Trastuzumab for Gastric Cancer (ToGA) study in GASTRIC CANCER
  • 2012-04. A telomere-dependent DNA damage checkpoint induced by prolonged mitotic arrest in NATURE STRUCTURAL & MOLECULAR BIOLOGY
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/s10495-012-0794-2

    DOI

    http://dx.doi.org/10.1007/s10495-012-0794-2

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1037861340

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/23271172


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0601", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Biochemistry and Cell Biology", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Biological Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Amino Acid Chloromethyl Ketones", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Antineoplastic Combined Chemotherapy Protocols", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Apoptosis", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Cell Line, Tumor", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Checkpoint Kinase 2", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Cisplatin", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Cyclin B", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "DNA Repair", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Humans", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Lymphatic Metastasis", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Mitosis", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Paclitaxel", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Protein-Serine-Threonine Kinases", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Stomach Neoplasms", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Taxoids", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "Spanish National Research Council", 
              "id": "https://www.grid.ac/institutes/grid.4711.3", 
              "name": [
                "Department of Biochemistry, School of Medicine, UAM, Madrid, Spain", 
                "Biomedical Research Institute of Madrid, Madrid CSIC/UAM, C/Arturo Duperier 4, 28029, Madrid, Spain"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Guti\u00e9rrez-Gonz\u00e1lez", 
            "givenName": "A.", 
            "id": "sg:person.01154135402.43", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01154135402.43"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Hospital Universitario La Paz", 
              "id": "https://www.grid.ac/institutes/grid.81821.32", 
              "name": [
                "Thoracic, Head & Neck and Brain Oncology Unit, CIOCC Centro integral Oncol\u00f3gico Clara Campal. GHM Grupo Hospital de Madrid, Madrid, Spain", 
                "Biomarkers and Experimental Therapeutics Group, IdiPAZ, University Hospital La Paz, Madrid, Spain"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Belda-Iniesta", 
            "givenName": "C.", 
            "id": "sg:person.01270217230.39", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01270217230.39"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Spanish National Research Council", 
              "id": "https://www.grid.ac/institutes/grid.4711.3", 
              "name": [
                "Department of Biochemistry, School of Medicine, UAM, Madrid, Spain", 
                "Biomedical Research Institute of Madrid, Madrid CSIC/UAM, C/Arturo Duperier 4, 28029, Madrid, Spain"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Bargiela-Iparraguirre", 
            "givenName": "J.", 
            "id": "sg:person.01270364002.34", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01270364002.34"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Hospital Universitario Puerta de Hierro Majadahonda", 
              "id": "https://www.grid.ac/institutes/grid.73221.35", 
              "name": [
                "Department of Medical Oncology, University Hospital Puerta de Hierro, UAM, Madrid, Spain"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Dominguez", 
            "givenName": "G.", 
            "id": "sg:person.01166154641.35", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01166154641.35"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Hospital General Universitario Gregorio Mara\u00f1\u00f3n", 
              "id": "https://www.grid.ac/institutes/grid.410526.4", 
              "name": [
                "Department of Medical Oncology, Gregorio Mara\u00f1on Hospital, Madrid, Spain"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Garc\u00eda Alfonso", 
            "givenName": "P.", 
            "id": "sg:person.013205147567.38", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013205147567.38"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Hospital Universitario La Paz", 
              "id": "https://www.grid.ac/institutes/grid.81821.32", 
              "name": [
                "Biomedical Research Institute of Madrid, Madrid CSIC/UAM, C/Arturo Duperier 4, 28029, Madrid, Spain", 
                "Biomarkers and Experimental Therapeutics Group, IdiPAZ, University Hospital La Paz, Madrid, Spain", 
                "CIBER on Rare Diseases (CIBERER), Valencia, Spain"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Perona", 
            "givenName": "R.", 
            "id": "sg:person.01265024146.68", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01265024146.68"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Spanish National Research Council", 
              "id": "https://www.grid.ac/institutes/grid.4711.3", 
              "name": [
                "Department of Biochemistry, School of Medicine, UAM, Madrid, Spain", 
