Fusarium proliferatum, an endophytic fungus from Dysoxylum binectariferum Hook.f, produces rohitukine, a chromane alkaloid possessing anti-cancer activity View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2011-09-04

AUTHORS

Patel Mohana Kumara, Sebastian Zuehlke, Vaidyanathan Priti, Bheemanahally Thimmappa Ramesha, Singh Shweta, Gudasalamani Ravikanth, Ramesh Vasudeva, Thankayyan Retnabai Santhoshkumar, Michael Spiteller, Ramanan Uma Shaanker

ABSTRACT

Rohitukine is a chromane alkaloid possessing anti-inflammatory, anti-cancer and immuno-modulatory properties. The compound was first reported from Amoora rohituka (Meliaceae) and later from Dysoxylum binectariferum (Meliaceae) and Schumanniophyton problematicum (Rubiaceae). Flavopiridol, a semi-synthetic derivative of rohitukine is a potent CDK inhibitor and is currently in Phase III clinical trials. In this study, the isolation of an endophytic fungus, Fusarium proliferatum (MTCC 9690) from the inner bark tissue of Dysoxylum binectariferum Hook.f (Meliaceae) is reported. The endophytic fungus produces rohitukine when cultured in shake flasks containing potato dextrose broth. The yield of rohitukine was 186 μg/100 g dry mycelial weight, substantially lower than that produced by the host tissue. The compound from the fungus was authenticated by comparing the LC–HRMS and LC–HRMS/MS spectra with those of the reference standard and that produced by the host plant. Methanolic extract of the fungus was cytotoxic against HCT-116 and MCF-7 human cancer cell lines (IC50 = 10 μg/ml for both cancer cell lines). More... »

PAGES

323-329

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s10482-011-9638-2

DOI

http://dx.doi.org/10.1007/s10482-011-9638-2

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1004672664

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/21898150


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