Bim plays a crucial role in synergistic induction of apoptosis by the histone deacetylase inhibitor SBHA and TRAIL in melanoma ... View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2006-10-17

AUTHORS

Susan Gillespie, Jodie Borrow, Xu Dong Zhang, Peter Hersey

ABSTRACT

The wide variation in sensitivity of cancer cells to TRAIL- or histone deacetylase (HDAC) inhibitor — induced apoptosis precludes successful treatment of cancer with these agents. We report here that TRAIL and SBHA synergistically induce apoptosis of melanoma cells as revealed by quantitative analysis using the normalized isobologram method. This is supported by enhanced activation of caspase-3 and cleavage of its substrates, PARP and ICAD. Co-treatment with SBHA and TRAIL did not enhance formation of the death-inducing signaling complex (DISC) and processing of caspase-8 and Bid, but potentiated activation of Bax and release of Cytochrome C and Smac/DIABLO from mitochondria into the cytosol. SBHA down-regulated Bcl-XL, Mcl-1 and XIAP, but up-regulated Bax, Bak, and the BH3-only protein BimEL. Up-regulation of the latter by SBHA was attenuated by the presence of TRAIL, which was inhibitable by the pan-caspase inhibitor z-VAD-fmk. Inhibition of Bim by siRNA attenuated conformational changes of Bax, mitochondrial apoptotic events, and activation of caspase-3, leading to marked inhibition of the synergy between SBHA and TRAIL. Thus, Bim plays an essential role in synergistic induction of apoptosis by SBHA and TRAIL in melanoma. More... »

