Cleavage of MAGI-1, a tight junction PDZ protein, by caspases is an important step for cell-cell detachment in apoptosis View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2007-02

AUTHORS

Uroš Gregorc, Saška Ivanova, Miranda Thomas, Ernesto Guccione, Britt Glaunsinger, Ron Javier, Vito Turk, Lawrence Banks, Boris Turk

ABSTRACT

MAGI-1, a member of the MAGUK family of proteins, is shown to be rapidly cleaved during Fas-induced apoptosis in mouse 3T3 A31 cells, and in UV irradiation- and staurosporine-induced apoptosis in HaCaT cells. This generates a 97 kDa N-terminal fragment that dissociates from the cell membrane; a process that is largely prevented in the presence of the caspase inhibitor Z-VAD-fmk. In addition, we show that in vitro translated radiolabelled MAGI-1 is efficiently cleaved into 97 kDa and 68 kDa fragments by caspases-3 and -7 at physiological concentrations and mutating the MAGI-1 Asp(761) to Ala completely abolished the caspase-induced cleavage. Moreover, in HaCaT cells overexpressing the MAGI-1 Asp(761)Ala mutant the disruption of cell-cell contacts was delayed during apoptosis, whereas other caspase-dependent processes such as nuclear condensation were not affected, suggesting that cell detachment is parallel to them. Thus, MAGI-1 cleavage appears to be an important step in the disassembly of cell-cell contacts during apoptosis. More... »

PAGES

343-354

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s10495-006-0579-6

DOI

http://dx.doi.org/10.1007/s10495-006-0579-6

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1042054263

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/17191119


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