                "Biomedical Research Institute of Madrid, Madrid CSIC/UAM, C/Arturo Duperier 4, 28029, Madrid, Spain"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Sanchez-Perez", 
            "givenName": "I.", 
            "id": "sg:person.01145643313.69", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01145643313.69"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "https://doi.org/10.1158/1078-0432.ccr-10-1215", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000573421"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/bf02899281", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005367300", 
              "https://doi.org/10.1007/bf02899281"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/bf02899281", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005367300", 
              "https://doi.org/10.1007/bf02899281"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/ijc.26292", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006293373"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1038/embor.2011.62", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007430735"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature10802", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008061452", 
              "https://doi.org/10.1038/nature10802"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1001/jama.2010.534", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008087002"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.febslet.2010.07.057", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009333473"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.canlet.2008.08.026", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010553876"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature03097", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012054610", 
              "https://doi.org/10.1038/nature03097"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature03097", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012054610", 
              "https://doi.org/10.1038/nature03097"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/14651858.cd004064.pub3", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012727308"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/14651858.cd004064.pub3", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012727308"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1074/jbc.m208685200", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014698192"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1371/journal.pone.0015724", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016691440"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s10120-011-0118-1", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018206312", 
              "https://doi.org/10.1007/s10120-011-0118-1"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.mrgentox.2004.01.013", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018422732"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrm3115", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018735275", 
              "https://doi.org/10.1038/nrm3115"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/0008-5472.can-06-3095", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022304739"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/1535-7163.mct-06-0567", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022539252"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.ctrv.2010.01.005", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023167426"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.biocel.2009.11.011", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023229065"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1200/jco.2006.06.8429", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023864538"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/0008-5472.can-12-2354", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024662504"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.ccr.2009.08.020", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024694567"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.dnarep.2009.04.012", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1025189830"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nsmb.2245", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1025645333", 
              "https://doi.org/10.1038/nsmb.2245"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1038/emboj.2010.112", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026038005"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s10637-010-9474-7", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029378423", 
              "https://doi.org/10.1007/s10637-010-9474-7"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s10120-011-0043-3", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030938566", 
              "https://doi.org/10.1007/s10120-011-0043-3"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.dnarep.2004.03.033", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036174050"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0014-5793(01)02756-9", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036265029"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00280-007-0508-6", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036594365", 