PAGES

2251-2265

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s10495-006-0283-6

DOI

http://dx.doi.org/10.1007/s10495-006-0283-6

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1032980663

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/17051334


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biological Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0601", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biochemistry and Cell Biology", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Oncology and Carcinogenesis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Apoptosis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Apoptosis Regulatory Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "BH3 Interacting Domain Death Agonist Protein", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Bcl-2-Like Protein 11", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Caspase 8", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Down-Regulation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Enzyme Inhibitors", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Histone Deacetylase Inhibitors", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Histone Deacetylases", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Hydroxamic Acids", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Melanoma", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Membrane Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mitochondria", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Myeloid Cell Leukemia Sequence 1 Protein", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Neoplasm Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Proto-Oncogene Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Proto-Oncogene Proteins c-bcl-2", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "RNA, Small Interfering", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "TNF-Related Apoptosis-Inducing Ligand", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Up-Regulation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "X-Linked Inhibitor of Apoptosis Protein", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "bcl-2 Homologous Antagonist-Killer Protein", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "bcl-2-Associated X Protein", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "bcl-X Protein", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Immunology and Oncology Unit, Room 443, Newcastle Misericordiae Hospital, NSW, Australia", 
          "id": "http://www.grid.ac/institutes/None", 
          "name": [
            "Immunology and Oncology Unit, Room 443, Newcastle Misericordiae Hospital, NSW, Australia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Gillespie", 
        "givenName": "Susan", 
        "id": "sg:person.01311773466.89", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01311773466.89"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Immunology and Oncology Unit, Room 443, Newcastle Misericordiae Hospital, NSW, Australia", 
          "id": "http://www.grid.ac/institutes/None", 
          "name": [
            "Immunology and Oncology Unit, Room 443, Newcastle Misericordiae Hospital, NSW, Australia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Borrow", 
        "givenName": "Jodie", 
        "id": "sg:person.01140572250.01", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01140572250.01"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Room 443, David Maddison Clinical Sciences Building, Cnr. King & Watt Streets, 2300, Newcastle, NSW, Australia", 
          "id": "http://www.grid.ac/institutes/None", 
          "name": [
            "Immunology and Oncology Unit, Room 443, Newcastle Misericordiae Hospital, NSW, Australia", 
            "Room 443, David Maddison Clinical Sciences Building, Cnr. King & Watt Streets, 2300, Newcastle, NSW, Australia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Zhang", 
        "givenName": "Xu Dong", 
        "id": "sg:person.01210116316.18", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01210116316.18"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Room 443, David Maddison Clinical Sciences Building, Cnr. King & Watt Streets, 2300, Newcastle, NSW, Australia", 
          "id": "http://www.grid.ac/institutes/None", 
          "name": [
            "Immunology and Oncology Unit, Room 443, Newcastle Misericordiae Hospital, NSW, Australia", 
            "Room 443, David Maddison Clinical Sciences Building, Cnr. King & Watt Streets, 2300, Newcastle, NSW, Australia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hersey", 
        "givenName": "Peter", 
        "id": "sg:person.01073667716.42", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01073667716.42"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1038/20959", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031691936", 
          "https://doi.org/10.1038/20959"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.onc.1208191", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030634267", 
          "https://doi.org/10.1038/sj.onc.1208191"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.onc.1207970", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048306287", 
          "https://doi.org/10.1038/sj.onc.1207970"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.onc.1207830", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049638392", 
