H2O2 at physiological concentrations modulates Leydig cell function inducing oxidative stress and apoptosis View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2006-01

AUTHORS

D. K Gautam, M. M. Misro, S. P. Chaki, N. Sehgal

ABSTRACT

H(2)O(2) is one of the active reactive oxygen species secreted by macrophages that are seen closely aligned with Leydig cells in the testicular interstitium. The present study was initiated to investigate the role of H(2)O(2) on Leydig cell function in vitro at physiological concentrations. Significant decrease in both testosterone production (p < 0.05) and 3 beta-hydroxysteroid dehydrogenase activity (p < 0.05) in adult Leydig cells were observed even with H(2)O(2) at low concentrations (30 - 50 microM). H(2)O(2) exposure increased oxidative stress in Leydig cells with the rise in lipid peroxidation and fall in the activities of the antioxidant enzymes; superoxide dismutase (SOD), catalase (CAT) & glutathione-s-transferase (GST). There was also a marginal increase (approximately 8%) in cell apoptosis accompanied by rise in FasL expression and caspase-3 activation. The above findings indicate that H(2)O(2) as a bio-molecule modulates Leydig cell function at or below physiological concentrations through a variety of actions like decrease in steroidogenic enzyme activity and increase in oxidative stress and apoptosis. More... »

PAGES

39-46

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s10495-005-3087-1

DOI

http://dx.doi.org/10.1007/s10495-005-3087-1

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1047486709

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/16374549


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curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s10495-005-3087-1'

RDF/XML is a standard XML format for linked data.

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