              "https://doi.org/10.1007/s00280-007-0508-6"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.devcel.2004.09.002", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037134328"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1476-5381.2009.00607.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038659257"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1476-5381.2009.00607.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038659257"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.bbcan.2008.05.002", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039720493"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.molcel.2012.02.015", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040202134"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1371/journal.pgen.1001385", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040662320"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/ijc.10272", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040678393"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0014-4827(88)90265-0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041300635"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrc2297", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041493658", 
              "https://doi.org/10.1038/nrc2297"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrc2251", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044052352", 
              "https://doi.org/10.1038/nrc2251"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/1078-0432.ccr-10-2927", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044700020"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1074/jbc.c300554200", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045662235"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1083/jcb.200812045", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047183790"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s1097-2765(00)80202-6", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047827768"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/bjc.2011.390", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048865019", 
              "https://doi.org/10.1038/bjc.2011.390"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1128/mcb.24.2.708-718.2004", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050125987"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ncb2051", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050909369", 
              "https://doi.org/10.1038/ncb2051"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ncb0510-424", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051620797", 
              "https://doi.org/10.1038/ncb0510-424"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ncb0510-424", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051620797", 
              "https://doi.org/10.1038/ncb0510-424"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature08467", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052581766", 
              "https://doi.org/10.1038/nature08467"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature08467", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052581766", 
              "https://doi.org/10.1038/nature08467"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.1071398", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1062446509"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.2174/138161210789941801", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1069167154"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.4149/gpb_2012_002", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1072261625"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1077653754", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1077926254", 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2013-03", 
        "datePublishedReg": "2013-03-01", 
        "description": "Our results demonstrate that the addition of cisplatin after paclitaxel-induced mitotic arrest was more effective than individual treatment on gastric adenocarcinoma cells (MKN45). However, the treatment did not induce benefits in cells derived from lymph node metastasis (ST2957). Time-lapse microscopy revealed that cell death was caused by mitotic catastrophe and apoptosis induction, as the use of the caspase inhibitor z-VAD-fmk decreased cell death. We propose that the molecular mechanism mediating this cell fate is a slippage suffered by these cells, given that our Western blot (WB) analysis revealed premature cyclin B degradation. This resulted in the cell exiting from mitosis without undergoing DNA damage repair, as demonstrated by the strong phosphorylation of H2AX. A comet assay indicated that DNA repair was impaired, and Western blotting showed that the Chk2 protein was degraded after sequential treatment (paclitaxel-cisplatin). Based on these results, the modulation of cell death during mitosis may be an effective strategy for gastric cancer therapy.", 
        "genre": "research_article", 
        "id": "sg:pub.10.1007/s10495-012-0794-2", 
        "inLanguage": [
          "en"
        ], 
        "isAccessibleForFree": true, 
        "isPartOf": [
          {
            "id": "sg:journal.1117236", 
            "issn": [
              "1360-8185", 
              "1573-675X"
            ], 
            "name": "Apoptosis", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "3", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "18"
          }
        ], 
        "name": "Targeting Chk2 improves gastric cancer chemotherapy by impairing DNA damage repair", 
        "pagination": "347-360", 
        "productId": [
          {
            "name": "readcube_id", 
            "type": "PropertyValue", 
            "value": [
              "b45c5ba6525aade34434688d17d3f28a10c9d48be7a1549eb49c68aebe1d82bc"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "23271172"