          "https://doi.org/10.1038/sj.onc.1207830"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.cdd.4401507", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020681987", 
          "https://doi.org/10.1038/sj.cdd.4401507"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/5517", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010598958", 
          "https://doi.org/10.1038/5517"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.cdd.4401535", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015856802", 
          "https://doi.org/10.1038/sj.cdd.4401535"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ncb1026", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012014764", 
          "https://doi.org/10.1038/ncb1026"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/38664", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026663914", 
          "https://doi.org/10.1038/38664"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/35101078", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021222128", 
          "https://doi.org/10.1038/35101078"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2006-10-17", 
    "datePublishedReg": "2006-10-17", 
    "description": "The wide variation in sensitivity of cancer cells to TRAIL- or histone deacetylase (HDAC) inhibitor \u2014 induced apoptosis precludes successful treatment of cancer with these agents. We report here that TRAIL and SBHA synergistically induce apoptosis of melanoma cells as revealed by quantitative analysis using the normalized isobologram method. This is supported by enhanced activation of caspase-3 and cleavage of its substrates, PARP and ICAD. Co-treatment with SBHA and TRAIL did not enhance formation of the death-inducing signaling complex (DISC) and processing of caspase-8 and Bid, but potentiated activation of Bax and release of Cytochrome C and Smac/DIABLO from mitochondria into the cytosol. SBHA down-regulated Bcl-XL, Mcl-1 and XIAP, but up-regulated Bax, Bak, and the BH3-only protein BimEL. Up-regulation of the latter by SBHA was attenuated by the presence of TRAIL, which was inhibitable by the pan-caspase inhibitor z-VAD-fmk. Inhibition of Bim by siRNA attenuated conformational changes of Bax, mitochondrial apoptotic events, and activation of caspase-3, leading to marked inhibition of the synergy between SBHA and TRAIL. Thus, Bim plays an essential role in synergistic induction of apoptosis by SBHA and TRAIL in melanoma.", 
    "genre": "article", 
    "id": "sg:pub.10.1007/s10495-006-0283-6", 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1117236", 
        "issn": [
          "1360-8185", 
          "1573-675X"
        ], 
        "name": "Apoptosis", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "12", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "11"
      }
    ], 
    "keywords": [
      "histone deacetylase inhibitor-induced apoptosis", 
      "pan-caspase inhibitor z-VAD", 
      "mitochondrial apoptotic events", 
      "inhibition of Bim", 
      "Smac/DIABLO", 
      "synergistic induction", 
      "activation of Bax", 
      "inhibitor-induced apoptosis", 
      "caspase-3", 
      "protein BimEL", 
      "melanoma cells", 
      "Z-VAD", 
      "apoptotic events", 
      "caspase-8", 
      "Bcl-xL", 
      "Mcl-1", 
      "conformational changes", 
      "cytochrome c", 
      "essential role", 
      "presence of TRAIL", 
      "apoptosis", 
      "cancer cells", 
      "SBHA", 
      "Bax", 
      "enhanced activation", 
      "cells", 
      "activation", 
      "crucial role", 
      "BimEL", 
      "induction", 
      "fmk", 
      "XIAP", 
      "Bak", 
      "BH3", 
      "DIABLO", 
      "mitochondria", 
      "cytosol", 
      "BIM", 
      "inhibition", 
      "PARP", 
      "marked inhibition", 
      "siRNA", 
      "ICAD", 
      "role", 
      "trails", 
      "cleavage", 
      "complexes", 
      "substrate", 
      "wide variation", 
      "variation", 
      "formation", 
      "release", 
      "quantitative analysis", 
      "cancer", 
      "events", 
      "presence", 
      "changes", 
      "melanoma", 
      "isobologram method", 
      "analysis", 
      "synergy", 
      "agents", 
      "bid", 
      "sensitivity", 
      "treatment", 
      "processing", 
      "method", 
      "successful treatment"
    ], 
    "name": "Bim plays a crucial role in synergistic induction of apoptosis by the histone deacetylase inhibitor SBHA and TRAIL in melanoma cells", 
    "pagination": "2251-2265", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1032980663"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s10495-006-0283-6"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "17051334"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s10495-006-0283-6", 
      "https://app.dimensions.ai/details/publication/pub.1032980663"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2022-11-24T20:52", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20221124/entities/gbq_results/article/article_414.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1007/s10495-006-0283-6"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s10495-006-0283-6'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s10495-006-0283-6'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s10495-006-0283-6'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s10495-006-0283-6'


