Ontology type: schema:ScholarlyArticle
2006-03-13
AUTHORSP. Crisanti, O. Laplace, E. Lecain, L. Jonet, J. C. Jeanny, B. Omri
ABSTRACTIntravitreal NMDA injection has been shown to induce the excitotoxic loss of retinal cells. The retinal ganglion cell apoptosis induced by NMDA is thought to play an important role in retinal ischemia injury and NMDA-injected rat has been used as a model of neuronal loss in diseases such as glaucoma. In this experimental model, we studied the early effects of NMDA leading to the degeneration of retinal ganglion cells. PKCζ regulates the NF-κB pathway in cellular responses to various stresses and we have shown that aspirin inhibits purified human PKCζ. We therefore investigated the molecular mechanism by which retinal cells limit ocular injury following NMDA treatment. We found that the NMDA-induced apoptosis of ganglion cells was mediated, at least partly, by PKCζ. This enzyme was activated early in the cellular response to NMDA. Prolonged activation was followed by PKCζ cleavage, and nuclear translocation of the C-terminal region of this protein—a critical event for the survival of retinal cells. We also found that pretreatment with aspirin or the coinjection of NMDA with a specific PKCζ inhibitor counteracted the effects of NMDA. These findings provide new insight into the role played by PKCζ in neuronal loss in glaucoma. More... »
PAGES983-991
http://scigraph.springernature.com/pub.10.1007/s10495-006-6750-2
DOIhttp://dx.doi.org/10.1007/s10495-006-6750-2
DIMENSIONShttps://app.dimensions.ai/details/publication/pub.1002731405
PUBMEDhttps://www.ncbi.nlm.nih.gov/pubmed/16547586
JSON-LD is the canonical representation for SciGraph data.
TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT
[
{
"@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json",
"about": [
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Biological Sciences",
"type": "DefinedTerm"
},
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Medical and Health Sciences",
"type": "DefinedTerm"
},
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0601",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Biochemistry and Cell Biology",
"type": "DefinedTerm"
},
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1113",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Ophthalmology and Optometry",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Animals",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Apoptosis",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Aspirin",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Male",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "N-Methylaspartate",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Protein Kinase C",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Rats",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Rats, Wistar",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Retinal Ganglion Cells",
"type": "DefinedTerm"
}
],
"author": [
{
"affiliation": {
"alternateName": "Unit\u00e9 598 de l\u2019INSERM Physiopathologie des maladies oculaires, Innovations th\u00e9rapeutiques, France",
"id": "http://www.grid.ac/institutes/None",
"name": [
"Unit\u00e9 598 de l\u2019INSERM Physiopathologie des maladies oculaires, Innovations th\u00e9rapeutiques, France"
],
"type": "Organization"
},
"familyName": "Crisanti",
"givenName": "P.",
"id": "sg:person.01030121556.37",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01030121556.37"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Unit\u00e9 598 de l\u2019INSERM Physiopathologie des maladies oculaires, Innovations th\u00e9rapeutiques, France",
"id": "http://www.grid.ac/institutes/None",
"name": [
"Unit\u00e9 598 de l\u2019INSERM Physiopathologie des maladies oculaires, Innovations th\u00e9rapeutiques, France"
],
"type": "Organization"
},
"familyName": "Laplace",
"givenName": "O.",
"id": "sg:person.01026072502.26",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01026072502.26"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "UMR 7060, France",
"id": "http://www.grid.ac/institutes/None",
"name": [
"UMR 7060, France"
],
"type": "Organization"
},
"familyName": "Lecain",
"givenName": "E.",
"id": "sg:person.01001407573.23",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01001407573.23"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Unit\u00e9 598 de l\u2019INSERM Physiopathologie des maladies oculaires, Innovations th\u00e9rapeutiques, France",
"id": "http://www.grid.ac/institutes/None",
"name": [
"Unit\u00e9 598 de l\u2019INSERM Physiopathologie des maladies oculaires, Innovations th\u00e9rapeutiques, France"
],
"type": "Organization"
},
"familyName": "Jonet",
"givenName": "L.",
"id": "sg:person.01052425027.09",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01052425027.09"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Unit\u00e9 598 de l\u2019INSERM Physiopathologie des maladies oculaires, Innovations th\u00e9rapeutiques, France",
"id": "http://www.grid.ac/institutes/None",
"name": [
"Unit\u00e9 598 de l\u2019INSERM Physiopathologie des maladies oculaires, Innovations th\u00e9rapeutiques, France"
],
"type": "Organization"
},
"familyName": "Jeanny",
"givenName": "J. C.",