            ]
          }, 
          {
            "name": "nlm_unique_id", 
            "type": "PropertyValue", 
            "value": [
              "9712129"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1007/s10495-012-0794-2"
            ]
          }, 
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1037861340"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1007/s10495-012-0794-2", 
          "https://app.dimensions.ai/details/publication/pub.1037861340"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2019-04-11T01:07", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8697_00000514.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "http://link.springer.com/10.1007%2Fs10495-012-0794-2"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s10495-012-0794-2'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s10495-012-0794-2'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s10495-012-0794-2'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s10495-012-0794-2'


     

    This table displays all metadata directly associated to this object as RDF triples.

    356 TRIPLES      21 PREDICATES      97 URIs      36 LITERALS      24 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1007/s10495-012-0794-2 schema:about N1508011f62cb4ca8b001da1cad6f3cae
    2 N1718eaa2af6f43c9865906b9e64d7aba
    3 N204ecf9628f941d599872672e059b754
    4 N4a0c6dba250044688fa3ab9a7c322942
    5 N54f9d9c32c254ac398a8966cddd8ff7a
    6 N5ad91c7990be46319880eac3045c7fca
    7 N6222fcccaec34fdb8d4469a64c3cf530
    8 N6ecf85b3129d430b8f33d89562bbdc6c
    9 N7fcc0e720b08479e93d946354f9afd59
    10 N8cc5a97c46494152b299b6bc4becc37e
    11 N9b43003306b5482bae991a7b5af50762
    12 Na1b3eff4a2f34ad2bfc2f87ddb41e569
    13 Nb1c8b04097514fa9b0b9e5856f3db1fd
    14 Nc9683b1d52e94b80b5d855405f166390
    15 Ne88d1a0eae344dde81a4d51c782f0f8f
    16 anzsrc-for:06
    17 anzsrc-for:0601
    18 schema:author N21ea656512d949a78830aaa0d43e8a0e
    19 schema:citation sg:pub.10.1007/bf02899281
    20 sg:pub.10.1007/s00280-007-0508-6
    21 sg:pub.10.1007/s10120-011-0043-3
    22 sg:pub.10.1007/s10120-011-0118-1
    23 sg:pub.10.1007/s10637-010-9474-7
    24 sg:pub.10.1038/bjc.2011.390
    25 sg:pub.10.1038/nature03097
    26 sg:pub.10.1038/nature08467
    27 sg:pub.10.1038/nature10802
    28 sg:pub.10.1038/ncb0510-424
    29 sg:pub.10.1038/ncb2051
    30 sg:pub.10.1038/nrc2251
    31 sg:pub.10.1038/nrc2297
    32 sg:pub.10.1038/nrm3115
    33 sg:pub.10.1038/nsmb.2245
    34 https://app.dimensions.ai/details/publication/pub.1077653754
    35 https://app.dimensions.ai/details/publication/pub.1077926254
    36 https://doi.org/10.1001/jama.2010.534
    37 https://doi.org/10.1002/14651858.cd004064.pub3
    38 https://doi.org/10.1002/ijc.10272
    39 https://doi.org/10.1002/ijc.26292
    40 https://doi.org/10.1016/0014-4827(88)90265-0
    41 https://doi.org/10.1016/j.bbcan.2008.05.002
    42 https://doi.org/10.1016/j.biocel.2009.11.011
    43 https://doi.org/10.1016/j.canlet.2008.08.026
    44 https://doi.org/10.1016/j.ccr.2009.08.020
    45 https://doi.org/10.1016/j.ctrv.2010.01.005
    46 https://doi.org/10.1016/j.devcel.2004.09.002
    47 https://doi.org/10.1016/j.dnarep.2004.03.033
    48 https://doi.org/10.1016/j.dnarep.2009.04.012
    49 https://doi.org/10.1016/j.febslet.2010.07.057
    50 https://doi.org/10.1016/j.molcel.2012.02.015
    51 https://doi.org/10.1016/j.mrgentox.2004.01.013
    52 https://doi.org/10.1016/s0014-5793(01)02756-9
    53 https://doi.org/10.1016/s1097-2765(00)80202-6
    54 https://doi.org/10.1038/emboj.2010.112
    55 https://doi.org/10.1038/embor.2011.62
    56 https://doi.org/10.1074/jbc.c300554200
    57 https://doi.org/10.1074/jbc.m208685200
    58 https://doi.org/10.1083/jcb.200812045
    59 https://doi.org/10.1111/j.1476-5381.2009.00607.x
    60 https://doi.org/10.1126/science.1071398
    61 https://doi.org/10.1128/mcb.24.2.708-718.2004
    62 https://doi.org/10.1158/0008-5472.can-06-3095
    63 https://doi.org/10.1158/0008-5472.can-12-2354
    64 https://doi.org/10.1158/1078-0432.ccr-10-1215
    65 https://doi.org/10.1158/1078-0432.ccr-10-2927
    66 https://doi.org/10.1158/1535-7163.mct-06-0567
    67 https://doi.org/10.1200/jco.2006.06.8429
    68 https://doi.org/10.1371/journal.pgen.1001385
    69 https://doi.org/10.1371/journal.pone.0015724
    70 https://doi.org/10.2174/138161210789941801
    71 https://doi.org/10.4149/gpb_2012_002
    72 schema:datePublished 2013-03
    73 schema:datePublishedReg 2013-03-01
    74 schema:description Our results demonstrate that the addition of cisplatin after paclitaxel-induced mitotic arrest was more effective than individual treatment on gastric adenocarcinoma cells (MKN45). However, the treatment did not induce benefits in cells derived from lymph node metastasis (ST2957). Time-lapse microscopy revealed that cell death was caused by mitotic catastrophe and apoptosis induction, as the use of the caspase inhibitor z-VAD-fmk decreased cell death. We propose that the molecular mechanism mediating this cell fate is a slippage suffered by these cells, given that our Western blot (WB) analysis revealed premature cyclin B degradation. This resulted in the cell exiting from mitosis without undergoing DNA damage repair, as demonstrated by the strong phosphorylation of H2AX. A comet assay indicated that DNA repair was impaired, and Western blotting showed that the Chk2 protein was degraded after sequential treatment (paclitaxel-cisplatin). Based on these results, the modulation of cell death during mitosis may be an effective strategy for gastric cancer therapy.