 

This table displays all metadata directly associated to this object as RDF triples.

300 TRIPLES      21 PREDICATES      130 URIs      110 LITERALS      32 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s10495-006-0283-6 schema:about N026b0915dd3e48e0ae6f349a9383e5b8
2 N09b42a95513d4da787becdfacb2223c1
3 N0ee481a4a1da4cb2bdfaf06b95b735c1
4 N2f23e92c3c1c4893a076f0f53a13d8d4
5 N3b790a7ffdc746f0bb10a5365d9e4014
6 N4050bbedf002469bbe24507205f7a5fe
7 N563d55eacbba4ad3bc9ce965db70e8b2
8 N67b989bb6891456da00e4247d6aa502b
9 N681b4a6315cb4a6e8298caf61c70c817
10 N6ac8d76d9d41450ebf4fb671456756be
11 N6b2df41d1c65452d94647ce9b9a4e3f7
12 N77f63e690f5e4640b5a888b38dd3a945
13 N7cfd10cff1e249a49abd672855981572
14 N7eef5591a9bd4687ba9e73c9af0ae3fb
15 N9ec56335872049e4ad2f94d1f4883890
16 Na3a91ad825254966bd958e2e21ac40a7
17 Na79c40450a4a4aeaa6a453543496b6cb
18 Nb28f67b73dd24351af877fe894160b8f
19 Nb4a2a60f243d4da18db71ddaae8ce1fd
20 Nb57a4c5092c9448d997955e6e206b420
21 Nc07dab4d19444a448e3f2960a56a7338
22 Nc21d5dfb40734f4d877d399670f8e235
23 Nddbf1c1eeaad411b9540ba83f9d7a274
24 Ne746461832d544e7bd3e9586aa16d6f0
25 Nf9b98daa1ab8464f945808623fe10d35
26 anzsrc-for:06
27 anzsrc-for:0601
28 anzsrc-for:11
29 anzsrc-for:1112
30 schema:author N8664ec0525b4490f84cfbc258e116cc9
31 schema:citation sg:pub.10.1038/20959
32 sg:pub.10.1038/35101078
33 sg:pub.10.1038/38664
34 sg:pub.10.1038/5517
35 sg:pub.10.1038/ncb1026
36 sg:pub.10.1038/sj.cdd.4401507
37 sg:pub.10.1038/sj.cdd.4401535
38 sg:pub.10.1038/sj.onc.1207830
39 sg:pub.10.1038/sj.onc.1207970
40 sg:pub.10.1038/sj.onc.1208191
41 schema:datePublished 2006-10-17
42 schema:datePublishedReg 2006-10-17
43 schema:description The wide variation in sensitivity of cancer cells to TRAIL- or histone deacetylase (HDAC) inhibitor — induced apoptosis precludes successful treatment of cancer with these agents. We report here that TRAIL and SBHA synergistically induce apoptosis of melanoma cells as revealed by quantitative analysis using the normalized isobologram method. This is supported by enhanced activation of caspase-3 and cleavage of its substrates, PARP and ICAD. Co-treatment with SBHA and TRAIL did not enhance formation of the death-inducing signaling complex (DISC) and processing of caspase-8 and Bid, but potentiated activation of Bax and release of Cytochrome C and Smac/DIABLO from mitochondria into the cytosol. SBHA down-regulated Bcl-XL, Mcl-1 and XIAP, but up-regulated Bax, Bak, and the BH3-only protein BimEL. Up-regulation of the latter by SBHA was attenuated by the presence of TRAIL, which was inhibitable by the pan-caspase inhibitor z-VAD-fmk. Inhibition of Bim by siRNA attenuated conformational changes of Bax, mitochondrial apoptotic events, and activation of caspase-3, leading to marked inhibition of the synergy between SBHA and TRAIL. Thus, Bim plays an essential role in synergistic induction of apoptosis by SBHA and TRAIL in melanoma.
44 schema:genre article
45 schema:isAccessibleForFree false
46 schema:isPartOf Nb62cdc9f409a410f956542dd5392ce43
47 Nc407837d70d745eb87910dbaf32b337d
48 sg:journal.1117236
49 schema:keywords BH3
50 BIM
51 Bak
52 Bax
53 Bcl-xL
54 BimEL
55 DIABLO
56 ICAD
57 Mcl-1
58 PARP
59 SBHA
60 Smac/DIABLO
61 XIAP
62 Z-VAD
63 activation
64 activation of Bax
65 agents
66 analysis
67 apoptosis
68 apoptotic events
69 bid
70 cancer
71 cancer cells
72 caspase-3
73 caspase-8
74 cells
75 changes
76 cleavage
77 complexes
78 conformational changes
79 crucial role
80 cytochrome c
81 cytosol
82 enhanced activation
83 essential role
84 events
85 fmk
86 formation
87 histone deacetylase inhibitor-induced apoptosis
88 induction
89 inhibition
90 inhibition of Bim
91 inhibitor-induced apoptosis
92 isobologram method
93 marked inhibition
94 melanoma
95 melanoma cells
96 method
97 mitochondria
98 mitochondrial apoptotic events
99 pan-caspase inhibitor z-VAD
100 presence
101 presence of TRAIL
102 processing
103 protein BimEL
104 quantitative analysis
105 release
106 role
107 sensitivity
108 siRNA
109 substrate
110 successful treatment
111 synergistic induction
112 synergy
113 trails
114 treatment
115 variation
116 wide variation
117 schema:name Bim plays a crucial role in synergistic induction of apoptosis by the histone deacetylase inhibitor SBHA and TRAIL in melanoma cells
118 schema:pagination 2251-2265
119 schema:productId N2099fd91f0a94ca38432d1c2a1b0d170
120 N6f7ee9d1f0c6431390ed5d26ac26c551
121 Nc0047e821b28485d9ccd046df049b771
122 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032980663
123 https://doi.org/10.1007/s10495-006-0283-6
124 schema:sdDatePublished 2022-11-24T20:52