"id": "sg:person.01340415621.24",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01340415621.24"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Institut Biom\u00e9dical des Cordeliers, 15 Rue de l\u2019\u00e9cole de M\u00e9decine, 75270, Paris Cedex 06, France",
"id": "http://www.grid.ac/institutes/grid.417925.c",
"name": [
"Unit\u00e9 598 de l\u2019INSERM Physiopathologie des maladies oculaires, Innovations th\u00e9rapeutiques, France",
"Universit\u00e9 Pierre et Marie Curie, Paris VI, France",
"Institut Biom\u00e9dical des Cordeliers, 15 Rue de l\u2019\u00e9cole de M\u00e9decine, 75270, Paris Cedex 06, France"
],
"type": "Organization"
},
"familyName": "Omri",
"givenName": "B.",
"id": "sg:person.01277466405.65",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01277466405.65"
],
"type": "Person"
}
],
"datePublished": "2006-03-13",
"datePublishedReg": "2006-03-13",
"description": "Intravitreal NMDA injection has been shown to induce the excitotoxic loss of retinal cells. The retinal ganglion cell apoptosis induced by NMDA is thought to play an important role in retinal ischemia injury and NMDA-injected rat has been used as a model of neuronal loss in diseases such as glaucoma. In this experimental model, we studied the early effects of NMDA leading to the degeneration of retinal ganglion cells. PKC\u03b6 regulates the NF-\u03baB pathway in cellular responses to various stresses and we have shown that aspirin inhibits purified human PKC\u03b6. We therefore investigated the molecular mechanism by which retinal cells limit ocular injury following NMDA treatment. We found that the NMDA-induced apoptosis of ganglion cells was mediated, at least partly, by PKC\u03b6. This enzyme was activated early in the cellular response to NMDA. Prolonged activation was followed by PKC\u03b6 cleavage, and nuclear translocation of the C-terminal region of this protein\u2014a critical event for the survival of retinal cells. We also found that pretreatment with aspirin or the coinjection of NMDA with a specific PKC\u03b6 inhibitor counteracted the effects of NMDA. These findings provide new insight into the role played by PKC\u03b6 in neuronal loss in glaucoma.",
"genre": "article",
"id": "sg:pub.10.1007/s10495-006-6750-2",
"inLanguage": "en",
"isAccessibleForFree": false,
"isPartOf": [
{
"id": "sg:journal.1117236",
"issn": [
"1360-8185",
"1573-675X"
],
"name": "Apoptosis",
"publisher": "Springer Nature",
"type": "Periodical"
},
{
"issueNumber": "6",
"type": "PublicationIssue"
},
{
"type": "PublicationVolume",
"volumeNumber": "11"
}
],
"keywords": [
"retinal cells",
"neuronal loss",
"ganglion cells",
"retinal ganglion cell death",
"retinal ganglion cell apoptosis",
"retinal ischemia injury",
"ganglion cell death",
"effects of NMDA",
"retinal ganglion cells",
"ganglion cell apoptosis",
"NF-\u03baB pathway",
"intravitreal NMDA injection",
"excitotoxic loss",
"ocular injuries",
"NMDA injection",
"ischemia injury",
"Aspirin inhibits",
"NMDA treatment",
"NMDA",
"PKC\u03b6 inhibitor",
"cellular responses",
"experimental model",
"role of PKC\u03b6",
"cell apoptosis",
"early effects",
"nuclear translocation",
"prolonged activation",
"aspirin",
"glaucoma",
"injury",
"cell death",
"molecular mechanisms",
"cells",
"apoptosis",
"PKC\u03b6",
"critical events",
"rats",
"disease",
"degeneration",
"important role",
"response",
"prevention",
"role",
"death",
"survival",
"injection",
"treatment",
"loss",
"inhibits",
"coinjection",
"inhibitors",
"activation",
"pretreatment",
"effect",
"findings",
"pathway",
"new insights",
"translocation",
"protein",
"terminal region",
"events",
"enzyme",
"mechanism",
"stress",
"model",
"cleavage",
"region",
"insights"
],
"name": "The role of PKC\u03b6 in NMDA-induced retinal ganglion cell death: Prevention by aspirin",
"pagination": "983-991",
"productId": [
{
"name": "dimensions_id",
"type": "PropertyValue",
"value": [
"pub.1002731405"
]
},
{
"name": "doi",
"type": "PropertyValue",
"value": [
"10.1007/s10495-006-6750-2"
]
},
{
"name": "pubmed_id",
"type": "PropertyValue",
"value": [
"16547586"
]
}
],
"sameAs": [
"https://doi.org/10.1007/s10495-006-6750-2",
"https://app.dimensions.ai/details/publication/pub.1002731405"
],
"sdDataset": "articles",
"sdDatePublished": "2022-05-20T07:23",
"sdLicense": "https://scigraph.springernature.com/explorer/license/",
"sdPublisher": {
"name": "Springer Nature - SN SciGraph project",
"type": "Organization"
},
"sdSource": "s3://com-springernature-scigraph/baseset/20220519/entities/gbq_results/article/article_422.jsonl",
"type": "ScholarlyArticle",
"url": "https://doi.org/10.1007/s10495-006-6750-2"
}
]Download the RDF metadata as: json-ld nt turtle xml License info
JSON-LD is a popular format for linked data which is fully compatible with JSON.
curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s10495-006-6750-2'
N-Triples is a line-based linked data format ideal for batch operations.
curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s10495-006-6750-2'
Turtle is a human-readable linked data format.
curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s10495-006-6750-2'
RDF/XML is a standard XML format for linked data.
curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s10495-006-6750-2'
This table displays all metadata directly associated to this object as RDF triples.
216 TRIPLES
21 PREDICATES
105 URIs
95 LITERALS
16 BLANK NODES