    75 schema:genre research_article
    76 schema:inLanguage en
    77 schema:isAccessibleForFree true
    78 schema:isPartOf N9815886a743a4c7bb3e7231d6136a078
    79 Nabde65ed56264839bced007f665c1f11
    80 sg:journal.1117236
    81 schema:name Targeting Chk2 improves gastric cancer chemotherapy by impairing DNA damage repair
    82 schema:pagination 347-360
    83 schema:productId N31e81998cd9e4b3d92b9cbb948732309
    84 N85eb69d718d141a383bdc04205ef34f4
    85 Nb2daef2f52954b3298b06b76ecf09b72
    86 Nbc6e1ff53e3c41d5a9e5d271c162367f
    87 Ncd5da02e758c4f069352cf00a28c4eef
    88 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037861340
    89 https://doi.org/10.1007/s10495-012-0794-2
    90 schema:sdDatePublished 2019-04-11T01:07
    91 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    92 schema:sdPublisher N34eeb2ff09464773b0674743193e7f28
    93 schema:url http://link.springer.com/10.1007%2Fs10495-012-0794-2
    94 sgo:license sg:explorer/license/
    95 sgo:sdDataset articles
    96 rdf:type schema:ScholarlyArticle
    97 N1508011f62cb4ca8b001da1cad6f3cae schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    98 schema:name Stomach Neoplasms
    99 rdf:type schema:DefinedTerm
    100 N1718eaa2af6f43c9865906b9e64d7aba schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    101 schema:name Amino Acid Chloromethyl Ketones
    102 rdf:type schema:DefinedTerm
    103 N204ecf9628f941d599872672e059b754 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    104 schema:name Taxoids
    105 rdf:type schema:DefinedTerm
    106 N21cee206701441f88570715ac1a23d2b rdf:first sg:person.01145643313.69
    107 rdf:rest rdf:nil
    108 N21ea656512d949a78830aaa0d43e8a0e rdf:first sg:person.01154135402.43
    109 rdf:rest N6ea97c4577404171a01fdd423ada11ba
    110 N31e81998cd9e4b3d92b9cbb948732309 schema:name readcube_id
    111 schema:value b45c5ba6525aade34434688d17d3f28a10c9d48be7a1549eb49c68aebe1d82bc
    112 rdf:type schema:PropertyValue
    113 N34eeb2ff09464773b0674743193e7f28 schema:name Springer Nature - SN SciGraph project
    114 rdf:type schema:Organization
    115 N4a0c6dba250044688fa3ab9a7c322942 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    116 schema:name Cyclin B
    117 rdf:type schema:DefinedTerm
    118 N54f9d9c32c254ac398a8966cddd8ff7a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    119 schema:name Mitosis
    120 rdf:type schema:DefinedTerm
    121 N5ad91c7990be46319880eac3045c7fca schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    122 schema:name Lymphatic Metastasis
    123 rdf:type schema:DefinedTerm
    124 N6222fcccaec34fdb8d4469a64c3cf530 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    125 schema:name Apoptosis
    126 rdf:type schema:DefinedTerm
    127 N6ea97c4577404171a01fdd423ada11ba rdf:first sg:person.01270217230.39
    128 rdf:rest Nd23bfad5d6cd4154927bd6ab33923253
    129 N6ecf85b3129d430b8f33d89562bbdc6c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    130 schema:name Cisplatin
    131 rdf:type schema:DefinedTerm
    132 N7fcc0e720b08479e93d946354f9afd59 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    133 schema:name DNA Repair
    134 rdf:type schema:DefinedTerm
    135 N85eb69d718d141a383bdc04205ef34f4 schema:name pubmed_id
    136 schema:value 23271172
    137 rdf:type schema:PropertyValue
    138 N8cc5a97c46494152b299b6bc4becc37e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    139 schema:name Antineoplastic Combined Chemotherapy Protocols
    140 rdf:type schema:DefinedTerm
    141 N932169c8f94e413dbb486efc6872a232 rdf:first sg:person.013205147567.38
    142 rdf:rest Nddf1960afd004359a68eddea759991ba
    143 N9815886a743a4c7bb3e7231d6136a078 schema:issueNumber 3
    144 rdf:type schema:PublicationIssue
    145 N9b43003306b5482bae991a7b5af50762 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    146 schema:name Humans