125 schema:sdLicense https://scigraph.springernature.com/explorer/license/
126 schema:sdPublisher N5e19847d05c741279b6991537d40f12f
127 schema:url https://doi.org/10.1007/s10495-006-0283-6
128 sgo:license sg:explorer/license/
129 sgo:sdDataset articles
130 rdf:type schema:ScholarlyArticle
131 N026b0915dd3e48e0ae6f349a9383e5b8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
132 schema:name Caspase 8
133 rdf:type schema:DefinedTerm
134 N09ae709d8f484a4b8dc53bae79d4bc3f rdf:first sg:person.01073667716.42
135 rdf:rest rdf:nil
136 N09b42a95513d4da787becdfacb2223c1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
137 schema:name Humans
138 rdf:type schema:DefinedTerm
139 N0ee481a4a1da4cb2bdfaf06b95b735c1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
140 schema:name BH3 Interacting Domain Death Agonist Protein
141 rdf:type schema:DefinedTerm
142 N2099fd91f0a94ca38432d1c2a1b0d170 schema:name dimensions_id
143 schema:value pub.1032980663
144 rdf:type schema:PropertyValue
145 N2f23e92c3c1c4893a076f0f53a13d8d4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
146 schema:name Down-Regulation
147 rdf:type schema:DefinedTerm
148 N3b790a7ffdc746f0bb10a5365d9e4014 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
149 schema:name RNA, Small Interfering
150 rdf:type schema:DefinedTerm
151 N4050bbedf002469bbe24507205f7a5fe schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
152 schema:name X-Linked Inhibitor of Apoptosis Protein
153 rdf:type schema:DefinedTerm
154 N563d55eacbba4ad3bc9ce965db70e8b2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
155 schema:name Proto-Oncogene Proteins c-bcl-2
156 rdf:type schema:DefinedTerm
157 N5e19847d05c741279b6991537d40f12f schema:name Springer Nature - SN SciGraph project
158 rdf:type schema:Organization
159 N67b989bb6891456da00e4247d6aa502b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
160 schema:name Bcl-2-Like Protein 11
161 rdf:type schema:DefinedTerm
162 N681b4a6315cb4a6e8298caf61c70c817 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
163 schema:name Up-Regulation
164 rdf:type schema:DefinedTerm
165 N6ac8d76d9d41450ebf4fb671456756be schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
166 schema:name bcl-X Protein
167 rdf:type schema:DefinedTerm
168 N6b2df41d1c65452d94647ce9b9a4e3f7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
169 schema:name bcl-2 Homologous Antagonist-Killer Protein
170 rdf:type schema:DefinedTerm
171 N6f7ee9d1f0c6431390ed5d26ac26c551 schema:name pubmed_id
172 schema:value 17051334
173 rdf:type schema:PropertyValue
174 N77f63e690f5e4640b5a888b38dd3a945 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
175 schema:name Neoplasm Proteins
176 rdf:type schema:DefinedTerm
177 N7cfd10cff1e249a49abd672855981572 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
178 schema:name Hydroxamic Acids
179 rdf:type schema:DefinedTerm
180 N7eef5591a9bd4687ba9e73c9af0ae3fb schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
181 schema:name Histone Deacetylase Inhibitors
182 rdf:type schema:DefinedTerm
183 N7f662d0c54524d5bb6ecf2510d9a2f1d rdf:first sg:person.01210116316.18
184 rdf:rest N09ae709d8f484a4b8dc53bae79d4bc3f
185 N8664ec0525b4490f84cfbc258e116cc9 rdf:first sg:person.01311773466.89
186 rdf:rest N8788bc86fd254b6da09a44fe8f3493f3
187 N8788bc86fd254b6da09a44fe8f3493f3 rdf:first sg:person.01140572250.01
188 rdf:rest N7f662d0c54524d5bb6ecf2510d9a2f1d
189 N9ec56335872049e4ad2f94d1f4883890 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
190 schema:name Mitochondria
191 rdf:type schema:DefinedTerm
192 Na3a91ad825254966bd958e2e21ac40a7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
193 schema:name TNF-Related Apoptosis-Inducing Ligand
194 rdf:type schema:DefinedTerm
195 Na79c40450a4a4aeaa6a453543496b6cb schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
196 schema:name Proto-Oncogene Proteins
197 rdf:type schema:DefinedTerm
198 Nb28f67b73dd24351af877fe894160b8f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
199 schema:name Membrane Proteins
200 rdf:type schema:DefinedTerm
201 Nb4a2a60f243d4da18db71ddaae8ce1fd schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
202 schema:name Apoptosis
203 rdf:type schema:DefinedTerm
204 Nb57a4c5092c9448d997955e6e206b420 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
205 schema:name bcl-2-Associated X Protein
206 rdf:type schema:DefinedTerm
207 Nb62cdc9f409a410f956542dd5392ce43 schema:volumeNumber 11
208 rdf:type schema:PublicationVolume
209 Nc0047e821b28485d9ccd046df049b771 schema:name doi
210 schema:value 10.1007/s10495-006-0283-6
211 rdf:type schema:PropertyValue