    147 rdf:type schema:DefinedTerm
    148 Na1b3eff4a2f34ad2bfc2f87ddb41e569 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    149 schema:name Cell Line, Tumor
    150 rdf:type schema:DefinedTerm
    151 Nabde65ed56264839bced007f665c1f11 schema:volumeNumber 18
    152 rdf:type schema:PublicationVolume
    153 Nb1c8b04097514fa9b0b9e5856f3db1fd schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    154 schema:name Protein-Serine-Threonine Kinases
    155 rdf:type schema:DefinedTerm
    156 Nb2daef2f52954b3298b06b76ecf09b72 schema:name dimensions_id
    157 schema:value pub.1037861340
    158 rdf:type schema:PropertyValue
    159 Nbc6e1ff53e3c41d5a9e5d271c162367f schema:name doi
    160 schema:value 10.1007/s10495-012-0794-2
    161 rdf:type schema:PropertyValue
    162 Nc9683b1d52e94b80b5d855405f166390 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    163 schema:name Paclitaxel
    164 rdf:type schema:DefinedTerm
    165 Ncd5da02e758c4f069352cf00a28c4eef schema:name nlm_unique_id
    166 schema:value 9712129
    167 rdf:type schema:PropertyValue
    168 Nd23bfad5d6cd4154927bd6ab33923253 rdf:first sg:person.01270364002.34
    169 rdf:rest Nfb3c18984e674f03ab19c7fd579dfbc7
    170 Nddf1960afd004359a68eddea759991ba rdf:first sg:person.01265024146.68
    171 rdf:rest N21cee206701441f88570715ac1a23d2b
    172 Ne88d1a0eae344dde81a4d51c782f0f8f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    173 schema:name Checkpoint Kinase 2
    174 rdf:type schema:DefinedTerm
    175 Nfb3c18984e674f03ab19c7fd579dfbc7 rdf:first sg:person.01166154641.35
    176 rdf:rest N932169c8f94e413dbb486efc6872a232
    177 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
    178 schema:name Biological Sciences
    179 rdf:type schema:DefinedTerm
    180 anzsrc-for:0601 schema:inDefinedTermSet anzsrc-for:
    181 schema:name Biochemistry and Cell Biology
    182 rdf:type schema:DefinedTerm
    183 sg:journal.1117236 schema:issn 1360-8185
    184 1573-675X
    185 schema:name Apoptosis
    186 rdf:type schema:Periodical
    187 sg:person.01145643313.69 schema:affiliation https://www.grid.ac/institutes/grid.4711.3
    188 schema:familyName Sanchez-Perez
    189 schema:givenName I.
    190 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01145643313.69
    191 rdf:type schema:Person
    192 sg:person.01154135402.43 schema:affiliation https://www.grid.ac/institutes/grid.4711.3
    193 schema:familyName Gutiérrez-González
    194 schema:givenName A.
    195 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01154135402.43
    196 rdf:type schema:Person
    197 sg:person.01166154641.35 schema:affiliation https://www.grid.ac/institutes/grid.73221.35
    198 schema:familyName Dominguez
    199 schema:givenName G.
    200 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01166154641.35
    201 rdf:type schema:Person
    202 sg:person.01265024146.68 schema:affiliation https://www.grid.ac/institutes/grid.81821.32
    203 schema:familyName Perona
    204 schema:givenName R.
    205 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01265024146.68
    206 rdf:type schema:Person
    207 sg:person.01270217230.39 schema:affiliation https://www.grid.ac/institutes/grid.81821.32
    208 schema:familyName Belda-Iniesta
    209 schema:givenName C.
    210 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01270217230.39
    211 rdf:type schema:Person
    212 sg:person.01270364002.34 schema:affiliation https://www.grid.ac/institutes/grid.4711.3
    213 schema:familyName Bargiela-Iparraguirre
    214 schema:givenName J.
    215 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01270364002.34
    216 rdf:type schema:Person
    217 sg:person.013205147567.38 schema:affiliation https://www.grid.ac/institutes/grid.410526.4
    218 schema:familyName García Alfonso
    219 schema:givenName P.
    220 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013205147567.38
    221 rdf:type schema:Person
    222 sg:pub.10.1007/bf02899281 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005367300
    223 https://doi.org/10.1007/bf02899281
    224 rdf:type schema:CreativeWork
    225 sg:pub.10.1007/s00280-007-0508-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036594365
    226 https://doi.org/10.1007/s00280-007-0508-6
    227 rdf:type schema:CreativeWork
    228 sg:pub.10.1007/s10120-011-0043-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030938566
    229 https://doi.org/10.1007/s10120-011-0043-3
    230 rdf:type schema:CreativeWork
    231 sg:pub.10.1007/s10120-011-0118-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018206312
    232 https://doi.org/10.1007/s10120-011-0118-1
    233 rdf:type schema:CreativeWork
    234 sg:pub.10.1007/s10637-010-9474-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029378423
    235 https://doi.org/10.1007/s10637-010-9474-7
    236 rdf:type schema:CreativeWork
    237 sg:pub.10.1038/bjc.2011.390 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048865019
    238 https://doi.org/10.1038/bjc.2011.390
    239 rdf:type schema:CreativeWork
    240 sg:pub.10.1038/nature03097 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012054610
    241 https://doi.org/10.1038/nature03097
    242 rdf:type schema:CreativeWork
    243 sg:pub.10.1038/nature08467 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052581766
    244 https://doi.org/10.1038/nature08467
    245 rdf:type schema:CreativeWork
    246 sg:pub.10.1038/nature10802 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008061452
    247 https://doi.org/10.1038/nature10802
    248 rdf:type schema:CreativeWork
    249 sg:pub.10.1038/ncb0510-424 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051620797
    250 https://doi.org/10.1038/ncb0510-424
    251 rdf:type schema:CreativeWork
    252 sg:pub.10.1038/ncb2051 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050909369
    253 https://doi.org/10.1038/ncb2051
    254 rdf:type schema:CreativeWork
    255 sg:pub.10.1038/nrc2251 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044052352
    256 https://doi.org/10.1038/nrc2251
    257 rdf:type schema:CreativeWork
    258 sg:pub.10.1038/nrc2297 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041493658
    259 https://doi.org/10.1038/nrc2297
    260 rdf:type schema:CreativeWork
    261 sg:pub.10.1038/nrm3115 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018735275
    262 https://doi.org/10.1038/nrm3115
    263 rdf:type schema:CreativeWork
    264 sg:pub.10.1038/nsmb.2245 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025645333
    265 https://doi.org/10.1038/nsmb.2245
    266 rdf:type schema:CreativeWork
    267 https://app.dimensions.ai/details/publication/pub.1077653754 schema:CreativeWork
    268 https://app.dimensions.ai/details/publication/pub.1077926254 schema:CreativeWork
    269 https://doi.org/10.1001/jama.2010.534 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008087002
    270 rdf:type schema:CreativeWork
    271 https://doi.org/10.1002/14651858.cd004064.pub3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012727308
    272 rdf:type schema:CreativeWork
    273 https://doi.org/10.1002/ijc.10272 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040678393
    274 rdf:type schema:CreativeWork
    275 https://doi.org/10.1002/ijc.26292 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006293373
    276 rdf:type schema:CreativeWork
    277 https://doi.org/10.1016/0014-4827(88)90265-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041300635
    278 rdf:type schema:CreativeWork
    279 https://doi.org/10.1016/j.bbcan.2008.05.002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039720493
    280 rdf:type schema:CreativeWork
    281 https://doi.org/10.1016/j.biocel.2009.11.011 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023229065
    282 rdf:type schema:CreativeWork
    283 https://doi.org/10.1016/j.canlet.2008.08.026 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010553876
    284 rdf:type schema:CreativeWork
    285 https://doi.org/10.1016/j.ccr.2009.08.020 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024694567
    286 rdf:type schema:CreativeWork
    287 https://doi.org/10.1016/j.ctrv.2010.01.005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023167426
    288 rdf:type schema:CreativeWork
    289 https://doi.org/10.1016/j.devcel.2004.09.002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037134328
    290 rdf:type schema:CreativeWork
    291 https://doi.org/10.1016/j.dnarep.2004.03.033 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036174050
    292 rdf:type schema:CreativeWork
    293 https://doi.org/10.1016/j.dnarep.2009.04.012 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025189830
    294 rdf:type schema:CreativeWork