212 Nc07dab4d19444a448e3f2960a56a7338 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
213 schema:name Apoptosis Regulatory Proteins
214 rdf:type schema:DefinedTerm
215 Nc21d5dfb40734f4d877d399670f8e235 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
216 schema:name Enzyme Inhibitors
217 rdf:type schema:DefinedTerm
218 Nc407837d70d745eb87910dbaf32b337d schema:issueNumber 12
219 rdf:type schema:PublicationIssue
220 Nddbf1c1eeaad411b9540ba83f9d7a274 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
221 schema:name Histone Deacetylases
222 rdf:type schema:DefinedTerm
223 Ne746461832d544e7bd3e9586aa16d6f0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
224 schema:name Myeloid Cell Leukemia Sequence 1 Protein
225 rdf:type schema:DefinedTerm
226 Nf9b98daa1ab8464f945808623fe10d35 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
227 schema:name Melanoma
228 rdf:type schema:DefinedTerm
229 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
230 schema:name Biological Sciences
231 rdf:type schema:DefinedTerm
232 anzsrc-for:0601 schema:inDefinedTermSet anzsrc-for:
233 schema:name Biochemistry and Cell Biology
234 rdf:type schema:DefinedTerm
235 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
236 schema:name Medical and Health Sciences
237 rdf:type schema:DefinedTerm
238 anzsrc-for:1112 schema:inDefinedTermSet anzsrc-for:
239 schema:name Oncology and Carcinogenesis
240 rdf:type schema:DefinedTerm
241 sg:journal.1117236 schema:issn 1360-8185
242 1573-675X
243 schema:name Apoptosis
244 schema:publisher Springer Nature
245 rdf:type schema:Periodical
246 sg:person.01073667716.42 schema:affiliation grid-institutes:None
247 schema:familyName Hersey
248 schema:givenName Peter
249 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01073667716.42
250 rdf:type schema:Person
251 sg:person.01140572250.01 schema:affiliation grid-institutes:None
252 schema:familyName Borrow
253 schema:givenName Jodie
254 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01140572250.01
255 rdf:type schema:Person
256 sg:person.01210116316.18 schema:affiliation grid-institutes:None
257 schema:familyName Zhang
258 schema:givenName Xu Dong
259 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01210116316.18
260 rdf:type schema:Person
261 sg:person.01311773466.89 schema:affiliation grid-institutes:None
262 schema:familyName Gillespie
263 schema:givenName Susan
264 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01311773466.89
265 rdf:type schema:Person
266 sg:pub.10.1038/20959 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031691936
267 https://doi.org/10.1038/20959
268 rdf:type schema:CreativeWork
269 sg:pub.10.1038/35101078 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021222128
270 https://doi.org/10.1038/35101078
271 rdf:type schema:CreativeWork
272 sg:pub.10.1038/38664 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026663914
273 https://doi.org/10.1038/38664
274 rdf:type schema:CreativeWork
275 sg:pub.10.1038/5517 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010598958
276 https://doi.org/10.1038/5517
277 rdf:type schema:CreativeWork
278 sg:pub.10.1038/ncb1026 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012014764
279 https://doi.org/10.1038/ncb1026
280 rdf:type schema:CreativeWork
281 sg:pub.10.1038/sj.cdd.4401507 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020681987
282 https://doi.org/10.1038/sj.cdd.4401507
283 rdf:type schema:CreativeWork
284 sg:pub.10.1038/sj.cdd.4401535 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015856802
285 https://doi.org/10.1038/sj.cdd.4401535
286 rdf:type schema:CreativeWork
287 sg:pub.10.1038/sj.onc.1207830 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049638392
288 https://doi.org/10.1038/sj.onc.1207830
289 rdf:type schema:CreativeWork
290 sg:pub.10.1038/sj.onc.1207970 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048306287
291 https://doi.org/10.1038/sj.onc.1207970
292 rdf:type schema:CreativeWork
293 sg:pub.10.1038/sj.onc.1208191 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030634267
294 https://doi.org/10.1038/sj.onc.1208191
295 rdf:type schema:CreativeWork
296 grid-institutes:None schema:alternateName Immunology and Oncology Unit, Room 443, Newcastle Misericordiae Hospital, NSW, Australia
297 Room 443, David Maddison Clinical Sciences Building, Cnr. King & Watt Streets, 2300, Newcastle, NSW, Australia
298 schema:name Immunology and Oncology Unit, Room 443, Newcastle Misericordiae Hospital, NSW, Australia
299 Room 443, David Maddison Clinical Sciences Building, Cnr. King & Watt Streets, 2300, Newcastle, NSW, Australia
300 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...