    295 https://doi.org/10.1016/j.febslet.2010.07.057 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009333473
    296 rdf:type schema:CreativeWork
    297 https://doi.org/10.1016/j.molcel.2012.02.015 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040202134
    298 rdf:type schema:CreativeWork
    299 https://doi.org/10.1016/j.mrgentox.2004.01.013 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018422732
    300 rdf:type schema:CreativeWork
    301 https://doi.org/10.1016/s0014-5793(01)02756-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036265029
    302 rdf:type schema:CreativeWork
    303 https://doi.org/10.1016/s1097-2765(00)80202-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047827768
    304 rdf:type schema:CreativeWork
    305 https://doi.org/10.1038/emboj.2010.112 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026038005
    306 rdf:type schema:CreativeWork
    307 https://doi.org/10.1038/embor.2011.62 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007430735
    308 rdf:type schema:CreativeWork
    309 https://doi.org/10.1074/jbc.c300554200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045662235
    310 rdf:type schema:CreativeWork
    311 https://doi.org/10.1074/jbc.m208685200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014698192
    312 rdf:type schema:CreativeWork
    313 https://doi.org/10.1083/jcb.200812045 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047183790
    314 rdf:type schema:CreativeWork
    315 https://doi.org/10.1111/j.1476-5381.2009.00607.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1038659257
    316 rdf:type schema:CreativeWork
    317 https://doi.org/10.1126/science.1071398 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062446509
    318 rdf:type schema:CreativeWork
    319 https://doi.org/10.1128/mcb.24.2.708-718.2004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050125987
    320 rdf:type schema:CreativeWork
    321 https://doi.org/10.1158/0008-5472.can-06-3095 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022304739
    322 rdf:type schema:CreativeWork
    323 https://doi.org/10.1158/0008-5472.can-12-2354 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024662504
    324 rdf:type schema:CreativeWork
    325 https://doi.org/10.1158/1078-0432.ccr-10-1215 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000573421
    326 rdf:type schema:CreativeWork
    327 https://doi.org/10.1158/1078-0432.ccr-10-2927 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044700020
    328 rdf:type schema:CreativeWork
    329 https://doi.org/10.1158/1535-7163.mct-06-0567 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022539252
    330 rdf:type schema:CreativeWork
    331 https://doi.org/10.1200/jco.2006.06.8429 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023864538
    332 rdf:type schema:CreativeWork
    333 https://doi.org/10.1371/journal.pgen.1001385 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040662320
    334 rdf:type schema:CreativeWork
    335 https://doi.org/10.1371/journal.pone.0015724 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016691440
    336 rdf:type schema:CreativeWork
    337 https://doi.org/10.2174/138161210789941801 schema:sameAs https://app.dimensions.ai/details/publication/pub.1069167154
    338 rdf:type schema:CreativeWork
    339 https://doi.org/10.4149/gpb_2012_002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1072261625
    340 rdf:type schema:CreativeWork
    341 https://www.grid.ac/institutes/grid.410526.4 schema:alternateName Hospital General Universitario Gregorio Marañón
    342 schema:name Department of Medical Oncology, Gregorio Marañon Hospital, Madrid, Spain
    343 rdf:type schema:Organization
    344 https://www.grid.ac/institutes/grid.4711.3 schema:alternateName Spanish National Research Council
    345 schema:name Biomedical Research Institute of Madrid, Madrid CSIC/UAM, C/Arturo Duperier 4, 28029, Madrid, Spain
    346 Department of Biochemistry, School of Medicine, UAM, Madrid, Spain
    347 rdf:type schema:Organization
    348 https://www.grid.ac/institutes/grid.73221.35 schema:alternateName Hospital Universitario Puerta de Hierro Majadahonda
    349 schema:name Department of Medical Oncology, University Hospital Puerta de Hierro, UAM, Madrid, Spain
    350 rdf:type schema:Organization
    351 https://www.grid.ac/institutes/grid.81821.32 schema:alternateName Hospital Universitario La Paz
    352 schema:name Biomarkers and Experimental Therapeutics Group, IdiPAZ, University Hospital La Paz, Madrid, Spain
    353 Biomedical Research Institute of Madrid, Madrid CSIC/UAM, C/Arturo Duperier 4, 28029, Madrid, Spain
    354 CIBER on Rare Diseases (CIBERER), Valencia, Spain
    355 Thoracic, Head & Neck and Brain Oncology Unit, CIOCC Centro integral Oncológico Clara Campal. GHM Grupo Hospital de Madrid, Madrid, Spain
    356 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...